TNYA / Tenaya Therapeutics, Inc. - Pemfailan SEC, Laporan Tahunan, Penyata Proksi

Tenaya Therapeutics, Inc.
US ˙ NasdaqGS ˙ US87990A1060

Statistik Asas
CIK 1858848
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Tenaya Therapeutics, Inc.
SEC Filings (Chronological Order)
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August 6, 2025 8-K

FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 06, 2025 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commissi

August 6, 2025 10-Q

The accompanying notes are an integral part of these unaudited condensed financial statements. The accompanying notes are an integral part of these unaudited condensed financial statements. The accompanying notes are an integral part of these unaudit

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

August 6, 2025 EX-99.1

Tenaya Therapeutics Reports Second Quarter 2025 Financial Results and Provides Business Update Enrollment Complete in Cohorts 1 and 2 of MyPEAKTM-1 Phase 1b/2 Trial of TN-201 for MYBPC3-associated HCM; Positive DSMB Safety Review Enables Enrollment o

Exhibit 99.1 Tenaya Therapeutics Reports Second Quarter 2025 Financial Results and Provides Business Update Enrollment Complete in Cohorts 1 and 2 of MyPEAKTM-1 Phase 1b/2 Trial of TN-201 for MYBPC3-associated HCM; Positive DSMB Safety Review Enables Enrollment of Expansion Cohorts Cohort 1 of RIDGE™-1 Phase 1b Trial of TN-401 Enrolled and First PKP2-associated ARVC Patient Dosed in Cohort 2 Follo

May 30, 2025 8-K

FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2025 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commission

May 7, 2025 10-Q

The accompanying notes are an integral part of these unaudited condensed financial statements. The accompanying notes are an integral part of these unaudited condensed financial statements. The accompanying notes are an integral part of these unaudit

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

May 7, 2025 EX-99.1

Tenaya Therapeutics Reports First Quarter 2025 Financial Results and Provides Business Update Interim Data from Low Dose Cohort in MyPEAKTM-1 Clinical Trial of TN-201 Showed Encouraging Safety Profile, Transduction and Expression, Plus Improvements i

Exhibit 99.1 Tenaya Therapeutics Reports First Quarter 2025 Financial Results and Provides Business Update Interim Data from Low Dose Cohort in MyPEAKTM-1 Clinical Trial of TN-201 Showed Encouraging Safety Profile, Transduction and Expression, Plus Improvements in Hypertrophy and NYHA Classification RIDGE Natural History and Seroprevalence Study Highlights Significant Disease Burden and Unmet Need

May 7, 2025 8-K

FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 07, 2025 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commission

April 18, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2025 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commissio

April 17, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Pro

April 17, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defi

March 28, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 27, 2025 Tenaya Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 27, 2025 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissio

March 27, 2025 CORRESP

March 27, 2025

CORRESP March 27, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, DC 20549-3720 Attention: Joshua Gorsky Re: Tenaya Therapeutics, Inc. Registration Statement on Form S-3 Filed March 21, 2025 File No. 333-286005 Acceleration Request Requested Date: March 31, 2025 Requested Time: 4:00 P.M. Eastern Time, or

March 21, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLES Form S-3 (Form Type) Tenaya Therapeutics, Inc.

March 21, 2025 EX-4.5

Form of Indenture

Exhibit 4.5 TENAYA THERAPEUTICS, INC. INDENTURE Dated as of    , 20 [] Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1 Definitions 1 Section 1.2 Other Definitions 4 Section 1.3 Incorporation by Reference of Trust Indenture Act 5 Section 1.4 Rules of Construction 5 ARTICLE II THE SECURITIES 5 Section 2.1 Issuable in Series 5 Section 2.2 Establishmen

March 21, 2025 S-3

As filed with the Securities and Exchange Commission on March 21, 2025

S-3 Table of Contents As filed with the Securities and Exchange Commission on March 21, 2025 Registration No.

March 10, 2025 EX-4.3

Description of Securities

Exhibit 4.3 Description of Securities General Tenaya Therapeutics, Inc. (“we,” “our,” or “us”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): our common stock, $0.0001 par value per share. The following descriptions of our capital stock and certain provisions of our amended and restated certificate of incorporation a

March 10, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2025 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commissio

March 10, 2025 EX-99.1

Tenaya Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update Dosing Initiated in Cohort 2 of the MyPEAK™-1 Phase 1b/2 Clinical Trial of TN-201 for Treatment of MYBPC3-Associated Hypertrophic Cardiomyopa

Exhibit 99.1 Tenaya Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update Dosing Initiated in Cohort 2 of the MyPEAK™-1 Phase 1b/2 Clinical Trial of TN-201 for Treatment of MYBPC3-Associated Hypertrophic Cardiomyopathy MyPEAK-1 Cohort 1 Data Accepted for Late-Breaker Presentation at the American College of Cardiology Meeting Initial Data from RIDGE™-

March 10, 2025 EX-19.1

Insider Trading Policy

EXHIBIT 19.1 TENAYA THERAPEUTICS, INC. INSIDER TRADING POLICY A. POLICY OVERVIEW Tenaya Therapeutics, Inc. (the “Company”) has adopted this Insider Trading Policy (the “Policy”) to help Covered Persons (as defined below) comply with the federal and state securities laws and regulations that govern trading in securities and to help the Company minimize its own legal and reputational risk. It is eac

March 10, 2025 EX-10.10

Employment Letter between the Registrant and Tomohiro Higa, M.B.A.

EXHIBIT 10.10 171 Oyster Point Boulevard, Suite 500 South San Francisco, CA 94080 November 26, 2019 Tomohiro Higa Dear Hiro: I am pleased to offer you a position with Tenaya Therapeutics, Inc. (the "Company"), as its Vice President, Finance reporting to Faraz Ali, M.B.A., Chief Executive Officer. If you accept our offer, your first day of employment will be as soon as practicable, but no later tha

March 10, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROMTO Commission File Number 001-40656 TENAYA THERAPEUT

March 4, 2025 EX-4.2

Form of Series B Warrant to Purchase Common Stock

Exhibit 4.2 TENAYA THERAPEUTICS, INC. FORM OF SERIES B WARRANT TO PURCHASE COMMON STOCK Number of Shares: [ ] (subject to adjustment) Warrant No. B-[ ] Original Issue Date: March [ ], 2025 Tenaya Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its registered

March 4, 2025 424B5

75,000,000 UNITS CONSISTING OF ONE SHARE OF COMMON STOCK, ONE SERIES A WARRANT TO PURCHASE COMMON STOCK AND ONE SERIES B WARRANT TO PURCHASE COMMON STOCK SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE SERIES A WARRANTS AND SERIES B WARRANTS

Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-266741 PROSPECTUS SUPPLEMENT (To prospectus dated August 17, 2022) 75,000,000 UNITS CONSISTING OF ONE SHARE OF COMMON STOCK, ONE SERIES A WARRANT TO PURCHASE COMMON STOCK AND ONE SERIES B WARRANT TO PURCHASE COMMON STOCK SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE SERIES A WARRANTS AND SERIES B WARRANTS We are off

March 4, 2025 EX-1.1

Underwriting Agreement between the Company, Leerink Partners LLC and Piper Sandler & Co., dated as of March 3, 2025.

Exhibit 1.1 TENAYA THERAPEUTICS, INC. 75,000,000 UNITS CONSISTING OF ONE SHARE OF COMMON STOCK, ONE SERIES A WARRANT TO PURCHASE ONE SHARE OF COMMON STOCK AND ONE SERIES B WARRANT TO PURCHASE ONE-HALF OF A SHARE OF COMMON STOCK UNDERWRITING AGREEMENT March 3, 2025 March 3, 2025 Leerink Partners LLC Piper Sandler & Co. As Representatives of the several Underwriters named in Schedule I hereto c/o Le

March 4, 2025 EX-4.1

Form of Series A Warrant to Purchase Common Stock

Exhibit 4.1 TENAYA THERAPEUTICS, INC. FORM OF SERIES A WARRANT TO PURCHASE COMMON STOCK Number of Shares: [ ] (subject to adjustment) Warrant No. A-[ ] Original Issue Date: March [ ], 2025 Tenaya Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its registered

March 4, 2025 EX-99.1

Tenaya Therapeutics Announces Pricing of Public Offering

Exhibit 99.1 Tenaya Therapeutics Announces Pricing of Public Offering South San Francisco, Calif. – March 3, 2025 – Tenaya Therapeutics, Inc. (Nasdaq: TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today announced the pricing of its underwritten public offering of 75,0

March 4, 2025 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2025 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

March 3, 2025 424B5

SUBJECT TO COMPLETION, DATED MARCH 3, 2025

424B5 Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-266741 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to

March 3, 2025 424B3

Tenaya Therapeutics, Inc.

424B3 Filed pursuant to Rule 424(b)(3) Registration No. 333-266741 SUPPLEMENT NO 1. DATED March 3, 2025 TO PROSPECTUS SUPPLEMENT DATED August 17, 2022 (To Prospectus Dated August 17, 2022) Tenaya Therapeutics, Inc. This Supplement No. 1 to Prospectus Supplement (this “Supplement”) supplements and amends the Prospectus Supplement dated August 17, 2022 (the “Prospectus Supplement”). This Supplement

February 14, 2025 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ex-99-02142025110237.htm JOINT FILING AGREEMENT EXHIBIT 99.1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of February 14, 2025, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the “Filers”). Each of the Filers may be required to file with the United State

February 7, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Tenaya Therapeutics, Inc.

February 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 06, 2025 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commis

February 7, 2025 S-8

As filed with the Securities and Exchange Commission on February 7, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 TENAYA THERAPEUTICS, INC. (Exact name of

As filed with the Securities and Exchange Commission on February 7, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

January 28, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 24, 2025 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commiss

December 17, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 16, 2024 Tenaya Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 16, 2024 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

December 17, 2024 EX-99.1

Tenaya Therapeutics Reports Promising Early Data from MyPEAK™-1 Phase 1b/2 Clinical Trial of TN-201 for Treatment of MYBPC3-Associated Hypertrophic Cardiomyopathy TN-201 Well Tolerated at 3E13 vg/kg Dose AAV9 Capsid Demonstrated Robust Delivery of TN

Exhibit 99.1 Tenaya Therapeutics Reports Promising Early Data from MyPEAK™-1 Phase 1b/2 Clinical Trial of TN-201 for Treatment of MYBPC3-Associated Hypertrophic Cardiomyopathy TN-201 Well Tolerated at 3E13 vg/kg Dose AAV9 Capsid Demonstrated Robust Delivery of TN-201 Transgene to Heart Muscle Cells Resulting in Increasing RNA Expression and an Increase in Protein Levels Observed at One Year Circul

December 17, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 17, 2024 Tenaya Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 17, 2024 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

December 17, 2024 EX-99.2

Phase 1b Study Initial Cohort 1 Data December 17, 2024 

Exhibit 99.2 TN-201 MyPEAK-1 Phase 1b Study Initial Cohort 1 Data December 17, 2024  Today’s speakers Milind Desai, M.D., Director at the Cleveland Clinical Faraz Ali, MBA HCM Center; Vice Chair of Heart Chief Executive Officer Vascular Thoracic Institute and MyPEAK-1 investigator Michelle Corral Whit Tingley, M.D., PhD Vice President, Corporate Chief Medical Officer Communications and Investor Re

November 14, 2024 SC 13G/A

TNYA / Tenaya Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm2427451d24sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 87990A106 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Stat

November 14, 2024 EX-99.1

Exhibit 1: Joint Filing Agreement

EX-99.1 2 tm2427451d24ex1.htm EXHIBIT 1 EXHIBIT 1 AGREEMENT This Joint Filing Agreement, dated as of November 14, 2024, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the “Filers”). Each of the Filers may be required to file with the United States Securities and Exchange Commissi

November 6, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 06, 2024 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commis

November 6, 2024 EX-99.1

Tenaya Therapeutics Reports Third Quarter 2024 Financial Results and Provides Business Update Data Safety and Monitoring Board Endorsed Dose Escalation and Broadening of Inclusion Criteria in the MyPEAKTM-1 Phase 1b/2 Trial of TN-201 Gene Therapy Ini

Exhibit 99.1 Tenaya Therapeutics Reports Third Quarter 2024 Financial Results and Provides Business Update Data Safety and Monitoring Board Endorsed Dose Escalation and Broadening of Inclusion Criteria in the MyPEAKTM-1 Phase 1b/2 Trial of TN-201 Gene Therapy Initial TN-201 Data from Cohort 1 of MyPEAK-1 to be Reported in December 2024 SOUTH SAN FRANCISCO, Calif., November 6, 2024 – Tenaya Therape

November 6, 2024 EX-4.1

Warrant to Purchase Stock

Exhibit 4.1 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 6.3 AND 6.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTAN

November 6, 2024 EX-10.1

Loan and Security Agreement by and between Silicon Valley Bank, a division of First-Citizens Bank & Trust Company and Tenaya Therapeutics, Inc.

Exhibit 10.1 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED. [***] INDICATES THAT INFORMATION HAS BEEN REDACTED. LOAN AND SECURITY AGREEMENT This LOAN AND SECURITY AGREEMENT (this “Agreement”) is dated as of the Effective Date between SILICON VALLEY BANK, A DIVISION OF FIR

November 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

September 17, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Tenaya Therapeutics, Inc.

September 17, 2024 S-8

As filed with the Securities and Exchange Commission on September 16, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 TENAYA THERAPEUTICS, INC. (Exact name of reg

As filed with the Securities and Exchange Commission on September 16, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

September 16, 2024 EX-10.1

Tenaya Therapeutics, Inc. 2024 Inducement Equity Incentive Plan and related forms of stock option and restricted stock unit agreements

Exhibit 10.1 TENAYA THERAPEUTICS, INC. 2024 INDUCEMENT EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purpose of this Plan is to attract and retain the best available personnel for positions of substantial responsibility by providing an inducement material to individuals entering into employment with the Company or any Parent or Subsidiary of the Company. The Plan permits the grant of Nonstatu

September 16, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2024 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commi

August 8, 2024 EX-99.1

Tenaya Therapeutics Reports Second Quarter 2024 Financial Results and Provides Business Update Received Rare Pediatric Disease Designation from U.S. Food and Drug Administration for TN-201 for MYBPC3-associated Hypertrophic Cardiomyopathy Received UK

Exhibit 99.1 Tenaya Therapeutics Reports Second Quarter 2024 Financial Results and Provides Business Update Received Rare Pediatric Disease Designation from U.S. Food and Drug Administration for TN-201 for MYBPC3-associated Hypertrophic Cardiomyopathy Received UK Clearance to Initiate Clinical Testing of TN-401 for PKP2-Associated Arrhythmogenic Right Ventricular Cardiomyopathy Established $45 Mil

August 8, 2024 EX-10.1

First Amendment to Lease between HCP Oyster Point III LLC and the Registrant dated as of September 6, 2016.

Exhibit 10.1 FIRST AMENDMENT TO LEASE This FIRST AMENDMENT TO LEASE ("First Amendment") is made and entered into as of June 14, 2024, by and between HCP OYSTER POINT III LLC, a Delaware limited liability company ("Landlord"), and TENAYA THERAPEUTICS, INC., a Delaware corporation ("Tenant"). r e c i t a l s : A. Landlord and Tenant (as successor-in-interest to The Column Group, LLC) are parties to

August 8, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 08, 2024 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commissi

August 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

July 25, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 19, 2024 Tenaya Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 19, 2024 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

June 27, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2024 Tenaya Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40656 81-3789973 (State or Other Jurisdiction of Incorporation) (Commission

May 31, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 30, 2024 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

May 14, 2024 EX-99.1

Tenaya Therapeutics Reports First Quarter 2024 Financial Results and Provides Business Update Initial Data from Ongoing MyPEAKTM-1 Phase 1b of TN-201 Expected in Second Half of 2024 Clinical Sites Activated for RIDGETM-1 Phase 1b Clinical Trial of TN

Exhibit 99.1 Tenaya Therapeutics Reports First Quarter 2024 Financial Results and Provides Business Update Initial Data from Ongoing MyPEAKTM-1 Phase 1b of TN-201 Expected in Second Half of 2024 Clinical Sites Activated for RIDGETM-1 Phase 1b Clinical Trial of TN-401 Announced Cost Containment Measures in Alignment with Focus on Generating Data from Clinical-Stage Gene Therapy Programs Raised $47

May 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

May 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2024 Tenaya Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2024 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

April 17, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒         Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)

April 17, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

March 18, 2024 EX-10.10

Outside Director Compensation Policy.

Exhibit 10.10 TENAYA THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY (as most recently amended December 7, 2023) Tenaya Therapeutics, Inc. (the “Company”) believes that the granting of equity and cash compensation to members of the Company’s Board of Directors (the “Board,” and members of the Board, “Directors”) represents an effective tool to attract, retain and reward Directors who are n

March 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2024 Tenaya Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2024 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissio

March 18, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROMTO Commission File Number 001-40656 TENAYA THERAPE

March 18, 2024 EX-97

Compensation Recovery Policy.

Exhibit 97 Tenaya Therapeutics, Inc. COMPENSATION RECOVERY POLICY As adopted on November 21, 2023 Tenaya Therapeutics, Inc. (the “Company”) is committed to strong corporate governance. As part of this commitment, the Compensation Committee (the “Committee”) of the Company’s Board of Directors (the “Board”) has adopted this clawback policy called the Compensation Recovery Policy (the “Policy”). The

March 18, 2024 EX-99.1

Tenaya Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update Initial Data from Ongoing MyPeak™-1 Phase 1b of TN-201 for MYBPC3-associated HCM Expected in Second Half of 2024 On Track to Dose First Patie

Exhibit 99.1 Tenaya Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update Initial Data from Ongoing MyPeak™-1 Phase 1b of TN-201 for MYBPC3-associated HCM Expected in Second Half of 2024 On Track to Dose First Patient in RIDGE™-1Phase 1b Clinical Trial of TN-401 for PKP2-associated ARVC in Second Half 2024 $47 Million Net Proceeds from Recent Financi

February 14, 2024 EX-99.1

Exhibit 1: Joint Filing Agreement

EXHIBIT 1 AGREEMENT This Joint Filing Agreement, dated as of February 14, 2024, is by and among RA Capital Management, L.

February 14, 2024 SC 13G/A

TNYA / Tenaya Therapeutics, Inc. / RTW INVESTMENTS, LP - TENAYA THERAPEUTICS, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 87990A106 (CUSIP Number) December 31, 2023 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pur

February 14, 2024 SC 13D/A

TNYA / Tenaya Therapeutics, Inc. / COLUMN GROUP III, LP - SC 13D/A Activist Investment

SC 13D/A 1 d726884dsc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* TENAYA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 87990A106 (CUSIP Number) James Evangelista The Column Group 1 Letterman Drive, Building D, Suite DM-900 San F

February 14, 2024 SC 13G/A

TNYA / Tenaya Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 87990A106 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designat

February 8, 2024 EX-4.1

Form of Pre-Funded Warrant

EX-4.1 Exhibit 4.1 TENAYA THERAPEUTICS, INC. FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK Number of Shares: [ ] (subject to adjustment) Warrant No. Original Issue Date: [ ], 2024 Tenaya Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its registered ass

February 8, 2024 EX-99.1

Tenaya Therapeutics Announces Pricing of Underwritten Offering

Exhibit 99.1 Tenaya Therapeutics Announces Pricing of Underwritten Offering South San Francisco, Calif. – February 8, 2024 – Tenaya Therapeutics, Inc. (Nasdaq: TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today announced the pricing of its underwritten offering of 8,

February 8, 2024 EX-1.1

Underwriting Agreement between the Company, Leerink Partners LLC and Cowen and Company, LLC, dated as of February 7, 2024.

Exhibit 1.1 TENAYA THERAPEUTICS, INC. 8,888,890 SHARES OF COMMON STOCK, $0.0001 PAR VALUE PER SHARE PRE-FUNDED WARRANTS TO PURCHASE 2,222,271 SHARES OF COMMON STOCK UNDERWRITING AGREEMENT February 7, 2024 February 7, 2024 Leerink Partners LLC Cowen and Company, LLC As Representatives of the several Underwriters named in Schedule I hereto c/o Leerink Partners LLC 1301 Avenue of the Americas, 12th F

February 8, 2024 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 7, 2024 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commiss

February 8, 2024 424B5

8,888,890 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 2,222,271 SHARES OF COMMON STOCK

Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-266741 PROSPECTUS SUPPLEMENT (To prospectus dated August 17, 2022) 8,888,890 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 2,222,271 SHARES OF COMMON STOCK We are offering an aggregate of 8,888,890 shares of our common stock and, in lieu of common stock to certain investors that so choose, pre-funded warrants to purch

January 31, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Tenaya Therapeutics, Inc.

January 31, 2024 S-8

As filed with the Securities and Exchange Commission on January 31, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 TENAYA THERAPEUTICS, INC. (Exact name of regis

As filed with the Securities and Exchange Commission on January 31, 2024 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

November 8, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

November 8, 2023 EX-10.1

Outside Director Compensation Policy

Exhibit 10.1 TENAYA THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY (as most recently amended September 14, 2023) Tenaya Therapeutics, Inc. (the “Company”) believes that the granting of equity and cash compensation to members of the Company’s Board of Directors (the “Board,” and members of the Board, “Directors”) represents an effective tool to attract, retain and reward Directors who are

November 8, 2023 EX-99.1

Tenaya Therapeutics Reports Third Quarter 2023 Financial Results and Provides Business Update Commenced Patient Dosing in MyPeak-1TM Phase 1b Trial of TN-201 in MYBPC3-Associated Hypertrophic Cardiomyopathy Presented Positive Phase 1 Data for TN-301

Exhibit 99.1 Tenaya Therapeutics Reports Third Quarter 2023 Financial Results and Provides Business Update Commenced Patient Dosing in MyPeak-1TM Phase 1b Trial of TN-201 in MYBPC3-Associated Hypertrophic Cardiomyopathy Presented Positive Phase 1 Data for TN-301 for the Potential Treatment of Heart Failure with Preserved Ejection Fraction at HFSA 2023 TN-401 for PKP2-Associated ARVC Received FDA C

November 8, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2023 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commiss

August 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2023 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissio

August 9, 2023 EX-3.1

Composite Amended and Restated Certificate of Incorporation of Tenaya Therapeutics, Inc., as amended

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TENAYA THERAPEUTICS, INC. a Delaware corporation Tenaya Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Company”), does hereby certify as follows: A. The original Certificate of Incorporation of the Company was filed with the Secretary of State of the State of Delaware on August

August 9, 2023 EX-99.1

Tenaya Therapeutics Reports Second Quarter 2023 Financial Results and Provides Business Update Dosing of First Patient in Phase 1b Trial of TN-201 On Track to Occur in Q3 2023 Data from Phase 1 Clinical Trial of TN-301 Accepted for Presentation at HF

Exhibit 99.1 Tenaya Therapeutics Reports Second Quarter 2023 Financial Results and Provides Business Update Dosing of First Patient in Phase 1b Trial of TN-201 On Track to Occur in Q3 2023 Data from Phase 1 Clinical Trial of TN-301 Accepted for Presentation at HFSA 2023 IND Application for TN-401 Anticipated in Second Half 2023 Second Quarter Cash and Investments of $152 Million; Runway to Fund Op

August 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

June 12, 2023 EX-10.1

Executive Change in Control and Severance Plan.

Exhibit 10.1 TENAYA THERAPEUTICS, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE PLAN AND SUMMARY PLAN DESCRIPTION 1. Introduction. The purpose of this Tenaya Therapeutics, Inc. Executive Change in Control and Severance Plan (the “Plan”) is to provide assurances of specified benefits to certain employees of the Company whose employment could be being involuntarily terminated other than for death,

June 12, 2023 EX-3.1

Certificate of Amendment of Amended and Restated Certificate of Incorporation of Tenaya Therapeutics, Inc.

Exhibit 3.1 Certificate of Amendment to THE Amended and Restated Certificate of Incorporation of TENAYA THERAPEUTICS, Inc. Tenaya Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), hereby certifies as follows: 1. The name of the Corporation is Tenaya Therapeutics, Inc. The original Certificate of Incorporation of the Corporation wa

June 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 Tenaya Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

May 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2023 Tenaya Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2023 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

May 10, 2023 EX-99

Tenaya Therapeutics Reports First Quarter 2023 Financial Results and Provides Business Update TN-201 Received Fast Track Designation from the FDA Dosing Complete in Phase 1 Clinical Trial of TN-301; Data Expected in Second Half 2023 Renowned Research

Exhibit 99.1 Tenaya Therapeutics Reports First Quarter 2023 Financial Results and Provides Business Update TN-201 Received Fast Track Designation from the FDA Dosing Complete in Phase 1 Clinical Trial of TN-301; Data Expected in Second Half 2023 Renowned Researchers Drs. Christine Seidman and Alex Marson Join Scientific Advisory Board Announces Formation of Technical Advisory Board with Deep Exper

May 10, 2023 EX-10

Outside Director Compensation Policy

Exhibit 10.1 TENAYA THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY (as most recently amended and restated March 16, 2023 (the “Restatement Date”)) Tenaya Therapeutics, Inc. (the “Company”) believes that the granting of equity and cash compensation to members of the Company’s Board of Directors (the “Board,” and members of the Board, “Directors”) represents an effective tool to attract, re

May 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

April 27, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 27, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Pro

April 17, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

PRE 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 21, 2023 EX-3

Amended and Restated Bylaws of Tenaya Therapeutics, Inc.

Exhibit 3.1 AMENDED AND RESTATED BYLAWS OF TENAYA THERAPEUTICS, INC. (initially adopted on August 18, 2016) (as amended and restated on August 3, 2021 and March 16, 2023) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 ADVANCE NOTICE PROC

March 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 Tenaya Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissio

March 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Tenaya Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissio

March 8, 2023 S-8

As filed with the Securities and Exchange Commission on March 8, 2023 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 TENAYA THERAPEUTICS, INC. (Exact name of registra

As filed with the Securities and Exchange Commission on March 8, 2023 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 8, 2023 EX-99

Tenaya Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Business Update TN-201 IND Cleared in January; Plan to Begin Phase 1b Dosing in MYBPC3-associated HCM Patients in Third Quarter 2023 Dosing Commenced in Mult

Exhibit 99.1 Tenaya Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Business Update TN-201 IND Cleared in January; Plan to Begin Phase 1b Dosing in MYBPC3-associated HCM Patients in Third Quarter 2023 Dosing Commenced in Multiple-Ascending Dose Stage of First-In-Human Clinical Trial of TN-301; Data Anticipated in Second Half 2023 2022 Year End Cash and Investm

March 8, 2023 EX-10

Outside Director Compensation Policy.

Exhibit 10.10 TENAYA THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY (as most recently amended and restated December 5, 2022 (the “Restatement Date”)) Tenaya Therapeutics, Inc. (the “Company”) believes that the granting of equity and cash compensation to members of the Company’s Board of Directors (the “Board,” and members of the Board, “Directors”) represents an effective tool to attract,

March 8, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROMTO Commission File Number 001-40656 TENAYA THERAPEUT

March 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 8, 2023 Tenaya Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 8, 2023 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

March 8, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Tenaya Therapeutics, Inc.

February 21, 2023 SC 13D/A

TNYA / Tenaya Therapeutics Inc / COLUMN GROUP III, LP - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* TENAYA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 87990A106 (CUSIP Number) James Evangelista The Column Group 1 Letterman Drive, Building D, Suite DM-900 San Francisco, CA 94129 (415) 865-2

February 14, 2023 SC 13G/A

TNYA / Tenaya Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm236221d32sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 87990A106 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statem

December 7, 2022 EX-99.1

Tenaya Therapeutics Appoints Amy Burroughs to Board of Directors

Exhibit 99.1 Tenaya Therapeutics Appoints Amy Burroughs to Board of Directors SOUTH SAN FRANCISCO, Calif., ? December 7, 2022 ? Tenaya Therapeutics, Inc. (Nasdaq: TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today announced the appointment of Amy Burroughs to its Boa

December 7, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 5, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commiss

December 7, 2022 SC 13D/A

TNYA / Tenaya Therapeutics, Inc. / Casdin Capital, LLC Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.

December 1, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13D is filed on behalf of each of the undersigned, and any amendments thereto executed by the undersigned shall be filed on behalf of each of the undersigned without the necessity of filing any additional joint filing agreement.

December 1, 2022 SC 13D

TNYA / Tenaya Therapeutics, Inc. / COLUMN GROUP III, LP - SC 13D Activist Investment

SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.)* TENAYA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 87990A106 (CUSIP Number) James Evangelista The Column Group 1 Letterman Drive, Building D, Suite DM-900 San Francisco, CA 94129 (415) 865-2050

November 28, 2022 SC 13D/A

TNYA / Tenaya Therapeutics, Inc. / Casdin Capital, LLC Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.

November 17, 2022 EX-99.1

Tenaya Therapeutics Announces Pricing of Public Offering

Exhibit 99.1 Tenaya Therapeutics Announces Pricing of Public Offering South San Francisco, Calif. ? November 17, 2022 ? Tenaya Therapeutics, Inc. (Nasdaq: TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today announced the pricing of its underwritten public offering of

November 17, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 16, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

November 17, 2022 EX-1.1

Underwriting Agreement, dated as of November 16, 2022, among Tenaya Therapeutics, Inc. and the Representatives.

EX-1.1 2 d383621dex11.htm EX-1.1 Exhibit 1.1 UNDERWRITING AGREEMENT 22,613,307 SHARES OF COMMON STOCK, $0.0001 PAR VALUE PER SHARE PRE-FUNDED WARRANTS TO PURCHASE 6,236,693 SHARES OF COMMON STOCK TENAYA THERAPEUTICS, INC. November 16, 2022 November 16, 2022 Morgan Stanley & Co. LLC Piper Sandler & Co. As Representatives of the several Underwriters named in Schedule I hereto c/o Morgan Stanley & Co

November 17, 2022 424B5

22,613,307 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 6,236,693 SHARES OF COMMON STOCK

424B5 1 d417969d424b5.htm 424B5 Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-266741 PROSPECTUS SUPPLEMENT (To prospectus dated August 17, 2022) 22,613,307 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 6,236,693 SHARES OF COMMON STOCK We are offering 22,613,307 shares of our common stock and, in lieu of common stock to certain investors that so choose, pre-funded

November 17, 2022 EX-4.1

Form of Pre-Funded Warrant.

Exhibit 4.1 TENAYA THERAPEUTICS, INC. FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK Number of Shares: [ ] (subject to adjustment) Warrant No. Original Issue Date: [ ], 2022 Tenaya Therapeutics, Inc., a Delaware corporation (the ?Company?), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its registered assigns (t

November 16, 2022 424B5

$75,000,000 COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE SHARES OF COMMON STOCK

424B5 Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-266741 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to

November 10, 2022 EX-99.1

Tenaya Therapeutics Reports Third Quarter 2022 Financial Results and Provides Business Update Extends Cash Runway to Mid-2024 Commenced Dosing in Phase 1 Clinical Trial of TN-301; Data Expected in 2023 Plans to Submit TN-201 IND by Year End

Exhibit 99.1 Tenaya Therapeutics Reports Third Quarter 2022 Financial Results and Provides Business Update Extends Cash Runway to Mid-2024 Commenced Dosing in Phase 1 Clinical Trial of TN-301; Data Expected in 2023 Plans to Submit TN-201 IND by Year End South San Francisco, Calif. ? November 10, 2022?Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a clinical-stage biotechnology company with a mission to

November 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

November 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

August 17, 2022 424B5

Up to $75,000,000 COMMON STOCK

Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-266741 PROSPECTUS SUPPLEMENT (To prospectus dated August 17, 2022) Up to $75,000,000 COMMON STOCK We have entered into a sales agreement with SVB Securities LLC (SVB Securities), relating to shares of our common stock, par value $0.0001 per share, offered by this prospectus supplement and the accompanying prospectus. In accord

August 15, 2022 CORRESP

August 15, 2022

August 15, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, DC 20549-3720 Attention: Joshua Gorsky Re: Tenaya Therapeutics, Inc. Registration Statement on Form S-3 Filed August 10, 2022 File No. 333-266741 Acceleration Request Requested Date: August 17, 2022 Requested Time: 4:00 P.M. Eastern Time, or as so

August 10, 2022 EX-1.1

Sales Agreement, dated as of August 10, 2022, between Tenaya Therapeutics, Inc. and SVB Securities LLC.

Exhibit 1.1 TENAYA THERAPEUTICS, INC. Shares of Common Stock ($0.0001 par value per share) SALES AGREEMENT August 10, 2022 SVB SECURITIES LLC 1301 Avenue of the Americas, 12th Floor New York, New York 10019 Ladies and Gentlemen: Tenaya Therapeutics, Inc., a Delaware corporation (the ?Company?), confirms its agreement (this ?Agreement?) with SVB Securities LLC (the ?Agent?), as follows: 1. Issuance

August 10, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-3 (Form Type) TENAYA THERAPEUTICS, INC.

August 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissi

August 10, 2022 S-3

As filed with the Securities and Exchange Commission on August 10, 2022

Table of Contents As filed with the Securities and Exchange Commission on August 10, 2022 Registration No.

August 10, 2022 EX-4.5

Form of Indenture

Exhibit 4.5 TENAYA THERAPEUTICS, INC. INDENTURE Dated as of , 20 [ ] Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1 Definitions 1 Section 1.2 Other Definitions 4 Section 1.3 Incorporation by Reference of Trust Indenture Act 5 Section 1.4 Rules of Construction 5 ARTICLE II THE SECURITIES 5 Section 2.1 Issuable in Series 5 Section 2.2 Establishment

August 10, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissi

August 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

August 10, 2022 EX-1.2

Sales Agreement, dated August 10, 2022, by and between Tenaya Therapeutics, Inc. and SVB Securities LLC

Exhibit 1.2 TENAYA THERAPEUTICS, INC. Shares of Common Stock ($0.0001 par value per share) SALES AGREEMENT August 10, 2022 SVB SECURITIES LLC 1301 Avenue of the Americas, 12th Floor New York, New York 10019 Ladies and Gentlemen: Tenaya Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with SVB Securities LLC (the “Agent”), as follows: 1. Issuance

August 10, 2022 EX-99.1

+ Tenaya Therapeutics Reports Second Quarter 2022 Financial Results and Provides Business Update Received State Licensing to Enable cGMP Manufacturing of Drug Product TN-201 and TN-301 IND Submissions on Track for Second Half 2022 Presented Preclinic

Exhibit 99.1 + Tenaya Therapeutics Reports Second Quarter 2022 Financial Results and Provides Business Update Received State Licensing to Enable cGMP Manufacturing of Drug Product TN-201 and TN-301 IND Submissions on Track for Second Half 2022 Presented Preclinical Data for Multiple Pipeline Programs and Capsid Engineering Efforts South San Francisco, Calif. – Aug. 10, 2022—Tenaya Therapeutics, In

June 10, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

May 11, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commission

May 11, 2022 EX-99.1

Tenaya Therapeutics Reports First Quarter 2022 Financial Results and Provides Business Update TN-201 Received Orphan Medicinal Product Designation from the European Commission Preclinical TN-401 Data Presented at Heart Rhythm 2022

Exhibit 99.1 Tenaya Therapeutics Reports First Quarter 2022 Financial Results and Provides Business Update TN-201 Received Orphan Medicinal Product Designation from the European Commission Preclinical TN-401 Data Presented at Heart Rhythm 2022 South San Francisco, Calif. ? May 11, 2022?Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a biotechnology company with a mission to discover, develop and deliver

May 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

April 28, 2022 DEF 14A

Definitive Proxy Statement

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defi

April 28, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

March 23, 2022 EX-10.2

2021 Equity Incentive Plan and forms of agreements thereunder.

Exhibit 10.2 TENAYA THERAPEUTICS, INC. 2021 EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are: ? to attract and retain the best available personnel for positions of substantial responsibility, ? to provide additional incentive to Employees, Directors and Consultants, and ? to promote the success of the Company?s business. The Plan permits the grant of Incentive Stock Opt

March 23, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Tenaya Therapeutics, Inc.

March 23, 2022 EX-4.3

Exhibit 4.3

Exhibit 4.3 Description of Securities General Tenaya Therapeutics, Inc. (?we,? ?our,? or ?us?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?): our common stock $0.0001 par value per share. The following descriptions of our capital stock and certain provisions of our amended and restated certificate of incorporation an

March 23, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 23, 2022 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissio

March 23, 2022 S-8

As filed with the Securities and Exchange Commission on March 23, 2022 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 TENAYA THERAPEUTICS, INC. (Exact name of registr

As filed with the Securities and Exchange Commission on March 23, 2022 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 23, 2022 EX-99.1

Tenaya Therapeutics Reports Fourth Quarter and Year-End 2021 Financial Results and Provides Business Updates Strengthened Leadership Team with the Additions of Sunita Sethi as Senior Vice President of Regulatory Affairs and Naymisha Patel as Senior V

Exhibit 99.1 Tenaya Therapeutics Reports Fourth Quarter and Year-End 2021 Financial Results and Provides Business Updates Strengthened Leadership Team with the Additions of Sunita Sethi as Senior Vice President of Regulatory Affairs and Naymisha Patel as Senior Vice President of Quality South San Francisco, Calif. ? March 23, 2022?Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a biotechnology company w

March 23, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROMTO Commission File Number 001-40656 TENAYA THERAPEUT

February 14, 2022 SC 13G

TNYA / Tenaya Therapeutics, Inc. / Walton Thomas Layton - SCHEDULE 13G, AMENDMENT 1 Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 Under the Securities Exchange Act of 1934 (AMENDMENT NO. 1) Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securi

February 14, 2022 SC 13G

VGG8959N1069 / Tottenham Acquisition I Limited / Walton Thomas Layton - SCHEDULE 13G, AMENDMENT 1 Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 Under the Securities Exchange Act of 1934 (AMENDMENT NO. 1) Clene Inc. (Name of Issuer) Common Stock, $.0001 par value (Title of Class of Securities) G8959N130

February 14, 2022 SC 13G

TNYA / Tenaya Therapeutics, Inc. / RTW INVESTMENTS, LP - TENAYA THERAPEUTICS, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 87990A106 (CUSIP Number) December 31, 2021 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursua

February 14, 2022 SC 13G

TNYA / Tenaya Therapeutics, Inc. / Ugwumba Chidozie - SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (AMENDMENT NO. ) Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 87990A106 (CUSIP Number) December 31,

February 11, 2022 EX-99.1

JOINT FILING AGREEMENT

JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned, and any amendments thereto executed by the undersigned shall be filed on behalf of each of the undersigned without the necessity of filing any additional joint filing agreement.

February 11, 2022 SC 13G

TNYA / Tenaya Therapeutics, Inc. / COLUMN GROUP III, LP - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* TENAYA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 87990A106 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate t

December 22, 2021 EX-99.1

Tenaya Therapeutics appoints Karah Parschauer, J.D., to its Board of Directors and Joanna Auch as Senior Vice President of People and Culture

Exhibit 99.1 Tenaya Therapeutics appoints Karah Parschauer, J.D., to its Board of Directors and Joanna Auch as Senior Vice President of People and Culture SOUTH SAN FRANCISCO, Calif., ? December 22, 2021 ? Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a biotechnology company with a mission to discover, develop and deliver curative therapies that address the underlying causes of heart disease, today an

December 22, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2021 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

November 22, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 17, 2021 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

November 22, 2021 EX-99.1

Tenaya Therapeutics Announces the Addition of Dr. June Lee to its Board of Directors

Exhibit 99.1 Tenaya Therapeutics Announces the Addition of Dr. June Lee to its Board of Directors SOUTH SAN FRANCISCO, Calif.?(BUSINESS WIRE)?Nov. 22, 2021? Tenaya Therapeutics, Inc. (NASDAQ:TNYA), a biotechnology company with a mission to discover, develop and deliver curative therapies that address the underlying causes of heart disease, today announced changes to its Board of Directors includin

November 10, 2021 EX-99.1

Tenaya Therapeutics Reports Third Quarter 2021 Financial Results and Provides Business Updates

Exhibit 99.1 Tenaya Therapeutics Reports Third Quarter 2021 Financial Results and Provides Business Updates - Initiated global natural history study for pediatric patients with MYBPC3 mutation to support clinical development of TN-201 gene therapy - Presented preclinical data supporting both TN-201 and PKP2 gene therapy programs at the European Society of Gene and Cell Therapy conference demonstra

November 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2021 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

November 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

September 8, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 8, 2021 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commis

September 8, 2021 EX-99.1

TENAYA THERAPEUTICS, INC. Condensed Statements of Operations and Comprehensive Loss (In thousands, except share and per share data) Three Months Ended June 30, Six Months Ended June 30, 2021 2020 2021 2020 Operating expenses: Research and development

Exhibit 99.1 Tenaya Therapeutics Reports Second Quarter 2021 Financial Results and Provides Business Updates ? TN-201 MYBPC3 gene therapy product candidate for the leading genetic cause of hypertrophic cardiomyopathy granted Orphan Drug Designation (ODD) by the U.S. Food and Drug Administration (FDA) ? Expanded leadership team appointing Leone Patterson as Chief Financial and Business Officer and

September 8, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40656 TENAYA THERAPEUTICS, INC.

August 9, 2021 SC 13D

TNYA / Tenaya Therapeutics, Inc. / Casdin Capital, LLC Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.

August 9, 2021 SC 13G

TNYA / Tenaya Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 87990A106 (CUSIP Number) July 30, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the r

August 9, 2021 SC 13G

TNYA / Tenaya Therapeutics, Inc. / Walton Thomas Layton - SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (AMENDMENT NO. ) Tenaya Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 87990A106 (CUSIP Number) August 3, 2021 (Date of Ev

August 3, 2021 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2021 Tenaya Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40656 81-3789973 (State or other jurisdiction of incorporation) (Commissio

August 3, 2021 EX-3.2

Amended and Restated Bylaws of Tenaya Therapeutics, Inc.

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF TENAYA THERAPEUTICS, INC. (initially adopted on August 18, 2016) (as amended and restated on August 3, 2021) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 ADVANCE NOTICE PROCEDURES 2 2.5 NOTICE

August 3, 2021 EX-99.1

Tenaya Therapeutics Announces Closing of Upsized Initial Public Offering and Exercise in Full of the Underwriters’ Option to Purchase Additional Shares

Exhibit 99.1 Tenaya Therapeutics Announces Closing of Upsized Initial Public Offering and Exercise in Full of the Underwriters? Option to Purchase Additional Shares SOUTH SAN FRANCISCO, Calif., August 3, 2021 ? Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a biotechnology company with a mission to discover, develop and deliver curative therapies that address the underlying causes of heart disease, ann

August 3, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of Tenaya Therapeutics, Inc.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TENAYA THERAPEUTICS, INC. a Delaware corporation Tenaya Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the ?Company?), does hereby certify as follows: A. The original Certificate of Incorporation of the Company was filed with the Secretary of State of the State of Delaware on August

July 30, 2021 424B4

12,000,000 Shares Common Stock

Table of Contents Filed pursuant to 424(b)(4) Registration Nos. 333-257820 and 333-258285 PROSPECTUS 12,000,000 Shares Common Stock Tenaya Therapeutics, Inc. is offering 12,000,000 shares of our common stock. This is the initial public offering, and no public market currently exists for our shares of common stock. The initial public offering price is $15.00 per share. Our common stock has been app

July 30, 2021 S-8

As filed with the Securities and Exchange Commission on July 30, 2021

As filed with the Securities and Exchange Commission on July 30, 2021 Registration No.

July 29, 2021 S-1MEF

As filed with the Securities and Exchange Commission on July 29, 2021.

As filed with the Securities and Exchange Commission on July 29, 2021. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 TENAYA THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) Delaware 2836 82-3789973 (State or other jurisdiction of incorporation or organization) (

July 27, 2021 CORRESP

[Signature page immediately follows]

CORRESP 1 filename1.htm Morgan Stanley & Co. LLC 1585 Broadway New York, New York 10036 Cowen and Company, LLC 599 Lexington Avenue New York, New York 10022 Piper Sandler & Co. 800 Nicollet Mall, Suite 800 Minneapolis, MN 55402 July 27, 2021 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Tracey Ho

July 27, 2021 CORRESP

July 27, 2021

CORRESP 1 filename1.htm July 27, 2021 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Tracey Houser Brian Cascio Tom Kluck Suzanne Hayes Re: Tenaya Therapeutics, Inc. Registration Statement on Form S-1 (File No. 333-257820) Acceleration Request Requested Date: Thursday, July 29, 2021 Requ

July 26, 2021 EX-1.1

Form of Underwriting Agreement.

Exhibit 1.1 UNDERWRITING AGREEMENT [•] Shares TENAYA THERAPEUTICS, INC. COMMON STOCK, $0.0001 PAR VALUE PER SHARE [•], 2021 [•], 2021 Morgan Stanley & Co. LLC Cowen and Company, LLC Piper Sandler & Co. As Representatives of the several Underwriters named in Schedule I hereto c/o Morgan Stanley & Co. LLC 1585 Broadway New York, New York 10036 c/o Cowen and Company, LLC 599 Lexington Avenue New York

July 26, 2021 EX-4.2

Specimen common stock certificate of the Registrant.

Exhibit 4.2 Exhibit 4.2 ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK COMMON STOCK PAR VALUE $0.0001 Certificate Shares Number * * 000000 ****************** * * * 000000 ***************** ZQ00000000 **** 000000 **************** TENAYA THERAPEUTICS, INC. ***** 000000 *************** ****** 000000 ************** INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE THIS CERTIFIES T

July 26, 2021 EX-10.14

Outside Director Compensation Policy.

Exhibit 10.14 TENAYA THERAPEUTICS, INC. OUTSIDE DIRECTOR COMPENSATION POLICY Tenaya Therapeutics, Inc. (the “Company”) believes that the granting of equity and cash compensation to members of the Company’s Board of Directors (the “Board,” and members of the Board, “Directors”) represents an effective tool to attract, retain and reward Directors who are not employees of the Company (“Outside Direct

July 26, 2021 S-1/A

As filed with the Securities and Exchange Commission on July 26, 2021.

S-1/A 1 d175698ds1a.htm S-1/A Table of Contents As filed with the Securities and Exchange Commission on July 26, 2021. Registration No. 333-257820 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-1 REGISTRATION STATEMENT Under the Securities Act of 1933 TENAYA THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) Delaware (State

July 26, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant, as amended, as currently in effect.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TENAYA THERAPEUTICS, INC. Tenaya Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the ?Corporation?), certifies that: 1. The name of the Corporation is Tenaya Therapeutics, Inc. The Corporation?s original Certificate of Incorporation was filed with the Secretary of State of the State o

July 26, 2021 CORRESP

July 26, 2021

CORRESP 1 filename1.htm 650 Page Mill Road Palo Alto, CA 94304-1050 650.493.9300 650.493.6811 www.wsgr.com July 26, 2021 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Tracey Houser Brian Cascio Tom Kluck Suzanne Hayes Re: Tenaya Therapeutics, Inc. Registration Statement on Form S-1 File

July 26, 2021 EX-10.3

2021 Equity Incentive Plan and forms of agreements thereunder.

Exhibit 10.3 TENAYA THERAPEUTICS, INC. 2021 EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are: ? to attract and retain the best available personnel for positions of substantial responsibility, ? to provide additional incentive to Employees, Directors and Consultants, and ? to promote the success of the Company?s business. The Plan permits the grant of Incentive Stock Opt

July 26, 2021 EX-10.4

2021 Employee Stock Purchase Plan and forms of agreements thereunder.

Exhibit 10.4 TENAYA THERAPEUTICS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN 1. Purpose. The purpose of the Plan is to provide employees of the Company and its Designated Companies with an opportunity to purchase Common Stock through accumulated Contributions. The Company intends for the Plan to have two components: a component that is intended to qualify as an ?employee stock purchase plan? under Cod

July 23, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 TENAYA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 81-3789973 (State of incorporation or organization) (I.R.S. Employer Identification No.) 171 Oyster Point B

July 9, 2021 EX-3.2

Form of Amended and Restated Certificate of Incorporation of the Registrant, to be in effect upon the completion of this offering.

Exhibit 3.2 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TENAYA THERAPEUTICS, INC. a Delaware corporation Tenaya Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Company”), does hereby certify as follows: A. The original Certificate of Incorporation of the Company was filed with the Secretary of State of the State of Delaware on August

July 9, 2021 EX-10.10

Lease between HCP Oyster Point III LLC and the Registrant dated as of September 6, 2016.

Exhibit 10.10 THE COVE AT OYSTER POINT LEASE This Lease (the ?Lease?), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the ?Summary?), below, is made by and between HCP OYSTER POINT III LLC, a Delaware limited liability company (?Landlord?), and THE COLUMN GROUP, LLC, a Delaware limited liability company (?Tenant?). SUMMARY OF BASIC LEASE INFORMATION TERMS OF

July 9, 2021 EX-3.4

Form of Amended and Restated Bylaws of the Registrant, to be in effect upon the completion of this offering.

Exhibit 3.4 AMENDED AND RESTATED BYLAWS OF TENAYA THERAPEUTICS, INC. (initially adopted on August 18, 2016) (as amended and restated on , 2021) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 ADVANCE NOTICE PROCEDURES 2 2.5 NOTICE OF STOC

July 9, 2021 EX-4.1

Amended and Restated Investors’ Rights Agreement by and among the Registrant and certain of its stockholders, dated December 17, 2020.

Exhibit 4.1 TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT December 17, 2020 TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT This Amended and Restated Investors’ Rights Agreement (this “Agreement”) is dated as of December 17, 2020, and is between Tenaya Therapeutics, Inc., a Delaware corporation (the “Company”), and the persons and entities li

July 9, 2021 S-1

As filed with the Securities and Exchange Commission on July 9, 2021.

Table of Contents As filed with the Securities and Exchange Commission on July 9, 2021.

July 9, 2021 EX-3.3

Bylaws of the Registrant, as currently in effect.

Exhibit 3.3 BYLAWS OF TENAYA THERAPEUTICS, INC. Adopted August 18, 2016 TABLE OF CONTENTS Page ARTICLE I — MEETINGS OF STOCKHOLDERS 1 1.1 Place of Meetings 1 1.2 Annual Meeting 1 1.3 Special Meeting 1 1.4 Notice of Stockholders’ Meetings 1 1.5 Quorum 2 1.6 Adjourned Meeting; Notice 2 1.7 Conduct of Business 2 1.8 Voting 2 1.9 Stockholder Action by Written Consent Without a Meeting 3 1.10 Record Da

July 9, 2021 EX-10.5

Employment Letter between the Registrant and Faraz Ali, M.B.A.

Exhibit 10.5 June 28, 2021 Faraz Ali c/o Tenaya Therapeutics, Inc. Re: Confirmatory Employment Letter Dear Faraz: This confirmatory employment letter agreement (the ?Agreement?) is entered into between you and Tenaya Therapeutics, Inc. (the ?Company? or ?we?), effective as of the effective date of the Company?s registration statement relating to the Company?s initial public offering (the ?Effectiv

July 9, 2021 EX-10.2

Amended and Restated 2016 Equity Incentive Plan and forms of agreement thereunder.

Exhibit 10.2 TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED 2016 EQUITY INCENTIVE PLAN ORIGINAL PLAN ADOPTED BY THE BOARD OF DIRECTORS: OCTOBER 2, 2016 ORIGINAL PLAN APPROVED BY THE STOCKHOLDERS: OCTOBER 12, 2016 AMENDED AND RESTATED PLAN ADOPTED BY THE BOARD OF DIRECTORS: AUGUST 28, 2019 AMENDED AND RESTATED PLAN ADOPTED BY THE STOCKHOLDERS: AUGUST 28, 2019 AMENDED AND RESTATED PLAN ADOPTED BY TH

July 9, 2021 EX-10.12

Executive Change in Control and Severance Plan.

Exhibit 10.12 TENAYA THERAPEUTICS, INC. EXECUTIVE CHANGE IN CONTROL AND SEVERANCE PLAN AND SUMMARY PLAN DESCRIPTION 1. Introduction. The purpose of this Tenaya Therapeutics, Inc. Executive Change in Control and Severance Plan (the “Plan”) is to provide assurances of specified benefits to certain employees of the Company whose employment could be being involuntarily terminated other than for death,

July 9, 2021 EX-10.11

Lease between Terreno Park Union City LLC and the Registrant dated as of February 12, 2021.

Exhibit 10.11 INDUSTRIAL LEASE ? MULTI-TENANT by and between TERRENO PARK UNION CITY LLC ?LANDLORD? and TENAYA THERAPEUTICS, INC. ?TENANT? Dated: February 12, 2021 TERRENO REALTY CORPORATION INDUSTRIAL LEASE 1. Basic Provisions (?Basic Provisions?). 1.1 Parties: This Lease (?Lease?) dated February 12, 2021, is made by and between Terreno Park Union City LLC, a Delaware limited liability company (?

July 9, 2021 EX-10.1

Form of Indemnification Agreement between the Registrant and each of its directors and executive officers.

Exhibit 10.1 TENAYA THERAPEUTICS, INC. INDEMNIFICATION AGREEMENT This Indemnification Agreement (this “Agreement”) is dated as of [insert date], and is between Tenaya Therapeutics, Inc., a Delaware corporation (the “Company”), and [insert name of indemnitee] (“Indemnitee”). RECITALS A. Indemnitee’s service to the Company substantially benefits the Company. B. Individuals are reluctant to serve as

July 9, 2021 EX-10.13

Executive Incentive Compensation Plan.

Exhibit 10.13 TENAYA THERAPEUTICS, INC. EXECUTIVE INCENTIVE COMPENSATION PLAN 1. Purposes of the Plan. The Plan is intended to increase stockholder value and the success of the Company by motivating Employees to (a) perform to the best of their abilities and (b) achieve the Company’s objectives. 2. Definitions. 2.1 “Actual Award” means as to any Performance Period, the actual award (if any) payabl

July 9, 2021 EX-10.7

Employment Letter between the Registrant and Leone D. Patterson, M.B.A.

Exhibit 10.7 Leone Patterson June 18, 2021 Dear Leone: On behalf of Tenaya Therapeutics, Inc. (“we” or the “Company”), I am pleased to invite you to join the Company on the terms and conditions set forth in this letter agreement (the “Agreement”), effective as of the date on which you commence employment with the Company (the “Effective Date”). We look forward to the possibility of your joining ou

July 9, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant, as currently in effect.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TENAYA THERAPEUTICS, INC. Tenaya Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the ?Corporation?), certifies that: 1. The name of the Corporation is Tenaya Therapeutics, Inc. The Corporation?s original Certificate of Incorporation was filed with the Secretary of State of the State o

July 9, 2021 EX-10.8

Employment Letter between the Registrant and Whittemore (Whit) Tingley, M.D., Ph.D.

Exhibit 10.8 June 25, 2021 Whittemore Tingley c/o Tenaya Therapeutics, Inc. Re: Confirmatory Employment Letter Dear Whit: This confirmatory employment letter agreement (the “Agreement”) is entered into between you and Tenaya Therapeutics, Inc. (the “Company” or “we”), effective as of the effective date of the Company’s registration statement relating to the Company’s initial public offering (the “

July 9, 2021 CORRESP

July 9, 2021

650 Page Mill Road Palo Alto, CA 94304-1050 650.493.9300 650.493.6811 www.wsgr.com July 9, 2021 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Brian Cascio Tracey Houser Tom Kluck Suzanne Hayes Re: Tenaya Therapeutics, Inc. Amended Draft Registration Statement on Form S-1 Submitted June

July 9, 2021 EX-10.6

Employment Letter between the Registrant and Timothy Hoey, Ph.D

Exhibit 10.6 June 25, 2021 Timothy Hoey c/o Tenaya Therapeutics, Inc. Re: Confirmatory Employment Letter Dear Tim: This confirmatory employment letter agreement (the “Agreement”) is entered into between you and Tenaya Therapeutics, Inc. (the “Company” or “we”), effective as of the effective date of the Company’s registration statement relating to the Company’s initial public offering (the “Effecti

July 9, 2021 EX-10.9

License Agreement between the Registrant and the Board of Regents of the University of Texas System, dated as of January 10, 2020.

Exhibit 10.9 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED. [***] INDICATES THAT INFORMATION HAS BEEN REDACTED. LICENSE AGREEMENT This License Agreement (this “Agreement”) is dated as of January 10, 2020 (the “Effective Date”) by and between The Board of Regents (“Board”)

June 16, 2021 EX-10.2

TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED 2016 EQUITY INCENTIVE PLAN ORIGINAL PLAN ADOPTED BY THE BOARD OF DIRECTORS: OCTOBER 2, 2016 ORIGINAL PLAN APPROVED BY THE STOCKHOLDERS: OCTOBER 12, 2016 AMENDED AND RESTATED PLAN ADOPTED BY THE BOARD OF

EX-10.2 2 filename2.htm Exhibit 10.2 TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED 2016 EQUITY INCENTIVE PLAN ORIGINAL PLAN ADOPTED BY THE BOARD OF DIRECTORS: OCTOBER 2, 2016 ORIGINAL PLAN APPROVED BY THE STOCKHOLDERS: OCTOBER 12, 2016 AMENDED AND RESTATED PLAN ADOPTED BY THE BOARD OF DIRECTORS: AUGUST 28, 2019 AMENDED AND RESTATED PLAN ADOPTED BY THE STOCKHOLDERS: AUGUST 28, 2019 AMENDED AND RES

June 16, 2021 EX-10.10

THE COVE AT OYSTER POINT

Exhibit 10.10 THE COVE AT OYSTER POINT LEASE This Lease (the ?Lease?), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the ?Summary?), below, is made by and between HCP OYSTER POINT III LLC, a Delaware limited liability company (?Landlord?), and THE COLUMN GROUP, LLC, a Delaware limited liability company (?Tenant?). SUMMARY OF BASIC LEASE INFORMATION TERMS OF

June 16, 2021 DRS/A

Amendment No. 1 to Draft Registration Statement, as confidentially submitted to the Securities and Exchange Commission on June 15, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all

Table of Contents Amendment No. 1 to Draft Registration Statement, as confidentially submitted to the Securities and Exchange Commission on June 15, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains strictly confidential. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington

June 16, 2021 EX-10.11

INDUSTRIAL LEASE – MULTI-TENANT by and between TERRENO PARK UNION CITY LLC TENAYA THERAPEUTICS, INC. Dated: February 12, 2021

EX-10.11 4 filename4.htm Exhibit 10.11 INDUSTRIAL LEASE – MULTI-TENANT by and between TERRENO PARK UNION CITY LLC “LANDLORD” and TENAYA THERAPEUTICS, INC. “TENANT” Dated: February 12, 2021 TERRENO REALTY CORPORATION INDUSTRIAL LEASE 1. Basic Provisions (“Basic Provisions”). 1.1 Parties: This Lease (“Lease”) dated February 12, 2021, is made by and between Terreno Park Union City LLC, a Delaware lim

June 15, 2021 DRSLTR

June 15, 2021

650 Page Mill Road Palo Alto, CA 94304-1050 650.493.9300 650.493.6811 www.wsgr.com June 15, 2021 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Brian Cascio Tracey Houser Tom Kluck Suzanne Hayes Re: Tenaya Therapeutics, Inc. Draft Registration Statement on Form S-1 Submitted May 7, 2021

May 7, 2021 DRS

As confidentially submitted to the Securities and Exchange Commission on May 7, 2021 This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains strictly confidential.

Table of Contents As confidentially submitted to the Securities and Exchange Commission on May 7, 2021 This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains strictly confidential.

May 7, 2021 EX-3.3

BYLAWS OF TENAYA THERAPEUTICS, INC. Adopted August 18, 2016

EX-3.3 3 filename3.htm Exhibit 3.3 BYLAWS OF TENAYA THERAPEUTICS, INC. Adopted August 18, 2016 TABLE OF CONTENTS Page ARTICLE I — MEETINGS OF STOCKHOLDERS 1 1.1 Place of Meetings 1 1.2 Annual Meeting 1 1.3 Special Meeting 1 1.4 Notice of Stockholders’ Meetings 1 1.5 Quorum 2 1.6 Adjourned Meeting; Notice 2 1.7 Conduct of Business 2 1.8 Voting 2 1.9 Stockholder Action by Written Consent Without a M

May 7, 2021 EX-4.1

TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT December 17, 2020

EX-4.1 4 filename4.htm Exhibit 4.1 TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT December 17, 2020 TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT This Amended and Restated Investors’ Rights Agreement (this “Agreement”) is dated as of December 17, 2020, and is between Tenaya Therapeutics, Inc., a Delaware corporation (the “Company”), and the

May 7, 2021 EX-10.9

LICENSE AGREEMENT

EX-10.9 5 filename5.htm Exhibit 10.9 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED. [***] INDICATES THAT INFORMATION HAS BEEN REDACTED. LICENSE AGREEMENT This License Agreement (this “Agreement”) is dated as of January 10, 2020 (the “Effective Date”) by and between The Bo

May 7, 2021 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TENAYA THERAPEUTICS, INC.

EX-3.1 2 filename2.htm Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TENAYA THERAPEUTICS, INC. Tenaya Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), certifies that: 1. The name of the Corporation is Tenaya Therapeutics, Inc. The Corporation’s original Certificate of Incorporation was filed with the Secretary

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