OMGAQ / Omega Therapeutics, Inc. - Pemfailan SEC, Laporan Tahunan, Penyata Proksi

Omega Therapeutics, Inc.
US ˙ OTCPK ˙ US68217N1054
SIMBOL INI TIDAK AKTIF LAGI

Statistik Asas
CIK 1850838
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Omega Therapeutics, Inc.
SEC Filings (Chronological Order)
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March 31, 2025 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-40657 Omega Therapeutics, Inc. (Exact name of registrant as specified in

March 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 21, 2025

As filed with the Securities and Exchange Commission on March 21, 2025 Registration No.

March 21, 2025 POS AM

As filed with the Securities and Exchange Commission on March 21, 2025

As filed with the Securities and Exchange Commission on March 21, 2025 Registration No.

March 20, 2025 25

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D. C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-40657 OMEGA THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D. C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-40657 OMEGA THERAPEUTICS, INC. THE NASDAQ GLOBAL SELECT MARKET (Exact name of Issuer as specified in its charter, and name of Exchange where security is listed and/or register

February 24, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 18, 2025 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commiss

February 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 10, 2025 Omega Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 10, 2025 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commiss

February 3, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 29, 2025 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commissi

January 28, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 22, 2025 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commissi

January 17, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 13, 2025 Omega Therapeuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 13, 2025 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commissi

January 10, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 10, 2025 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commissi

December 31, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 29, 2024 Omega Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 29, 2024 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commiss

December 6, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 3, 2024 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commissi

November 14, 2024 EX-10.5

Separation Agreement and Release, by and between Omega Therapeutics, Inc. and Mahesh Karande, effective November 26, 2024.

Exhibit 10.5 Separation Agreement and Release This Separation Agreement and Release (“Agreement”) is made by and between Mahesh Karande (“Executive”) and Omega Therapeutics, Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). Capitalized terms used but not defined in this Agreement shall have the meanings set forth in the Employment Agreement

November 14, 2024 EX-10.1

Amended and Restated Shared Space Arrangement by and between Omega Therapeutics, Inc. and Apriori Bio, Inc., effective November 18, 2024.

Exhibit 10.1 AMENDED AND RESTATED SHARED SPACE ARRANGEMENT This Amended and Restated Shared Space Arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 18th day of November, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 0

November 14, 2024 EX-10.2

Amended and Restated Shared Space Arrangement by and between Omega Therapeutics, Inc. and Prologue Medicines, Inc. (formerly Flagship Labs 89, Inc.), effective November 18, 2024.

Exhibit 10.2 AMENDED AND RESTATED SHARED SPACE ARRANGEMENT This Amended and Restated Shared Space Arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 18th day of November, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 0

November 14, 2024 EX-10.3

Shared Space Arrangement by and between Omega Therapeutics, Inc. and Flagship Labs 107, Inc., effective November 18, 2024.

Exhibit 10.3 SHARED SPACE ARRANGEMENT This shared space arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 18th day of November, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 02141, and Flagship Labs 107, Inc., a Delaw

November 14, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 14, 2024 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commiss

November 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

November 14, 2024 EX-10.4

Amended and Restated Employment Agreement, by and between Omega Therapeutics, Inc. and Kaan Certel, Ph.D., effective November 14, 2024.

Exhibit 10.4 Amended and Restated Employment Agreement This Amended and Restated Employment Agreement (this “Agreement”) is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the “Company”), and Kaan Certel (“Executive”) (collectively referred to herein as the “Parties” or individually referred to as a “Party”) effective as of November 14, 20

November 14, 2024 EX-99.1

OMEGA THERAPEUTICS Harnessing the Power of Epigenomic Controllers Pioneering a New Class of Programmable Epigenomic Medicines November 2024

Exhibit 99.1 OMEGA THERAPEUTICS Harnessing the Power of Epigenomic Controllers Pioneering a New Class of Programmable Epigenomic Medicines November 2024 Disclaimer and Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this presentation that do not relate to matters

October 4, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 2, 2024 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commissio

August 30, 2024 EX-10.4

Shared Space Arrangement by and between Omega Therapeutics, Inc. and Flagship Labs 101, Inc., effective September 1, 2024

Exhibit 10.4 SHARED SPACE ARRANGEMENT This shared space arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of September, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 02141, and Flagship Labs 101, Inc., a Delaw

August 30, 2024 EX-10.2

Amended and Restated Shared Space Arrangement by and between Omega Therapeutics, Inc. and Metaphore Biotechnologies, Inc., effective September 1, 2024

Exhibit 10.2 AMENDED AND RESTATED SHARED SPACE ARRANGEMENT This Amended and Restated Shared Space Arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of September, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 0

August 30, 2024 EX-10.5

Shared Space Arrangement by and between Omega Therapeutics, Inc. and Flagship Labs 104, Inc., effective September 1, 2024

Exhibit 10.5 SHARED SPACE ARRANGEMENT This shared space arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of September, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 02141, and Flagship Labs 104, Inc., a Delaw

August 30, 2024 EX-10.3

Amended and Restated Shared Space Arrangement by and between Omega Therapeutics, Inc. and Prologue Medicines, Inc. (formerly Flagship Labs 89, Inc.), effective September 1, 2024

Exhibit 10.3 AMENDED AND RESTATED SHARED SPACE ARRANGEMENT This Amended and Restated Shared Space Arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of September, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 0

August 30, 2024 EX-10.1

Amended and Restated Shared Space Arrangement by and between Omega Therapeutics, Inc. and Apriori Bio, Inc., effective September 1, 2024

Exhibit 10.1 AMENDED AND RESTATED SHARED SPACE ARRANGEMENT This Amended and Restated Shared Space Arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of September, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 0

August 30, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 27, 2024 Omega Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 27, 2024 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commissio

August 6, 2024 EX-10.5

Amendment, dated June 17, 2024 to Shared Space Agreement, dated July 12, 2023, by and between Omega Therapeutics, Inc. and Metaphore Biotechnologies, Inc.

Exhibit 10.5 AMENDMENT #1 TO SHARED SPACE ARRANGEMENT This Amendment #1 To Shared Space Arrangement (this “Amendment”) is made effective as of July 1, 2024, by and between OMEGA THERAPEUTICS, INC., a Delaware corporation (“Licensor” or “Tenant”), having an address of 140 First Street, Ste 501, Cambridge, MA 02141, and Metaphore Biotechnologies, Inc., (“Licensee” or “Space Occupant”), having an add

August 6, 2024 EX-10.2

Separation Agreement, by and between Omega Therapeutics, Inc. and Yan Moore, M.D., dated June 5, 2024.

Exhibit 10.2 Separation Agreement and Release This Separation Agreement and Release (“Agreement”) is made by and between Yan Moore (“Executive”) and Omega Therapeutics, Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). Capitalized terms used but not defined in this Agreement shall have the meanings set forth in the Employment Agreement (as d

August 6, 2024 EX-10.9

Second Amendment to Lease Agreement, dated June 24, 2024 between Omega Therapeutics, Inc. and ARE-MA Region No. 94, LLC

Exhibit 10.9 SECOND AMENDMENT TO LEASE THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is dated as of June 24, 2024 (the “Second Amendment Effective Date”), by and between ARE-MA REGION NO. 94, LLC, a Delaware limited liability company (“Landlord”), and OMEGA THERAPEUTICS, INC., a Delaware corporation (“Tenant”). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement

August 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

August 6, 2024 EX-10.1

Non-Employee Director Compensation Program, effective May 28, 2024.

Exhibit 10.1 Omega Therapeutics, Inc. Non-Employee Director Compensation Program (effective May 28, 2024) Non-employee members of the board of directors (the “Board”) of Omega Therapeutics, Inc. (the “Company”) shall receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”). The cash and equity compensation described in this Program shall

August 6, 2024 EX-10.6

Amendment, dated June 17, 2024 to Shared Space Agreement, dated July 11, 2023, by and between Omega Therapeutics, Inc. and Apriori Bio, Inc.

Exhibit 10.6 AMENDMENT #1 TO SHARED SPACE ARRANGEMENT This Amendment #1 To Shared Space Arrangement (this “Amendment”) is made effective as of July 1, 2024, by and between OMEGA THERAPEUTICS, INC., a Delaware corporation (“Licensor” or “Tenant”), having an address of 140 First Street, Ste 501, Cambridge, MA 02141, and Apriori Bio, Inc., (“Licensee” or “Space Occupant”), having an address of 140 Fi

August 6, 2024 EX-10.3

Separation Agreement, by and between Omega Therapeutics, Inc. and Joshua Reed, dated June 3, 2024.

Exhibit 10.3 Separation Agreement and Release This Separation Agreement and Release (“Agreement”) is made by and between Joshua Reed (“Executive”) and Omega Therapeutics, Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). Capitalized terms used but not defined in this Agreement shall have the meanings set forth in the Employment Agreement (as

August 6, 2024 EX-10.10

Third Amendment to Lease Agreement, dated July 31, 2024 between Omega Therapeutics, Inc. and ARE-MA Region No. 94, LLC

Exhibit 10.10 THIRD AMENDMENT TO LEASE THIS THIRD AMENDMENT TO LEASE (this “Third Amendment”) is dated as of July 31, 2024 (the “Third Amendment Effective Date”), by and between ARE-MA REGION NO. 94, LLC, a Delaware limited liability company (“Landlord”), and OMEGA THERAPEUTICS, INC., a Delaware corporation (“Tenant”). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement dat

August 6, 2024 EX-99.1

Omega Therapeutics Reports Second Quarter 2024 Financial Results and Highlights Recent Company Progress

Omega Therapeutics Reports Second Quarter 2024 Financial Results and Highlights Recent Company Progress • Advanced MYCHELANGELO™ I trial; Company expects to select recommended dose for expansion and initiate monotherapy and combination expansion cohorts in fourth quarter of 2024 • Reinforced diverse capabilities of the OMEGA platform at scientific meetings, including demonstration of precise and durable upregulation of gene expression • Strengthened leadership team with appointment of Kaan Certel, Ph.

August 6, 2024 EX-10.8

Shared Space Agreement, dated August 1, 2024 by and between Omega Therapeutics, Inc. and Flagship Labs 97, Inc.

Exhibit 10.8 SHARED SPACE ARRANGEMENT This shared space arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of August, 2024 (the “Effective Date”) by and between Omega Therapeutics, Inc., a Delaware corporation (“Licensor” or “Tenant”) with an address of 140 First Street, Ste 501, Cambridge, Massachusetts 02141, and Flagship Labs 97, Inc., a Delaware

August 6, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2024 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission

August 6, 2024 EX-10.4

Amended and Restated Employment Agreement, by and between Omega Therapeutics, Inc. and Barbara Chan, dated May 28, 2024

Exhibit 10.4 Amended and Restated Employment Agreement This Amended and Restated Employment Agreement (this “Agreement”), is entered into on May 28, 2024, by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the “Company”), and Barbara Chan (“Executive”) (collectively referred to herein as the “Parties” or individually referred to as a “Party”) and

August 6, 2024 EX-10.7

Amendment, dated June 17, 2024 to Shared Space Agreement, dated July 12, 2023, by and between Omega Therapeutics, Inc. and Flagship Labs 89, Inc. (now known as Prologue Medicines, Inc.

Exhibit 10.7 AMENDMENT #1 TO SHARED SPACE ARRANGEMENT This Amendment #1 To Shared Space Arrangement (this “Amendment”) is made effective as of July 1, 2024, by and between OMEGA THERAPEUTICS, INC., a Delaware corporation (“Licensor” or “Tenant”), having an address of 140 First Street, Ste 501, Cambridge, MA 02141, and Prologue Medicines, Inc. (formerly Flagship Labs 89, Inc.), (“Licensee” or “Spac

June 24, 2024 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 20, 2024 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commission

June 24, 2024 EX-3.1

Restated Certificate of Incorporation of Omega Therapeutics, Inc., dated August 3, 2021 and the Certificate of Amendment to the Restated Certificate of Incorporation of Omega Therapeutics, Inc., dated June 20, 2024.

Exhibit 3.1 RESTATED CERTIFICATE OF INCORPORATION OF OMEGA THERAPEUTICS, INC. The name of the corporation is Omega Therapeutics, Inc. The corporation was originally incorporated by the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware on July 13, 2016 under the name VL42, Inc. This Restated Certificate of Incorporation of the corporation, whic

May 30, 2024 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 28, 2024 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commission F

May 30, 2024 8-K/A

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A Amendment No. 1 CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 10, 2024 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorpor

May 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

May 6, 2024 EX-99.1

Omega Therapeutics Reports First Quarter 2024 Financial Results and Highlights Recent Company Progress

Omega Therapeutics Reports First Quarter 2024 Financial Results and Highlights Recent Company Progress • Advanced MYCHELANGELO™ I trial dose escalation to Cohort 5; Presentation of additional monotherapy data and planned expansion into Phase 2 settings expected in mid-2024 • Presented new preclinical data demonstrating potential of a MYC-targeting epigenomic controller in NSCLC at AACR 2024 • Company to present new preclinical data demonstrating durable epigenomic upregulation and other OMEGA platform capabilities at ASGCT 2024 CAMBRIDGE, Mass.

May 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2024 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 6, 2024 EX-10.1

Omega Therapeutics, Inc. 2021 Incentive Award Plan Stock Option Grant Notice and Stock Option Agreement issued to Mahesh Karande on February 7, 2024

Exhibit 10.1 OMEGA THERAPEUTICS, INC. 2021 INCENTIVE AWARD PLAN STOCK OPTION GRANT NOTICE Capitalized terms not specifically defined in this Stock Option Grant Notice (the “Grant Notice”) have the meanings given to them in the 2021 Incentive Award Plan (as amended from time to time, the “Plan”) of Omega Therapeutics, Inc. (the “Company”). The Company has granted to the participant listed below (“P

April 29, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 29, 2024 DEFA14A

COURTESY COPY OF FINAL_2024_DEFA14A

April 29, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 19, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 16, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 10, 2024 Omega Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 10, 2024 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commission

March 28, 2024 EX-10.9

Employment Agreement by and between Joshua Reed and the Registrant, dated April 28, 2022.

Exhibit 10.9 Employment Agreement This Employment Agreement (this “Agreement”), dated as of April 28, 2022, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the “Company”), and Joshua Reed (“Executive”) (collectively referred to herein as the “Parties” or individually referred to as a “Party”). This Agreement shall be effective as of the

March 28, 2024 EX-10.33

Research Collaboration Agreement with Novo Nordisk A/S, Pioneering Medicines 08, Inc., Omega Therapeutics, Inc. and the other parties thereto, dated as of December 31, 2023

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY “[***]”, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL.

March 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 28, 2024 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission

March 28, 2024 EX-10.20

Waiver, Confirmation and Agreement Regarding Research Collaboration effective December 31, 2023, between Whitehead Institute for Biomedical Research and the Registrant, relating to Exclusive License Agreement, dated May 22, 2019.

Exhibit 10.20 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY “[***]”, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. Confidential Effective December 31, 2023 Omega Therapeutics, Inc. 140 First Street, Suite 501 Cambridge, Massachusetts 02141 Re: Waiver, Confirmation and Agreement Regarding Res

March 28, 2024 EX-97

Policy Relating to Recovery of Erroneously Awarded Compensation

Exhibit 97 OMEGA THERAPEUTICS, INC. POLICY FOR RECOVERY OF ERRONEOUSLY AWARDED COMPENSATION Omega Therapeutics, Inc. (the “Company”) has adopted this Policy for Recovery of Erroneously Awarded Compensation (the “Policy”), effective as of October 2, 2023 (the “Effective Date”). Capitalized terms used in this Policy but not otherwise defined herein are defined in Section 11. 1. Persons Subject to Po

March 28, 2024 EX-10.12

Amendment to Consulting Agreement by and between Richard A. Young and the Registrant, dated October 5, 2022.

Exhibit 10.12 October 5, 2022 Richard A. Young, Ph.D. 1 Longfellow Place, Apt. 3510 Boston, MA 02114 Re: Amendment #3 to Consulting Agreement Dear Richard: This is in reference to the Consulting Agreement between VL42, d/b/a Omega Therapeutics, Inc., and Richard A. Young, Ph.D. dated November 7, 2016 (the “Agreement”). All capitalized terms used in this letter and not otherwise defined in this let

March 28, 2024 EX-10.22

Waiver, Confirmation and Agreement Regarding Research Collaboration effective December 31, 2023, between Whitehead Institute for Biomedical Research and the Registrant, relating to Co-Exclusive License Agreement, dated May 22, 2019.

Exhibit 10.22 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY “[***]”, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. Confidential Effective December 31, 2023 Omega Therapeutics, Inc. 140 First Street, Suite 501 Cambridge, Massachusetts 02141 Re: Waiver, Confirmation and Agreement Regarding Res

March 28, 2024 EX-10.18

Letter Agreement re License Agreement between Flagship Pioneering Innovations V, Inc. and the Registrant dated December 31, 2023 relating to the License Agreement dated March 12, 2019

Exhibit 10.18 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY “[***]”, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. Executed Version Confidential OMEGA THERAPEUTICS, INC. 140 First Street, Suite 501 Cambridge, MA 02141 December 31, 2023 Flagship Pioneering Innovations V, Inc. c/o Flagship Pio

March 28, 2024 EX-10.13

Amendment to Consulting Agreement by and between Richard A. Young and the Registrant, dated October 6, 2023.

Exhibit 10.13 October 6, 2023 Richard A. Young, Ph.D. 1 Longfellow Place, Apt. 3510 Boston, MA 02114 Re: Omega / Young - Amendment #4 to Consulting Agreement Dear Richard: This is in reference to the Consulting Agreement between VL42, d/b/a Omega Therapeutics, Inc., and Richard A. Young, Ph.D. dated November 7, 2016 (the “Agreement”). All capitalized terms used in this letter and not otherwise def

March 28, 2024 EX-99.1

Omega Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Strategic Update

Omega Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Strategic Update • Advanced OTX-2002 in MYCHELANGELO™ I trial; initial cohorts demonstrated encouraging disease control rate in late-stage HCC patients • Established a research collaboration with Novo Nordisk to develop an epigenomic controller for obesity, expanding the pipeline into the cardiometabolic space • Announced strategic prioritization to focus resources on potential near-term value drivers, support long-term growth, and extend cash runway into Q1 2025 CAMBRIDGE, Mass.

March 28, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40657 Omega Therapeut

February 9, 2024 SC 13G/A

OMGA / Omega Therapeutics, Inc. / HarbourVest Partners L.P. - SC 13G/A Passive Investment

SC 13G/A 1 d764529dsc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Omega Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 68217N105 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Ch

February 9, 2024 EX-99.1

AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G

EX-99.1 2 d764529dex991.htm EX-99.1 Exhibit 1 AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G Pursuant to Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned agree that the Statement on Schedule 13G to which this Exhibit is attached is filed on behalf of each of them. Each of them is individually eligible to use the Schedule 13G to which this Ex

January 5, 2024 EX-99.1

Omega Therapeutics Announces Research Collaboration with Novo Nordisk to Develop a Novel Therapeutic for Obesity Management - Collaboration will leverage Omega’s proprietary platform to develop an epigenomic controller designed to increase metabolic

Omega Therapeutics Announces Research Collaboration with Novo Nordisk to Develop a Novel Therapeutic for Obesity Management - Collaboration will leverage Omega’s proprietary platform to develop an epigenomic controller designed to increase metabolic activity and support obesity management – CAMBRIDGE, Mass.

January 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 31, 2023 Omega Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 31, 2023 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commiss

January 5, 2024 EX-99.2

Corporate Presentation by Omega Therapeutics, Inc., dated January 2024

December 11, 2023 EX-3.1

Amended and Restated Bylaws of Omega Therapeutics, Inc.

AMENDED AND RESTATED BYLAWS OF OMEGA THERAPEUTICS, INC. (a Delaware corporation) TABLE OF CONTENTS Page Article I CORPORATE OFFICES 1 1.1 Registered office 1 1.2 Other offices 1 Article II MEETINGS OF STOCKHOLDERS 1 2.1 Place of meetings 1 2.2 Annual meeting 1 2.3 Special meeting 1 2.4 Advance Notice Procedures for Business Brought Before a Meeting 2 2.5 Advance Notice Procedures for Nominations o

December 11, 2023 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 11, 2023 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commiss

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

November 9, 2023 EX-99.1

Omega Therapeutics Reports Third Quarter 2023 Financial Results and Highlights Recent Company Progress

Omega Therapeutics Reports Third Quarter 2023 Financial Results and Highlights Recent Company Progress • Announced promising preliminary clinical data for OTX-2002 from ongoing MYCHELANGELO™ I trial; clinical proof-of-platform established with potential applicability across a broad range of diseases • Advanced OMEGA platform capabilities and presented new preclinical data on multiple epigenomic controller programs at medical meetings • Further strengthened Board of Directors with appointment of Chris Schade as Chairman and addition of Michelle C.

November 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2023 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commissi

September 26, 2023 EX-99.1

September 26, 2023 MYCHELANGELO™ I: Preliminary Phase 1 Clinical Update

September 26, 2023 MYCHELANGELO™ I: Preliminary Phase 1 Clinical Update Disclaimer and Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.

September 26, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 26, 2023 Omega Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 26, 2023 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commis

September 22, 2023 EX-10.1

Fifth Amendment to Loan and Security Agreement, dated September 22, 2023

FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT This Fifth Amendment to Loan and Security Agreement (this “Amendment”) is entered into as of September 22, 2023, by and between PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), and OMEGA THERAPEUTICS, INC.

September 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 22, 2023 Omega Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 22, 2023 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commis

August 29, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 26, 2023 Omega Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 26, 2023 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation or organiza

August 3, 2023 EX-99.1

Omega Therapeutics Reports Second Quarter 2023 Financial Results and Highlights Recent Company Progress

EX-99.1 Exhibit 99.1 Omega Therapeutics Reports Second Quarter 2023 Financial Results and Highlights Recent Company Progress • Continued Enrollment in Monotherapy Dose Escalation Stage of Phase 1/2 MYCHELANGELO™ I Study; Preliminary First-in-Human Safety, Tolerability, Pharmacologic and Translational Data Anticipated in the Fourth Quarter of 2023 • Presented New Preclinical Data at the American So

August 3, 2023 424B5

Up to $60,000,000 Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-268254 PROSPECTUS SUPPLEMENT (To Prospectus dated November 18, 2022) Up to $60,000,000 Common Stock We have entered into an Open Market Sale AgreementSM, or the sales agreement, with Jefferies LLC, or Jefferies, relating to shares of our common stock, par value $0.001 per share, offered by this prospectus supplement and the ac

August 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 3, 2023 Omega Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 3, 2023 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation or organizat

August 3, 2023 EX-10.1

First Amendment to Lease between Omega Therapeutics, Inc. and ARE-MA Region No. 94, LLC, dated May 3, 2023

DocuSign Envelope ID: 5D3CE323-414A-498D-A95E-B45802F2F177 Exhibit 10.1 FIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is dated as of May 3 , 2023 (the “Effective Date”), by and between ARE-MA REGION NO. 94, LLC, a Delaware limited liability company (“Landlord”), and OMEGA THERAPEUTICS, INC., a Delaware corporation (“Tenant”). RECITALS A. Landlord and Tenant are pa

August 3, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

August 3, 2023 EX-10.1

Open Market Sale Agreement dated as of August 3, 2023 between Omega Therapeutics, Inc. and Jefferies LLC

EX-10.1 Exhibit 10.1 OPEN MARKET SALE AGREEMENTSM August 3, 2023 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Omega Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’

July 13, 2023 EX-10.1

Shared Space Agreement, dated as of July 12, 2023, by and between Omega Therapeutics, Inc. and Metaphor Biotechnologies, Inc.

SHARED SPACE ARRANGEMENT This shared space arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of August, 2023 (the “Effective Date”) by and between Omega Therapeutics, Inc.

July 13, 2023 EX-10.2

Shared Space Agreement, dated as of July 11, 2023, by and between Omega Therapeutics, Inc. and Apriori Bio, Inc.

SHARED SPACE ARRANGEMENT This shared space arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of September, 2023 (the “Effective Date”) by and between Omega Therapeutics, Inc.

July 13, 2023 EX-10.3

Shared Space Agreement, dated as of July 12, 2023, by and between Omega Therapeutics, Inc. and Flagship Labs 89, Inc.

SHARED SPACE ARRANGEMENT This shared space arrangement (this “Shared Space Arrangement”) is made and entered into effective as of the 1st day of August, 2023 (the “Effective Date”) by and between Omega Therapeutics, Inc.

July 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 11, 2023 Omega Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 11, 2023 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commission

July 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 10, 2023 Omega Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 10, 2023 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation or organizati

June 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2023 OMEGA THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2023 OMEGA THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission F

May 4, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

May 4, 2023 EX-99

Omega Therapeutics Reports First Quarter 2023 Financial Results and Highlights Recent Company Progress

EX-99 2 omga-ex991.htm EX-99.1 Omega Therapeutics Reports First Quarter 2023 Financial Results and Highlights Recent Company Progress • Continued to Advance Monotherapy Dose Escalation Stage of Ongoing Phase 1/2 MYCHELANGELO™ I Study; Preliminary Data Anticipated in 2023 • Announced Clinical Supply Agreement with Roche to Evaluate OTX-2002 in Combination with Atezolizumab in MYCHELANGELO I Study •

May 4, 2023 EX-10

Securities Purchase Agreement between Omega Therapeutics, Inc. and the purchasers identified therein, dated February 22, 2023

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of February 22, 2023, between Omega Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condit

May 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2023 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission Fi

April 25, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 25, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 25, 2023 DEFA14A

COURTESY COPY OF 2022_PROXY_NOTICE_-_DEFA

March 24, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1 (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-406

March 1, 2023 EX-99

Omega Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Corporate Update

Omega Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Corporate Update • Advanced Company’s Lead Program, OTX-2002, in the Clinic; Preliminary Data from Phase 1/2 MYCHELANGELO™ I Trial Anticipated in 2023 • Progressed IND-enabling Studies for OTX-2101; Company’s Development Candidate for MYC-driven Non-Small Cell Lung Cancer to Utilize a Novel Lung-Targeting Lipid Nanoparticle • Ended the Year with Cash, Cash Equivalents and Marketable Securities of $124.

March 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 1, 2023 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission

March 1, 2023 EX-10

Collaboration and License Agreement between Nitto Denko Corporation and the Registrant, dated October 12, 2022.

Certain information marked as [***] has been excluded from this exhibit because it is both (i) not material and (ii) the type that the Registrant treats as private or confidential.

March 1, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40657 Omega Therapeut

February 27, 2023 SC 13D/A

OMGA / Omega Therapeutics Inc / Flagship Ventures Fund V, L.P. - SC 13D/A Activist Investment

SC 13D/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* OMEGA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 68217N 105 (CUSIP Number) Noubar B. Afeyan, Ph.D. Flagship Pioneering 55 Cambridge Parkway, Suite 800E Cambridge, MA 02142 (617) 868-1888 (Name,

February 27, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 d459978dex991.htm EX-99.1 Exhibit 99.1 JOINT FILING AGREEMENT The persons below hereby agree that the Schedule 13D to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13D, shall be filed jointly on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 19

February 23, 2023 EX-10.1

Form of Securities Purchase Agreement.

EX-10.1 Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of February 22, 2023, between Omega Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms an

February 23, 2023 424B5

6,920,415 Shares Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-268254 PROSPECTUS SUPPLEMENT 6,920,415 Shares Common Stock We are offering 6,920,415 shares of our common stock in a registered direct offering directly to investors, or the Investors, pursuant to this prospectus supplement and the accompanying prospectus and securities purchase agreement with the Investors. This offerin

February 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 22, 2023 Omega Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 22, 2023 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation or organi

November 16, 2022 CORRESP

November 16, 2022

November 16, 2022 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

November 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

November 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2022 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commissi

November 8, 2022 EX-99.1

Omega Therapeutics Reports Third Quarter 2022 Financial Results and Recent Corporate Highlights

Omega Therapeutics Reports Third Quarter 2022 Financial Results and Recent Corporate Highlights ? First Patient Dosed in Phase 1/2 MYCHELANGELOTM I Trial of OTX-2002 ? OTX-2002 Granted Orphan Drug Designation by U.

November 8, 2022 S-3

As filed with the Securities and Exchange Commission on November 8, 2022

Table of Contents As filed with the Securities and Exchange Commission on November 8, 2022 Registration No.

November 8, 2022 EX-4.3

Form of Indenture.

Exhibit 4.3 OMEGA THERAPEUTICS, INC. INDENTURE Dated as of , 20 [] Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 4 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 5 Section 2.1. Issuable in Series 5 Section 2.2. Establis

November 8, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Omega Therapeutics, Inc.

October 12, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2022 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commissi

September 1, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 31, 2022 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation or organiza

August 4, 2022 EX-99.1

Omega Therapeutics Reports Second Quarter 2022 Financial Results and Highlights Recent Company Progress

EX-99.1 2 omga-ex991.htm EX-99.1 Exhibit 99.1 Omega Therapeutics Reports Second Quarter 2022 Financial Results and Highlights Recent Company Progress • FDA Clearance of IND Application for OTX-2002, the First Ever Epigenomic Controller, for MYC Driven Hepatocellular Carcinoma Received • Launch of Phase 1/2 Clinical Trial Under the MYCHELANGELOTM Clinical Program in Patients Expected in 2H’22 • Dat

August 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

August 4, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 04, 2022 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commissio

June 9, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2022 OMEGA THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission F

May 4, 2022 EX-10.4

Employment Agreement by and between Joshua Reed and the Registrant, dated April 28, 2022.

Exhibit 10.4 Employment Agreement This Employment Agreement (this ?Agreement?), dated as of [ ], 2022, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the ?Company?), and Joshua Reed (?Executive?) (collectively referred to herein as the ?Parties? or individually referred to as a ?Party?). This Agreement shall be effective as of the date

May 4, 2022 EX-10.2

Employment Agreement by and between Kevin McManus and the Registrant, dated February 3, 2022.

Exhibit 10.2 Employment Agreement This Employment Agreement (this ?Agreement?), dated as of February 03, 2022, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the ?Company?), and Kevin McManus (?Executive?) (collectively referred to herein as the ?Parties? or individually referred to as a ?Party?). This Agreement shall be effective as o

May 4, 2022 EX-10.3

Employment Agreement by and between Ling Zeng and the Registrant, dated March 18, 2022.

Exhibit 10.3 Employment Agreement This Employment Agreement (this ?Agreement?), dated as of March 18, 2022, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the ?Company?), and Ling Zeng (?Executive?) (collectively referred to herein as the ?Parties? or individually referred to as a ?Party?). This Agreement shall be effective as of the d

May 4, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 04, 2022 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission F

May 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

May 4, 2022 EX-99.1

Omega Therapeutics Reports First Quarter 2022 Financial Results and Highlights Recent Company Progress • Investigational New Drug Application for OTX-2002 for MYC Driven Hepatocellular Carcinoma on Track to be Submitted in the First Half of 2022 • Ad

Exhibit 99.1 Omega Therapeutics Reports First Quarter 2022 Financial Results and Highlights Recent Company Progress ? Investigational New Drug Application for OTX-2002 for MYC Driven Hepatocellular Carcinoma on Track to be Submitted in the First Half of 2022 ? Additional Omega Epigenomic Controller? Development Candidates on Track to be Nominated in the Middle of 2022 ? $200.8 Million in Cash, Cas

April 29, 2022 DEFA14A

COURTESY COPY OF PROXY_NOTICE_SIGN-OFF_-_

April 29, 2022 DEF 14A

Definitive Proxy Statement on Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 29, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amend

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 28, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2022 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission

March 10, 2022 EX-10.14

Amendment to Shared Space Agreement between Omega Therapeutics, Inc. and Senda Biosciences, Inc., dated January 31, 2022.

Exhibit 10.14 AMENDMENT NO. 1 TO THE SHARED SPACE ARRANGEMENT This AMENDMENT NO. 1 TO THE SHARED SPACE ARRANGEMENT (the ?Amendment?), is made effective as of January 31, 2022 (the ?Effective Date?) by and between SENDA BIOSCIENCES, Inc., (formerly Kintai Therapeutics, Inc.) a Delaware corporation (?Licensor?), and OMEGA THERAPEUTICS, INC., a Delaware corporation (?Licensee?). All capitalized terms

March 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2022 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commission

March 10, 2022 EX-10.13

Lease Agreement between Omega Therapeutics, Inc. and ARE-MA Region No, 94, LLC.

EX-10.13 6 omga-ex1013.htm EX-10.13 DocuSign Envelope ID: 95812A0E-597B-4C31-9F12-CB594CA06309 Exhibit 10.13 LEASE AGREEMENT THIS LEASE AGREEMENT (this “Lease”) is made this 4 day of November, 2021, between ARE-MA REGION NO. 94, LLC, a Delaware limited liability company (“Landlord”), and OMEGA THERAPEUTICS, INC., a Delaware corporation (“Tenant”). Premises: That portion of the Building containing

March 10, 2022 EX-10.9

Consulting Agreement by and between Richard A. Young and the Registrant, dated November 7, 2016.

Exhibit 10.9 CONSULTING AGREEMENT THIS CONSULTING AGREEMENT (the ?Agreement?), made this 7th day of November, 2016 (the ?Effective Date?) is entered into by VL42, Inc., a Delaware corporation with offices at 55 Cambridge Parkway, 8th Floor, Cambridge, MA 02142 (the ?Company?), and Richard A. Young, Ph.D., (the ?Consultant?) (each herein referred to individually as a ?Party,? or collectively as the

March 10, 2022 EX-10.8

Employment Agreement by and between Yan Moore and the Registrant, dated December 12, 2021.

Exhibit 10.8 Employment Agreement This Employment Agreement (this ?Agreement?), dated as of December 12, 2021, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the ?Company?), and Yan Moore (?Executive?) (collectively referred to herein as the ?Parties? or individually referred to as a ?Party?). This Agreement shall be effective as of th

March 10, 2022 EX-10.10

Amendment to Consulting Agreement by and between Richard A. Young and the Registrant, dated October 29, 2021.

Exhibit 10.10 October 29, 2021 Richard A. Young, Ph.D. [XXX] [XXX] Re: Amendment to Consulting Agreement Dear Richard: This is in reference to the Consulting Agreement between VL42, d/b/a Omega Therapeutics, Inc., and Richard A. Young, Ph.D. dated November 7, 2016 (the ?Agreement?). All capitalized terms used in this letter and not otherwise defined in this letter shall have the same meaning as in

March 10, 2022 EX-21.1

Subsidiaries of the Registrant.

Exhibit 21.1 Subsidiaries of the Registrant Entity Name Jurisdiction of Incorporation Omega Therapeutics Security Corporation Massachusetts

March 10, 2022 EX-4.4

Description of Capital Stock.

EX-4.4 2 omga-ex44.htm EX-4.4 Exhibit 4.4 DESCRIPTION OF CAPITAL STOCK As of December 31, 2021, Omega Therapeutics, Inc. had one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). References herein to “we,” “us,” “our” and the “Company” refer to Omega Therapeutics, Inc. and not to any of its subsidiaries. Capital Structure The f

March 10, 2022 EX-99.1

Omega Therapeutics Reports Fourth Quarter and Full Year 2021 Financial Results and Outlines Key Corporate Objectives for 2022

Exhibit 99.1 Omega Therapeutics Reports Fourth Quarter and Full Year 2021 Financial Results and Outlines Key Corporate Objectives for 2022 ? Investigational New Drug Application for OTX-2002 for c-Myc Driven Hepatocellular Carcinoma On Track to be Submitted in the First Half of 2022 ? Additional Omega Epigenomic Controller? Development Candidates Targeted to be Announced in the First Half of 2022

March 10, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40657 Omega Therapeut

February 14, 2022 EX-99.1

AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G

Exhibit 1 AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G Pursuant to Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned agree that the Statement on Schedule 13G to which this Exhibit is attached is filed on behalf of each of them.

February 14, 2022 SC 13G

OMGA / Omega Therapeutics, Inc. / HarbourVest Partners L.P. - SC 13G Passive Investment

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Omega Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 68217N105 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to design

December 21, 2021 EX-10.1

Fourth Amendment to Loan and Security Agreement, dated December 20, 2021.

Exhibit 10.1 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT This Fourth Amendment to Loan and Security Agreement (this ?Amendment?) is entered into as of December 20, 2021, by and between PACIFIC WESTERN BANK, a California state chartered bank (?Bank?), and OMEGA THERAPEUTICS, INC. (?Borrower?), RECITALS Borrower and Bank are parties to that certain Loan and Security Agreement dated as of March 9

December 21, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 20, 2021 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commiss

November 10, 2021 EX-99.1

Omega Therapeutics Reports Third Quarter 2021 Financial Results and Outlines Key Corporate Objectives

Exhibit 99.1 Omega Therapeutics Reports Third Quarter 2021 Financial Results and Outlines Key Corporate Objectives ? OTX-2002, the Company?s Lead Program Targeting c-MYC for the Treatment of Hepatocellular Carcinoma, is Currently Advancing Through IND-Enabling Studies; Good Progress Across Broad Pipeline ? Established Strategic Collaboration with Stanford University School of Medicine for Potentia

November 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

November 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2021 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commiss

November 8, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 04, 2021 Omega Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40657 81-3247585 (State or Other Jurisdiction of Incorporation) (Commiss

September 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40657 Omega Therapeutics, Inc.

September 10, 2021 EX-99.1

Omega Therapeutics Reports Second Quarter 2021 Financial Results and Outlines Key Corporate Objectives

EX-99.1 2 omga-ex9916.htm EX-99.1 Exhibit 99.1 Omega Therapeutics Reports Second Quarter 2021 Financial Results and Outlines Key Corporate Objectives • Strong Balance Sheet to Fund Pipeline of Omega Epigenomic Controllers™ with $122.4 Million in Cash and Cash Equivelents as of June 30, 2021 and additional $141.1 Million in Gross Proceeds from the Initial Public Offering (IPO) in the Third Quarter

September 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 10, 2021 Omega Therapeutics, Inc. (Exact Name of Registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation) (Commis

August 6, 2021 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 d209189dex991.htm EX-99.1 Exhibit 1 JOINT FILING AGREEMENT The persons below hereby agree that the Schedule 13D to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13D, shall be filed jointly on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934.

August 6, 2021 SC 13D

OMGA / Omega Therapeutics, Inc. / Flagship Ventures Fund V, L.P. - SC 13D Activist Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* OMEGA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 68217N 105 (CUSIP Number) Noubar B. Afeyan, Ph.D. Flagship Pioneering 55 Cambridge Parkway, Suite 800E Cambridge, MA 02142 (617) 868-1888 (Name, Address an

August 3, 2021 EX-3.1

Restated Certificate of Incorporation.

Exhibit 3.1 RESTATED CERTIFICATE OF INCORPORATION OF OMEGA THERAPEUTICS, INC. The name of the corporation is Omega Therapeutics, Inc. The corporation was originally incorporated by the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware on July 13, 2016 under the name VL42, Inc. This Restated Certificate of Incorporation of the corporation, whic

August 3, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 3, 2021 OMEGA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40657 81-3247585 (State or other jurisdiction of incorporation or organizat

August 3, 2021 EX-3.2

Amended and Restated Bylaws.

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF OMEGA THERAPEUTICS, INC. (a Delaware corporation) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 ADVANCE NOTICE PROCEDURES FOR BUSINESS BROUGHT BEFORE A MEETING 2 2.5 ADVANCE NOTICE PROCEDURES F

August 2, 2021 S-8

As filed with the Securities and Exchange Commission on August 2, 2021

As filed with the Securities and Exchange Commission on August 2, 2021 Registration No.

August 2, 2021 EX-4.3

Form of Restated Certificate of Incorporation of the Registrant (to be effective upon the closing of the Registrant’s initial public offering of its Common Stock).

Exhibit 4.3 RESTATED CERTIFICATE OF INCORPORATION OF OMEGA THERAPEUTICS, INC. The name of the corporation is Omega Therapeutics, Inc. The corporation was originally incorporated by the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware on July 13, 2016 under the name VL42, Inc. This Restated Certificate of Incorporation of the corporation, whic

August 2, 2021 424B4

7,400,000 Shares Omega Therapeutics, Inc. Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(4) Registration No. 333-257794 7,400,000 Shares Omega Therapeutics, Inc. Common Stock This is an initial public offering of shares of common stock of Omega Therapeutics, Inc. We are offering 7,400,000 shares of our common stock. Prior to this offering, there has been no public market for our common stock. The initial public offering price per share i

July 27, 2021 CORRESP

July 27, 2021

July 27, 2021 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

July 27, 2021 CORRESP

[Signature Page Follows]

July 27, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Omega Therapeutics, Inc. Registration Statement on Form S-1 Registration No. 333-257794 Acceleration Request Requested Date: July 29, 2021 Requested Time: 4:00 PM, Eastern Daylight Time Ladies and Gentlemen: In accordance with Rule 461 under the Securities A

July 26, 2021 EX-10.8

Form of Indemnification Agreement between Omega Therapeutics, Inc. and its directors and officers.

Exhibit 10.8 OMEGA THERAPEUTICS, INC. INDEMNIFICATION AGREEMENT THIS INDEMNIFICATION AGREEMENT (the ?Agreement?) is made and entered into as of , 2021 between Omega Therapeutics, Inc., a Delaware corporation (the ?Company?), and [Name] (?Indemnitee?). WITNESSETH THAT: WHEREAS, highly competent persons have become more reluctant to serve corporations as directors, officers or in other capacities un

July 26, 2021 EX-10.9

Shared Space Arrangement between Kintai Therapeutics, Inc. (n/k/a Senda Biosciences, Inc.) and the Registrant, dated July 13, 2020

Exhibit 10.9 SHARED SPACE ARRANGEMENT This shared space arrangement (this ?Shared Space Arrangement?) is made and entered into as of the 13th day of July, 2020 (the ?Effective Date?) by and between Kintai Therapeutics, Inc., a Delaware corporation (?Licensor?), and Omega Therapeutics, Inc., a Delaware corporation (?Licensee?), with an address as identified on the signature page of this Shared Spac

July 26, 2021 EX-10.3

2021 Employee Stock Purchase Plan.

Exhibit 10.3 OMEGA THERAPEUTICS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE The purpose of this Plan is to assist Eligible Employees of the Company and its Designated Subsidiaries in acquiring a stock ownership interest in the Company. The Plan consists of two components: (i) the Section 423 Component and (ii) the Non-Section 423 Component. The Section 423 Component is intended to q

July 26, 2021 EX-10.4

Non-Employee Director Compensation Program.

Exhibit 10.4 OMEGA THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM Non-employee members of the board of directors (the ?Board?) of Omega Therapeutics, Inc. (the ?Company?) shall receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this ?Program?). The cash and equity compensation described in this Program shall be paid or be made, as a

July 26, 2021 EX-10.15

Development and Option Agreement between Acuitas Therapeutics, Inc. and the Registrant, dated October 5, 2020, as amended

Exhibit 10.15 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED DEVELOPMENT AND OPTION AGREEMENT BETWEEN ACUITAS THERAPEUTICS, INC. AND OMEGA THERAPEUTICS, INC. EXECUTION COPY Development and Option Agreement by and between ACUITAS THERAPEUTICS, INC. and OMEGA THERAP

July 26, 2021 EX-10.2

2021 Incentive Award Plan and form of agreements thereunder.

Exhibit 10.2 OMEGA THERAPEUTICS, INC. 2021 INCENTIVE AWARD PLAN ARTICLE I. PURPOSE The Plan?s purpose is to enhance the Company?s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by providing these individuals with equity ownership opportunities and/or equity-linked compensatory opportunities. Capitalized terms used in the Pl

July 26, 2021 EX-10.17

Employment Agreement by and between Mahesh Karande and the Registrant, dated July 25, 2021.

Exhibit 10.17 Employment Agreement This Employment Agreement (this ?Agreement?), dated as of July 25, 2021, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the ?Company?), and Mahesh Karande (?Executive?) (collectively referred to herein as the ?Parties? or individually referred to as a ?Party?), and will become effective, if at all, up

July 26, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant, as amended (currently in effect)

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF OMEGA THERAPEUTICS, INC. Omega Therapeutics, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the ?Corporation?), DOES HEREBY CERTIFY: FIRST: That the Board of Directors of the Corporation duly adopted resolutions recommending and decla

July 26, 2021 EX-3.3

Form of Restated Certificate of Incorporation of the Registrant (to be effective upon the closing of this offering)

Exhibit 3.3 RESTATED CERTIFICATE OF INCORPORATION OF OMEGA THERAPEUTICS, INC. The name of the corporation is Omega Therapeutics, Inc. The corporation was originally incorporated by the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware on July 13, 2016 under the name VL42, Inc. This Restated Certificate of Incorporation of the corporation, whic

July 26, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 81-3247585 (State or incorporation or organization) (IRS Employer Identification No.) 20 Acorn Park Drive, C

July 26, 2021 S-1/A

As filed with the Securities and Exchange Commission on July 26, 2021

Table of Contents As filed with the Securities and Exchange Commission on July 26, 2021 Registration No.

July 26, 2021 EX-10.18

Employment Agreement by and between Thomas McCauley and the Registrant, dated July 24, 2021.

Exhibit 10.18 Employment Agreement This Employment Agreement (this ?Agreement?), dated as of July 24, 2021, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the ?Company?), and Thomas McCauley, Ph.D. (?Executive?) (collectively referred to herein as the ?Parties? or individually referred to as a ?Party?), and will become effective, if at

July 26, 2021 EX-4.2

Specimen Certificate of Common Stock.

EX-4.2 6 d45893dex42.htm EX-4.2 Exhibit 4.2 ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK PAR VALUE $0.001 COMMON STOCK Certificate Number ZQ00000000 Shares * * 000000 ****************** * * * 000000 ***************** **** 000000 **************** ***** 000000 *************** ****** 000000 OMEGA THERAPEUTICS, INC. INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE THIS CERTIFIE

July 26, 2021 EX-10.10

Lease Agreement between BMR-325 Vassar Street LLC and the Registrant, dated November 30, 2017.

EX-10.10 13 d45893dex1010.htm EX-10.10 Exhibit 10.10 LEASE by and between BMR-325 VASSAR STREET LLC, a Delaware limited liability company and OMEGA THERAPEUTICS, INC. a Delaware corporation BioMed Realty form dated 5/20/16 Table of Contents 1. Lease of Premises 1 2. Basic Lease Provisions 1 3. Term 3 4. Possession and Commencement Date 4 5. Condition of Premises 6 6. Rentable Area 6 7. Rent 7 8. R

July 26, 2021 EX-3.4

Form of Restated Bylaws of the Registrant (to be effective upon the closing of this offering)

Exhibit 3.4 AMENDED AND RESTATED BYLAWS OF OMEGA THERAPEUTICS, INC. (a Delaware corporation) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 ADVANCE NOTICE PROCEDURES FOR BUSINESS BROUGHT BEFORE A MEETING 2 2.5 ADVANCE NOTICE PROCEDURES F

July 26, 2021 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 Omega Therapeutics, Inc. Common Stock Underwriting Agreement [?], 2021 Goldman Sachs & Co. LLC Jefferies LLC Piper Sandler & Co. As representatives (the ?Representatives?) of the several Underwriters named in Schedule I hereto, c/o Goldman Sachs & Co. LLC 200 West Street New York, New York 10282-2198 c/o Jefferies LLC 520 Madison Avenue New York, New York 10022 c/o Piper Sandler & Co.

July 26, 2021 EX-10.11

Loan and Security Agreement between Pacific Western Bank (n/k/a PacWest Bancorp) and the Registrant, dated March 9, 2018, as amended on September 30, 2019, January 22, 2020 and December 30, 2020.

Exhibit 10.11 OMEGA THERAPEUTICS, INC. PACIFIC WESTERN BANK LOAN AND SECURITY AGREEMENT This LOAN AND SECURITY AGREEMENT (the ?Agreement?) is entered into as of March 9, 2018, by and between PACIFIC WESTERN BANK, a California state chartered bank (?Bank?) and OMEGA THERAPEUTICS, INC. (?Borrower?). RECITALS Borrower wishes to obtain credit from time to time from Bank, and Bank desires to extend cre

July 26, 2021 EX-10.19

Employment Agreement between Roger Sawhney and the Registrant, dated July 24, 2021

Exhibit 10.19 Employment Agreement This Employment Agreement (this ?Agreement?), dated as of July 24, 2021, is made by and between Omega Therapeutics, Inc., a Delaware corporation (together with any successor thereto, the ?Company?), and Roger Sawhney, M.D. (?Executive?) (collectively referred to herein as the ?Parties? or individually referred to as a ?Party?), and will become effective, if at al

July 19, 2021 CORRESP

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED BY OMEGA THERAPEUTICS, INC.

200 Clarendon Street Boston, Massachusetts 02116 Tel: +1.617.948.6000 Fax: +1.617.948.6001 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh D?sseldorf San Diego Frankfurt San Francisco Hamburg Seoul Hong Kong Shanghai Houston Silicon Valley London Singapore Los Angeles Tokyo Madrid Washington, D.C. Milan July 1

July 9, 2021 EX-10.7

Offer Letter between Roger Sawhney and the Registrant, dated March 25, 2020

Exhibit 10.7 March 25, 2020 Roger Sawhney [XXX] [XXX] Dear Roger, On behalf of Omega Therapeutics, Inc. (the ?Company?), a Flagship Pioneering Company, I am delighted to make this conditional offer of employment with the Company. This offer letter (the ?Offer Letter?) and the accompanying documents and agreements summarize and set forth important terms about your employment with the Company. 1. St

July 9, 2021 EX-10.15

Development and Option Agreement between Acuitas Therapeutics, Inc. and the Registrant, dated October 5, 2020, as amended.

EX-10.15 13 d45893dex1015.htm EX-10.15 Exhibit 10.15 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED DEVELOPMENT AND OPTION AGREEMENT BETWEEN ACUITAS THERAPEUTICS, INC. AND OMEGA THERAPEUTICS, INC. EXECUTION COPY Development and Option Agreement by and between ACUI

July 9, 2021 CORRESP

200 Clarendon Street

200 Clarendon Street Boston, Massachusetts 02116 Tel: +1.617.948.6000 Fax: +1.617.948.6001 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh D?sseldorf San Diego Frankfurt San Francisco July 9, 2021 Hamburg Seoul Hong Kong Shanghai Houston Silicon Valley London Singapore VIA EDGAR Los Angeles Tokyo Madrid Washin

July 9, 2021 EX-4.3

Amended and Restated Warrant to Purchase Stock issued to PacWest Bankcorp, dated September 30, 2019, to purchase Series A preferred stock.

Exhibit 4.3 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS, AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS, OR PURSUANT TO RULE 144 OR AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF

July 9, 2021 EX-4.1

Amended and Restated Investor Rights’ Agreement, dated March 4, 2021.

EX-4.1 4 d45893dex41.htm EX-4.1 Exhibit 4.1 SECOND AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT THIS SECOND AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (the “Agreement”) is made as of March 4, 2021, by and among Omega Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the investors listed on Schedule A hereto (each of which is referred to in this Agreement as an “Inve

July 9, 2021 EX-10.14

Co-Exclusive License Agreement between the Whitehead Institute for Biomedical Research and the Registrant, dated May 22, 2019.

EX-10.14 12 d45893dex1014.htm EX-10.14 Exhibit 10.14 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH PATENT LICENSE AGREEMENT (CO-EXCLUSIVE) This Agreement, effective as of May 22, 2019 (the “EFFECTIVE DATE”), is between

July 9, 2021 EX-10.5

Offer Letter between Mahesh Karande and the Registrant, dated March 2, 2019

Exhibit 10.5 215 First Street, Suite 400-S Cambridge, MA 02142 617.949.4360 omegatherapeutics.com March 2, 2019 Mahesh Karande [XXX] [XXX] Dear Mahesh, On behalf of Omega Therapeutics (the ?Company?), a Flagship Pioneering Company, I am delighted to make this conditional offer of employment with the Company. This offer letter (the ?Offer Letter?) and the accompanying documents and agreements summa

July 9, 2021 EX-10.6

Offer Letter between Tom McCauley and the Registrant, dated July 10, 2019

Exhibit 10.6 July 10, 2019 Tom McCauley [XXX] [XXX] Dear Tom, On behalf of Omega Therapeutics, Inc. (the ?Company?), a Flagship Pioneering Company, I am delighted to make this conditional offer of employment with the Company. This offer letter (the ?Offer Letter?) and the accompanying documents and agreements summarize and set forth important terms about your employment with the Company. 1. Starti

July 9, 2021 EX-3.2

Bylaws of the Registrant (currently in effect)

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF OMEGA THERAPEUTICS, INC. TABLE OF CONTENTS Page ARTICLE I STOCKHOLDERS 1 1.1 Place of Meetings 1 1.2 Annual Meeting 1 1.3 Special Meetings 1 1.4 Notice of Meetings 1 1.5 Voting List 1 1.6 Quorum 2 1.7 Adjournments 2 1.8 Voting and Proxies 2 1.9 Action at Meeting 3 1.10 Conduct of Meetings 3 1.11 Action without Meeting 4 ARTICLE II DIRECTORS 5 2.1 General

July 9, 2021 EX-10.12

License Agreement between Flagship Pioneering Innovations V, Inc. and the Registrant, dated March 12, 2019.

EX-10.12 10 d45893dex1012.htm EX-10.12 Exhibit 10.12 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED Execution Copy LICENSE AGREEMENT This License Agreement (this “Agreement”), effective on March 12, 2019 (the “Effective Date”) is by and between Flagship Pioneering

July 9, 2021 EX-10.1

2017 Equity Incentive Plan, as amended, and form of option agreements thereunder

Exhibit 10.1 OMEGA THERAPEUTICS, INC. 2017 EQUITY INCENTIVE PLAN ARTICLE I. PURPOSE. The purpose of the Plan is to advance the interests of the Company?s stockholders by enhancing the Company?s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by providing such persons with equity ownership opportunities and thereby better ali

July 9, 2021 EX-10.13

Exclusive License Agreement between the Whitehead Institute for Biomedical Research and the Registrant, dated May 22, 2019.

Exhibit 10.13 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH PATENT LICENSE AGREEMENT This Agreement, effective as of May 22, 2019 (the ?EFFECTIVE DATE?), is between the Whitehead Institute for Biomedical Research (?WHIT

July 9, 2021 S-1

Power of Attorney (included on signature page)

Table of Contents As filed with the Securities and Exchange Commission on July 9, 2021 Registration No.

July 9, 2021 EX-10.16

Non-Exclusive License Agreement between Acuitas Therapeutics, Inc. and the Registrant, dated March 22, 2021.

EX-10.16 14 d45893dex1016.htm EX-10.16 Exhibit 10.16 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED NON-EXCLUSIVE LICENSE AGREEMENT BETWEEN ACUITAS THERAPEUTICS, INC. AND OMEGA THERAPEUTICS, INC. MYC EXECUTION COPY NON-EXCLUSIVE LICENSE AGREEMENT by and between AC

July 9, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant, as amended (currently in effect)

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF OMEGA THERAPEUTICS, INC. Pursuant to Section 242 of the General Corporation Law of the State of Delaware Omega Therapeutics, Inc. (the ?Corporation?), a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY: 1.

July 2, 2021 EX-10.14

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH PATENT LICENSE AGREEMENT (CO-EXCLUSIVE)

EX-10.14 4 filename4.htm Exhibit 10.14 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH PATENT LICENSE AGREEMENT (CO-EXCLUSIVE) This Agreement, effective as of May 22, 2019 (the “EFFECTIVE DATE”), is between the Whitehead

July 2, 2021 DRS/A

As confidentially submitted to the Securities and Exchange Commission on July 2, 2021 as Amendment No. 2 to the Draft Registration Statement

DRS/A 1 filename1.htm As confidentially submitted to the Securities and Exchange Commission on July 2, 2021 as Amendment No. 2 to the Draft Registration Statement Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter

July 2, 2021 EX-10.15

Development and Option Agreement by and between ACUITAS THERAPEUTICS, INC. OMEGA THERAPEUTICS, INC. October 5, 2020

Exhibit 10.15 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED DEVELOPMENT AND OPTION AGREEMENT BETWEEN ACUITAS THERAPEUTICS, INC. AND OMEGA THERAPEUTICS, INC. EXECUTION COPY Development and Option Agreement by and between ACUITAS THERAPEUTICS, INC. and OMEGA THERAP

July 2, 2021 EX-10.13

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH PATENT LICENSE AGREEMENT

EX-10.13 3 filename3.htm Exhibit 10.13 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH PATENT LICENSE AGREEMENT This Agreement, effective as of May 22, 2019 (the “EFFECTIVE DATE”), is between the Whitehead Institute for B

July 2, 2021 EX-10.16

NON-EXCLUSIVE LICENSE AGREEMENT by and between ACUITAS THERAPEUTICS, INC. OMEGA THERAPEUTICS, INC. March 22, 2021

EX-10.16 6 filename6.htm Exhibit 10.16 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED NON-EXCLUSIVE LICENSE AGREEMENT BETWEEN ACUITAS THERAPEUTICS, INC. AND OMEGA THERAPEUTICS, INC. MYC EXECUTION COPY NON-EXCLUSIVE LICENSE AGREEMENT by and between ACUITAS THERAPEU

July 2, 2021 EX-10.12

LICENSE AGREEMENT

Exhibit 10.12 CERTAIN CONFIDENTIAL INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED Execution Copy LICENSE AGREEMENT This License Agreement (this ?Agreement?), effective on March 12, 2019 (the ?Effective Date?) is by and between Flagship Pioneering Innovations V, Inc., a Delaware corpor

June 22, 2021 EX-10.6

[Signature Page Follows]

Exhibit 10.6 July 10, 2019 Tom McCauley [XXX] [XXX] Dear Tom, On behalf of Omega Therapeutics, Inc. (the ?Company?), a Flagship Pioneering Company, I am delighted to make this conditional offer of employment with the Company. This offer letter (the ?Offer Letter?) and the accompanying documents and agreements summarize and set forth important terms about your employment with the Company. 1. Starti

June 22, 2021 EX-3.1

CERTIFICATE OF AMENDMENT AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OMEGA THERAPEUTICS, INC. Pursuant to Section 242 of the General Corporation Law of the State of Delaware

EX-3.1 2 filename2.htm Exhibit 3.1 CERTIFICATE OF AMENDMENT TO AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF OMEGA THERAPEUTICS, INC. Pursuant to Section 242 of the General Corporation Law of the State of Delaware Omega Therapeutics, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware, D

June 22, 2021 DRS/A

As confidentially submitted to the Securities and Exchange Commission on June 21, 2021 as Amendment No. 1 to the Draft Registration Statement

DRS/A 1 filename1.htm Table of Contents As confidentially submitted to the Securities and Exchange Commission on June 21, 2021 as Amendment No. 1 to the Draft Registration Statement Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Omega Therapeutics, Inc. (Exact name of registrant as speci

June 22, 2021 EX-10.5

[Signature Page Follows]

EX-10.5 7 filename7.htm Exhibit 10.5 215 First Street, Suite 400-S Cambridge, MA 02142 617.949.4360 omegatherapeutics.com March 2, 2019 Mahesh Karande [XXX] [XXX] Dear Mahesh, On behalf of Omega Therapeutics (the “Company”), a Flagship Pioneering Company, I am delighted to make this conditional offer of employment with the Company. This offer letter (the “Offer Letter”) and the accompanying docume

June 22, 2021 EX-3.2

AMENDED AND RESTATED OMEGA THERAPEUTICS, INC.

EX-3.2 3 filename3.htm Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF OMEGA THERAPEUTICS, INC. TABLE OF CONTENTS Page ARTICLE I STOCKHOLDERS 1 1.1 Place of Meetings 1 1.2 Annual Meeting 1 1.3 Special Meetings 1 1.4 Notice of Meetings 1 1.5 Voting List 1 1.6 Quorum 2 1.7 Adjournments 2 1.8 Voting and Proxies 2 1.9 Action at Meeting 3 1.10 Conduct of Meetings 3 1.11 Action without Meeting 4 ARTICLE II D

June 22, 2021 EX-4.3

AMENDED AND RESTATED WARRANT TO PURCHASE STOCK Corporation: OMEGA THERAPEUTICS, INC. Number of Shares: 350,000 Class of Stock: Series A Preferred Stock Initial Exercise Price: $0.50 per share Original Issue Date: March 9, 2018 Restatement Date: Septe

Exhibit 4.3 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS, AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS, OR PURSUANT TO RULE 144 OR AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF

June 22, 2021 EX-10.1

OMEGA THERAPEUTICS, INC. 2017 EQUITY INCENTIVE PLAN

Exhibit 10.1 OMEGA THERAPEUTICS, INC. 2017 EQUITY INCENTIVE PLAN ARTICLE I. PURPOSE. The purpose of the Plan is to advance the interests of the Company?s stockholders by enhancing the Company?s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by providing such persons with equity ownership opportunities and thereby better ali

June 22, 2021 EX-10.7

1

EX-10.7 9 filename9.htm Exhibit 10.7 March 25, 2020 Roger Sawhney [XXX] [XXX] Dear Roger, On behalf of Omega Therapeutics, Inc. (the “Company”), a Flagship Pioneering Company, I am delighted to make this conditional offer of employment with the Company. This offer letter (the “Offer Letter”) and the accompanying documents and agreements summarize and set forth important terms about your employment

June 22, 2021 EX-4.1

SECOND AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

Exhibit 4.1 SECOND AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT THIS SECOND AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT (the ?Agreement?) is made as of March 4, 2021, by and among Omega Therapeutics, Inc., a Delaware corporation (the ?Company?), and each of the investors listed on Schedule A hereto (each of which is referred to in this Agreement as an ?Investor?, and together with any sub

June 21, 2021 DRSLTR

2

June 21, 2021 VIA EDGAR Division of Corporation Finance Office of Life Sciences United States Securities and Exchange Commission 100 F Street, N.

May 10, 2021 DRS

As confidentially submitted to the Securities and Exchange Commission on May 7, 2021

DRS 1 filename1.htm Table of Contents As confidentially submitted to the Securities and Exchange Commission on May 7, 2021 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Omega Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 2836 81-3247585 (State or oth

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