TYRA / Tyra Biosciences, Inc. - Pemfailan SEC, Laporan Tahunan, Penyata Proksi

Tyra Biosciences, Inc.
US ˙ NasdaqGS ˙ US90240B1061

Statistik Asas
CIK 1863127
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Tyra Biosciences, Inc.
SEC Filings (Chronological Order)
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August 22, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 21, 2025 Tyra Biosciences,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 21, 2025 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

August 14, 2025 EX-10.1

Non-Employee Director Compensation Program, amended and restated effective May 29, 2025

Exhibit 10.1 Tyra Biosciences, Inc. Non-Employee Director Compensation Program (Amended and Restated Effective May 29, 2025) Non-employee members of the board of directors (the “Board”) of Tyra Biosciences, Inc. (the “Company”) shall receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”). The cash and equity compensation described in t

August 14, 2025 EX-99.1

Tyra Biosciences Reports Second Quarter 2025 Financial Results and Highlights - Dosed first patient in SURF302 for intermediate risk non-muscle invasive bladder cancer (IR NMIBC) - - Cash, cash equivalents, and marketable securities of $296.3 million

Exhibit 99.1 Tyra Biosciences Reports Second Quarter 2025 Financial Results and Highlights - Dosed first patient in SURF302 for intermediate risk non-muscle invasive bladder cancer (IR NMIBC) - - Cash, cash equivalents, and marketable securities of $296.3 million at Q2 2025; runway through at least 2027 - CARLSBAD, Calif., August 14, 2025 – Tyra Biosciences, Inc. (Nasdaq: TYRA), a clinical-stage b

August 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

August 14, 2025 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

June 30, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 30, 2025 Tyra Biosciences, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 30, 2025 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 29, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2025 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 14, 2025 CORRESP

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008 May 14, 2025 VIA EDGAR Jason Drory Office of Life Sciences Division of Corporation Finance U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Tyra Biosciences, Inc. Registration Statement on Form S-3 File No. 333-287086 To the addressee set forth above: Pursuant to Rule 461 of Regulation C of the General

May 8, 2025 10-Q

Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

May 8, 2025 EX-4.6

Form of Indenture.

Exhibit 4.6 TYRA BIOSCIENCES, INC. INDENTURE Dated as of , 20 [] Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 4 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 5 Section 2.1. Issuable in Series 5 Section 2.2. Establishm

May 8, 2025 EX-1.2

Sales Agreement, dated May 8, 2025, by and between the Registrant and TD Securities (USA) LLC

Exhibit 1.2 TYRA BIOSCIENCES, INC. $150,000,000 COMMON STOCK SALES AGREEMENT May 8, 2025 TD Securities (USA) LLC 1 Vanderbilt Avenue New York, New York 10017 Ladies and Gentlemen: Tyra Biosciences, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with TD Securities (USA) LLC (“TD Cowen”), as follows, it being understood that all references in this Agreement t

May 8, 2025 S-3

As filed with the Securities and Exchange Commission on May 8, 2025

Table of Contents As filed with the Securities and Exchange Commission on May 8, 2025 Registration No.

May 8, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 08, 2025 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 8, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 CALCULATION OF FILING FEE TABLE Registration Statement on Form S-3 (Form Type) Tyra Biosciences, Inc.

May 8, 2025 EX-99.1

Tyra Biosciences Reports First Quarter 2025 Financial Results and Highlights - BEACH301 study of TYRA-300 for Pediatric Achondroplasia (ACH) Open for Enrollment - - Initiated patient dosing in SURF431 study of TYRA-430 for hepatocellular carcinoma (H

Exhibit 99.1 Tyra Biosciences Reports First Quarter 2025 Financial Results and Highlights - BEACH301 study of TYRA-300 for Pediatric Achondroplasia (ACH) Open for Enrollment - - Initiated patient dosing in SURF431 study of TYRA-430 for hepatocellular carcinoma (HCC) - - Cash, cash equivalents, and marketable securities of $318.9 million at Q1 2025; runway through at least 2027 - CARLSBAD, Calif.,

April 18, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)

April 18, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

March 27, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40800 TYRA BIOSCIENCE

March 27, 2025 EX-99.1

Tyra Biosciences Reports Fourth Quarter and Full Year 2024 Financial Results and Highlights - Three INDs cleared by US FDA for TYRA’s proprietary precision small molecules - - TYRA-300 to be evaluated in three Phase 2 studies: SURF302 for Intermediat

Exhibit 99.1 Tyra Biosciences Reports Fourth Quarter and Full Year 2024 Financial Results and Highlights - Three INDs cleared by US FDA for TYRA’s proprietary precision small molecules - - TYRA-300 to be evaluated in three Phase 2 studies: SURF302 for Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR NMIBC), BEACH301 for pediatric achondroplasia (ACH) and SURF301 for metastatic urothelial c

March 27, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 27, 2025 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission F

March 27, 2025 EX-19.1

Insider Trading Compliance Policy and Procedures

Exhibit 19.1 Tyra Biosciences, Inc. Insider Trading Compliance Policy and Procedures Federal and state laws prohibit trading in the securities of a company while in possession of material nonpublic information and in breach of a duty of trust or confidence. These laws also prohibit anyone who is aware of material nonpublic information from providing this information to others who may trade. Violat

January 29, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 28, 2025 Tyra Biosciences

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 28, 2025 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

December 6, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / Boxer Capital Management, LLC Activist Investment

SC 13D/A 1 ff420987613da6-tyra.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (RULE 13D - 101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a) (Amendment No. 6)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106 (CU

November 19, 2024 EX-7

Stock Purchase Agreement, dated November 8, 2024, among Boxer Capital, LLC and RA Capital Healthcare Fund, LP.

EX-7 2 ff4142386ex7-tyra.htm STOCK PURCHASE AGREEMENT This STOCK PURCHASE AGREEMENT (the “Agreement”) is made as of November 8, 2024 (the “Effective Date”), by and among RA Capital Healthcare Fund, L.P. a Delaware limited partnership (the “Purchaser”), on the one hand, and Boxer Capital, LLC, a Delaware limited liability company (“Seller”), on the other hand (each a “Party”). The Seller desires to

November 19, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / Boxer Capital Management, LLC Activist Investment

SC 13D/A 1 ff414238613da5-tyra.htm UNITED STATES SECURITIES AND EXCHANedgGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (RULE 13D - 101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a) (Amendment No. 5)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106

November 14, 2024 SC 13G/A

TYRA / Tyra Biosciences, Inc. / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 2 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 sc13ga207422tyra11142024.htm AMENDMENT NO. 2 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 2)1 Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par

November 14, 2024 EX-99.A

A - Joint Filing Statement

EX-99.A 2 tm2427660d299-a.htm EXHIBIT 99.A Exhibit 99.A EXHIBIT A JOINT FILING STATEMENT We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the Common Stock of Tyra Biosciences, Inc. is filed on behalf of each of us. Dated: November 14, 2024 Nextech VI Oncology SCSp By: Nextech VI GP S.à r.l. its General Partner By: /s/ Ian Char

November 14, 2024 SC 13G/A

TYRA / Tyra Biosciences, Inc. / NEXTECH VI ONCOLOGY SCSP - SC 13G/A Passive Investment

SC 13G/A 1 tm2427660d2sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 90240B106 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement)

November 13, 2024 EX-7

Stock Purchase Agreement

EX-7 3 tm2428367d1ex7.htm EXHIBIT 7 Exhibit 7 STOCK PURCHASE AGREEMENT This STOCK PURCHASE AGREEMENT (the “Agreement”) is made as of November 8, 2024 (the “Effective Date”), by and among RA Capital Healthcare Fund, L.P. a Delaware limited partnership (the “Purchaser”), on the one hand, and Boxer Capital, LLC, a Delaware limited liability company (“Seller”), on the other hand (each a “Party”). The

November 13, 2024 EX-1

Joint Filing Agreement

EX-1 2 tm2428367d1ex1.htm EXHIBIT 1 CUSIP No. 90240B106 EXHIBIT 1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of November 13, 2024, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the “Filers”). Each of the Filers may be required to file with the United States Sec

November 13, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 90240B106 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617

November 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 07, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commissio

November 7, 2024 EX-10.2

Employment Agreement, dated September 9, 2024, between the Registrant and Douglas Warner, M.D.

Exhibit 10.2 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is effective as of September 9, 2024 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Douglas Warner, M.D. (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwise defined shall have those m

November 7, 2024 EX-10.1

Transition Agreement, dated August 3, 2024, between the Registrant and Hiroomi Tada, M.D., Ph.D.

Exhibit 10.1 TYRA BIOSCIENCES, INC. TRANSITION AGREEMENT This Transition Agreement (the “Agreement”) is entered into effective as of August 3, 2024 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Hiroomi Tada, M.D., Ph.D. (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwise defined sha

November 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

November 7, 2024 EX-99.1

Tyra Biosciences Reports Third Quarter 2024 Financial Results and Highlights - Reported positive interim clinical proof-of-concept results for TYRA-300 in mUC from SURF301 Ph1/2 study - - IND cleared for Phase 2 study of TYRA-300 in pediatric achondr

Exhibit 99.1 Tyra Biosciences Reports Third Quarter 2024 Financial Results and Highlights - Reported positive interim clinical proof-of-concept results for TYRA-300 in mUC from SURF301 Ph1/2 study - - IND cleared for Phase 2 study of TYRA-300 in pediatric achondroplasia (BEACH301) - - Strengthened leadership with appointment of Doug Warner, MD as Chief Medical Officer - - Cash, cash equivalents, a

October 28, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 28, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

October 25, 2024 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 24, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

October 25, 2024 EX-99.1

Today’s participants and agenda AGENDA Introduction Todd Interim SURF301 TYRA-300 results Doug Q&A: Perspective of a leading Urologist Gary Todd Harris, PhD Doug Warner, MD Gary Steinberg, MD CEO, TYRA CMO, TYRA Professor of Urology, Dept. of Urology

Interim clinical proof-of-concept with TYRA-300 in mUC (SURF301) October 25, 2024 Exhibit 99.

October 22, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2426636-1sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 90240B106 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 0

October 22, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / Boxer Capital Management, LLC Activist Investment

SC 13D/A 1 ff402517513da4-tyra.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (RULE 13D - 101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a) (Amendment No. 4)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106 (CU

October 18, 2024 EX-4.1

Form of Exchange Warrant

Exhibit 4.1 THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY OTHER APPLICABLE SECURITIES LAWS AND HAVE BEEN ISSUED IN RELIANCE UPON AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND SUCH OTHER SECURITIES LAWS. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE

October 18, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

October 15, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / Boxer Capital, LLC Activist Investment

SC 13D/A 1 ff399731213da-tyraboxcap.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (RULE 13D - 101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a) (Amendment No. 3)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 90240B106

October 15, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / Boxer Asset Management Inc. Activist Investment

SC 13D/A 1 ff399115613da3-tyra.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (RULE 13D - 101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a) (Amendment No. 3)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106 (CU

August 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 07, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

August 7, 2024 EX-99.1

Tyra Biosciences Reports Second Quarter 2024 Financial Results and Highlights - SURF301 Ph1 initial results and ACH IND submission expected in 2H24 - - Reported preclinical proof-of-concept with TYRA-300 in HCH, demonstrating increases in long bone l

Exhibit 99.1 Tyra Biosciences Reports Second Quarter 2024 Financial Results and Highlights - SURF301 Ph1 initial results and ACH IND submission expected in 2H24 - - Reported preclinical proof-of-concept with TYRA-300 in HCH, demonstrating increases in long bone length and binding against the HCH altered protein - -IND cleared for TYRA-430, an FGFR4/3 biased inhibitor for HCC - - Announced Chief Me

August 7, 2024 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

May 31, 2024 EX-3.1

Certificate of Amendment of Amended and Restated Certificate of Incorporation, dated May 29, 2024

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. Tyra Biosciences, Inc. (the “Corporation”), a corporation organized and existing under the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify as follows: 1. The Corporation originally filed its Certificate of Incorporation on August 2, 2018. 2. This Ce

May 31, 2024 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 9, 2024 EX-10.3

Non-Employee Director Compensation Program, amended and restated effective May 1, 2024

Exhibit 10.3 Tyra Biosciences, Inc. Non-Employee Director Compensation Program (Amended and Restated Effective May 1, 2024) Non-employee members of the board of directors (the “Board”) of Tyra Biosciences, Inc. (the “Company”) shall receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”). The cash and equity compensation described in th

May 9, 2024 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

May 9, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 09, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 9, 2024 EX-99.1

Tyra Biosciences Reports First Quarter 2024 Financial Results and Highlights - TYRA-300 on track in ACH and oncology; SURF301 Ph1 initial results and ACH IND submission expected in 2H24 - - Cash, cash equivalents, and marketable securities of $382.5

Exhibit 99.1 Tyra Biosciences Reports First Quarter 2024 Financial Results and Highlights - TYRA-300 on track in ACH and oncology; SURF301 Ph1 initial results and ACH IND submission expected in 2H24 - - Cash, cash equivalents, and marketable securities of $382.5 million at Q1 2024 - - Susan Moran, M.D., M.S.C.E. and S. Michael Rothenberg, M.D., Ph.D. appointed to TYRA Board of Directors - CARLSBAD

May 7, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 04, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 7, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 18, 2024 CORRESP

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008 April 18, 2024 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Tyra Biosciences, Inc. Registration Statement on Form S-3 File No. 333-278068 To the addressees set forth above: Pursuant to Rule 461 of Regulation C of the General Rules and Regulations under the

April 18, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 18, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defi

April 5, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

March 19, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 19, 2024 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission F

March 19, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) Tyra Biosciences, Inc.

March 19, 2024 EX-99.1

Tyra Biosciences Reports Fourth Quarter and Full Year 2023 Financial Results and Highlights - Advanced SURF301 Phase 1 oncology study; Initial Phase 1 results to be reported in 2H 2024 - - TYRA-300 Phase 2 ACH IND submission on track for 2H 2024 - -

Exhibit 99.1 Tyra Biosciences Reports Fourth Quarter and Full Year 2023 Financial Results and Highlights - Advanced SURF301 Phase 1 oncology study; Initial Phase 1 results to be reported in 2H 2024 - - TYRA-300 Phase 2 ACH IND submission on track for 2H 2024 - - Initiated SURF201 Phase 1 study and dosed first patient with TYRA-200 - - Strengthened balance sheet with approximately $200 million PIPE

March 19, 2024 EX-10.23

Third Amendment to Lease, between the Registrant and Fabric 2676 State, LLC, a California limited liability company, dated March 18, 2024

Exhibit 10.23 THIRD AMENDMENT TO LEASE This Third Amendment to Lease (this “Amendment”) is made and entered into as of March 18, 2024, by and between Fabric 2676 State Street, LLC, a California limited liability company (“Lessor”), and TYRA Biosciences, Inc., a Delaware corporation (“Lessee”). RECITALS A. Lessor and Lessee are parties to that certain AIR Standard Industrial/Commercial Multi-Tenant

March 19, 2024 S-8

As filed with the Securities and Exchange Commission on March 19, 2024

As filed with the Securities and Exchange Commission on March 19, 2024 Registration No.

March 19, 2024 S-3

As filed with the Securities and Exchange Commission on March 19, 2024

S-3 Table of Contents As filed with the Securities and Exchange Commission on March 19, 2024 Registration No.

March 19, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40800 TYRA BIOSCIENCE

March 19, 2024 EX-97.1

Policy for Recovery of Erroneously Awarded Compensation

Exhibit 97.1 TYRA BIOSCIENCES, INC. POLICY FOR RECOVERY OF ERRONEOUSLY AWARDED COMPENSATION Tyra Biosciences, Inc. (the “Company”) has adopted this Policy for Recovery of Erroneously Awarded Compensation (the “Policy”), effective as of October 2, 2023 (the “Effective Date”). Capitalized terms used in this Policy but not otherwise defined herein are defined in Section 11. 1. Persons Subject to Poli

March 19, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-8 (Form Type) Tyra Biosciences, Inc.

February 14, 2024 SC 13G/A

TYRA / Tyra Biosciences, Inc. / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 1 TO SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106 (CUSIP Number)

February 9, 2024 SC 13G/A

TYRA / Tyra Biosciences, Inc. / FMR LLC Passive Investment

SC 13G/A 1 filing.txt SCHEDULE 13G Amendment No.2 TYRA BIOSCIENCES INC COMMON STOCK Cusip #90240B106 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [x] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #90240B106 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 2,768,497 Item 6: 0 Item 7: 2,768,696 Item 8: 0 Item 9

February 8, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / Boxer Capital, LLC Activist Investment

SC 13D/A 1 ff300290813da-tyra.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (RULE 13D - 101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a) (Amendment No. 2)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106 (CUS

February 6, 2024 SC 13D/A

TYRA / Tyra Biosciences, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment 1)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 90240B106 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Name, A

February 5, 2024 EX-10.1

Securities Purchase Agreement, dated February 1, 2024, by and between the Registrant and each of the purchasers party thereto

Exhibit 10.1 TYRA BIOSCIENCES, INC. SECURITIES PURCHASE AGREEMENT THIS SECURITIES PURCHASE AGREEMENT (the “Agreement”) is made as of February 1, 2024 (the “Effective Date”), by and between TYRA BIOSCIENCES, INC., a Delaware corporation (the “Company”), and each of the purchasers whose names and addresses are set forth on Schedule A hereto (each, a “Purchaser” and, collectively, the “Purchasers”).

February 5, 2024 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY OTHER APPLICABLE SECURITIES LAWS AND HAVE BEEN ISSUED IN RELIANCE UPON AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND SUCH OTHER SECURITIES LAWS. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE

February 5, 2024 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 1, 2024 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commission

February 5, 2024 EX-99.1

Tyra Biosciences, Inc. Announces $200 Million Private Placement Financing

Exhibit 99.1 Tyra Biosciences, Inc. Announces $200 Million Private Placement Financing CARLSBAD, Calif., February 2, 2024 – Tyra Biosciences, Inc. (Nasdaq: TYRA), a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptor (FGFR) biology, announced today that it has entered into a securities p

February 1, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 1, 2024 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commission

December 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 22, 2023 TYRA BIOSCIENCE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 22, 2023 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commissio

November 7, 2023 EX-10.1

Non-Employee Director Compensation Program, amended and restated effective August 1, 2023

Exhibit 10.1 Tyra Biosciences, Inc. Non-Employee Director Compensation Program (Amended and Restated Effective August 1, 2023) Non-employee members of the board of directors (the “Board”) of Tyra Biosciences, Inc. (the “Company”) shall receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”). The cash and equity compensation described in

November 7, 2023 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

November 7, 2023 EX-99.1

Tyra Biosciences Reports Third Quarter 2023 Financial Results and Highlights - Enrollment and dose escalation ongoing in SURF301 Phase 1/2 oncology - - Presented additional preclinical data on TYRA-300 in achondroplasia at ASBMR and ASHG - - First pa

Exhibit 99.1 Tyra Biosciences Reports Third Quarter 2023 Financial Results and Highlights - Enrollment and dose escalation ongoing in SURF301 Phase 1/2 oncology - - Presented additional preclinical data on TYRA-300 in achondroplasia at ASBMR and ASHG - - First patient to be dosed in TYRA-200 Phase 1 by YE 2023 - - Strong cash position of $215.7 million as of Q3 2023 - CARLSBAD, Calif., November 7,

November 7, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 07, 2023 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commissio

October 26, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 26, 2023 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commission

October 26, 2023 EX-3.2

Amended and Restated Bylaws

Exhibit 3.2 Amended and Restated Bylaws of Tyra Biosciences, Inc. (a Delaware corporation) as of October 26, 2023 Table of Contents Page ArticleARTICLE I - Corporate Offices 1 1.1 Registered Office 1 1.2 Other Offices 1 ArticleARTICLE II - Meetings of Stockholders 1 2.1 Place of Meetings 1 2.2 Annual Meeting 1 2.3 Special Meeting 1 2.4 Notice of Business to be Brought beforeBefore a Meeting. 22 2.

October 26, 2023 EX-3.1

Amended and Restated Bylaws, effective as of October 26, 2023

Exhibit 3.1 Amended and Restated Bylaws of Tyra Biosciences, Inc. (a Delaware corporation) as of October 26, 2023 Table of Contents Page ARTICLE I - Corporate Offices 1 1.1 Registered Office 1 1.2 Other Offices 1 ARTICLE II - Meetings of Stockholders 1 2.1 Place of Meetings 1 2.2 Annual Meeting 1 2.3 Special Meeting 1 2.4 Notice of Business to be Brought Before a Meeting 2 2.5 Notice of Nomination

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2023 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

August 10, 2023 EX-99.1

Tyra Biosciences Reports Second Quarter 2023 Financial Results and Highlights -Orphan Drug Designation granted to TYRA-300 for achondroplasia- - SURF301 Phase 1/2 oncology study remains on target; enrollment ongoing in Part B - -TYRA-200 Phase 1 stud

Exhibit 99.1 Tyra Biosciences Reports Second Quarter 2023 Financial Results and Highlights -Orphan Drug Designation granted to TYRA-300 for achondroplasia- - SURF301 Phase 1/2 oncology study remains on target; enrollment ongoing in Part B - -TYRA-200 Phase 1 study on track; first patient to be dosed in 2H 2023- - Strong cash position of $232.4 million as of Q2 2023- CARLSBAD, Calif., August 10, 20

August 10, 2023 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

June 2, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 31, 2023 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commission Fil

May 4, 2023 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

May 4, 2023 EX-99

Tyra Biosciences Reports First Quarter 2023 Financial Results and Highlights -SURF301 Phase 1/2 oncology study continues to advance- - Expanded TYRA-300 clinical development into achondroplasia- -IND for TYRA-200 cleared with Phase 1 study on track f

Exhibit 99.1 Tyra Biosciences Reports First Quarter 2023 Financial Results and Highlights -SURF301 Phase 1/2 oncology study continues to advance- - Expanded TYRA-300 clinical development into achondroplasia- -IND for TYRA-200 cleared with Phase 1 study on track for 2H 2023- -Strong cash position of $241.7 million as of Q1 2023- CARLSBAD, Calif., May 4, 2023 – Tyra Biosciences, Inc. (Nasdaq: TYRA),

May 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 04, 2023 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission Fil

April 17, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 17, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 22, 2023 EX-10

Second Amendment to Lease, between the Registrant and Fabric 2656 State, LLC, a California limited liability company, dated December 20, 2022

Exhibit 10.19 SECOND AMENDMENT TO LEASE This Second Amendment to Lease (this “Amendment”) is made and entered into as of December 20, 2022, by and between Fabric 2656 State, LLC, a California limited liability company (“Lessor”), and TYRA Biosciences, Inc., a Delaware corporation (“Lessee”). RECITALS A. Lessor and Lessee are parties to that certain AIR Standard Industrial/Commercial Multi-Lessee L

March 22, 2023 EX-99

Tyra Biosciences Reports Fourth Quarter and Full Year 2022 Financial Results and Highlights -Initiated patient dosing with TYRA-300 in SURF301 oncology study- -Expanded pipeline beyond oncology into genetically defined conditions with TYRA-300 for ac

Exhibit 99.1 Tyra Biosciences Reports Fourth Quarter and Full Year 2022 Financial Results and Highlights -Initiated patient dosing with TYRA-300 in SURF301 oncology study- -Expanded pipeline beyond oncology into genetically defined conditions with TYRA-300 for achondroplasia- -Cleared IND for TYRA-200 Phase 1 study; first patient dosed expected in 2H 2023 - -Well-capitalized with cash and cash equ

March 22, 2023 EX-10

Second Amendment to Lease, between the Registrant and Fabric 2676 State, LLC, a California limited liability company, dated January 6, 2023

Exhibit 10.22 SECOND AMENDMENT TO LEASE This Second Amendment to Lease (this “Amendment”) is made and entered into as of January 6, 2023, by and between Fabric 2676 State Street, LLC, a California limited liability company (“Lessor”), and TYRA Biosciences, Inc., a Delaware corporation (“Lessee”). RECITALS A. Lessor and Lessee are parties to that certain AIR Standard Industrial/Commercial Multi-Ten

March 22, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40800 TYRA BIOSCIENCE

March 22, 2023 EX-10

Employment Letter Agreement, dated December 31, 2022, by and between Alan Fuhrman and the Registrant

Exhibit 10.14 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is effective as of December 31, 2022 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Alan Fuhrman (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwise defined shall have those meanings

March 22, 2023 EX-10

Consulting Agreement, dated January 1, 2023, by and between Esther van den Boom and the Registrant

Exhibit 10.16 CONSULTING AGREEMENT This Consulting Agreement (the “Agreement”) is effective as of January 1, 2023 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”), and Esther van den Boom (“Advisor”). RECITALS Whereas, Advisor has been employed by the Company as its Chief Financial Officer; Whereas, Advisor and the Company are parties to that ce

March 22, 2023 EX-3

Amended and Restated Certificate of Incorporation

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. Tyra Biosciences, Inc. (the "Corporation"), a corporation organized and existing under the General Corporation Law of the State of Delaware (the "DGCL"), does hereby certify as follows: 1. The name of the Corporation is Tyra Biosciences, Inc. The Corporation was incorporated under the name Tyra Biosciences, Inc

March 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 22, 2023 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission F

March 22, 2023 EX-10

Tyra Biosciences, Inc. Annual Bonus Plan

Exhibit 10.5 TYRA BIOSCIENCES, INC. ANNUAL BONUS PLAN 1. PURPOSE This Annual Bonus Plan (the “Plan”) is adopted under the Tyra Biosciences, Inc. 2021 Incentive Award Plan (the “2021 Plan”) and is intended to provide an incentive for eligible employees of Tyra Biosciences, Inc.(the “Company”) to perform to the best of their abilities, to further the growth, development and financial success of the

March 22, 2023 EX-10

First Amendment to Lease, between the Registrant and Fabric 2676 State, LLC, a California limited liability company, dated May 16, 2022

Exhibit 10.21 FIRST AMENDMENT TO LEASE This First Amendment to Lease (this “Amendment”) is made and entered into as of May 16, 2022, by and between Fabric 2676 State Street, LLC, a California limited liability company (“Lessor”), and TYRA Biosciences, Inc., a Delaware corporation (“Lessee”). RECITALS A. Lessor and Lessee are parties to that certain AIR Standard Industrial/Commercial Multi-Tenant L

March 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 27, 2023 TYRA BIOSCIENCE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 27, 2023 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commissio

November 29, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 29, 2022 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commissio

November 3, 2022 EX-99.1

Tyra Biosciences Reports Third Quarter 2022 Financial Results and Highlights -Pipeline on track; SURF301 study to be initiated; IND for TYRA-200 to be filed by year-end 2022- -Well-capitalized with cash and cash equivalents of $263.2 million as of Q3

Exhibit 99.1 Tyra Biosciences Reports Third Quarter 2022 Financial Results and Highlights -Pipeline on track; SURF301 study to be initiated; IND for TYRA-200 to be filed by year-end 2022- -Well-capitalized with cash and cash equivalents of $263.2 million as of Q3 2022- CARLSBAD, Calif., November 3, 2022 ? Tyra Biosciences, Inc. (Nasdaq: TYRA), a precision oncology company focused on developing pur

November 3, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 28, 2022 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

November 3, 2022 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

l UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

October 11, 2022 CORRESP

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008 October 11, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Tyra Biosciences, Inc. Registration Statement on Form S-3 File No. 333-267712 To the addressees set forth above: Pursuant to Rule 461 of Regulation C of the General Rules and Regulations under th

October 3, 2022 EX-1.2

ATM Sales Agreement, dated October 3, 2022, by and between Virtu Americas LLC and the Registrant

Exhibit 1.2 TYRA BIOSCIENCES, INC. Common Stock (par value $0.0001 per share) ATM Sales Agreement October 3, 2022 Virtu Americas LLC 1633 Broadway New York, NY 10019 Ladies and Gentlemen: Tyra Biosciences, Inc., a Delaware corporation (the ?Company?), confirms its agreement (this ?Agreement?) with Virtu Americas LLC (the ?Agent?) as follows: 1. Issuance and Sale of Shares. The Company agrees that,

October 3, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 3, 2022 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commission

October 3, 2022 EX-4.4

Form of Indenture.

Exhibit 4.4 TYRA BIOSCIENCES, INC. INDENTURE Dated as of , 20 [] Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 4 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 5 Section 2.1. Issuable in Series 5 Section 2.2. Establishm

October 3, 2022 EX-FILING FEES

Filing Fee Table.

EX-FILING FEES 7 d370610dexfilingfees.htm EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Tyra Biosciences, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggr

October 3, 2022 S-3

As filed with the Securities and Exchange Commission on October 3, 2022

Table of Contents As filed with the Securities and Exchange Commission on October 3, 2022 Registration No.

August 4, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 04, 2022 Tyra Biosciences, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40800 83-1476348 (State or Other Jurisdiction of Incorporation) (Commission

August 4, 2022 EX-99.1

Tyra Biosciences Reports Second Quarter 2022 Financial Results and Highlights -IND clearance received from FDA to proceed with SURF301 Study of TYRA-300- -Pipeline on track; IND for TYRA-200 to be filed in 2H 2022- -Well-capitalized with cash and cas

Exhibit 99.1 Tyra Biosciences Reports Second Quarter 2022 Financial Results and Highlights -IND clearance received from FDA to proceed with SURF301 Study of TYRA-300- -Pipeline on track; IND for TYRA-200 to be filed in 2H 2022- -Well-capitalized with cash and cash equivalents of $275.1 million as of Q2 2022- CARLSBAD, Calif., August 4, 2022 ? Tyra Biosciences, Inc. (Nasdaq: TYRA), a precision onco

August 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

August 4, 2022 EX-10.1

Employment Letter Agreement, dated May 16, 2022, by and between Ali Fawaz and the Registrant

TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is entered into this 16th day of May, 2022 (the ?Effective Date?), by and between Tyra Biosciences, Inc., a Delaware corporation (the ?Company?) and Ali Fawaz (?Executive? and, together with the Company, the ?Parties?). Capitalized terms used herein and not otherwise defined shall have those meanings set forth

June 16, 2022 SC 13D/A

TYRA / Tyra Tech Inc / Boxer Capital, LLC - SC 13D/A Activist Investment

SC 13D/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D (Rule 13d-101) Under the Securities Exchange Act of 1934 (Amendment No.

June 16, 2022 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13D and any amendments to it with respect to Common Stock, $0.

June 14, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 13, 2022 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation) (Commission Fi

May 5, 2022 EX-99.1

Tyra Biosciences Reports First Quarter 2022 Financial Results and Highlights -Pipeline on-track; INDs to be filed for TYRA-300 and TYRA-200 in 2022- -Well-capitalized with cash and cash equivalents of $292.5 million as of Q1 2022-

Exhibit 99.1 Tyra Biosciences Reports First Quarter 2022 Financial Results and Highlights -Pipeline on-track; INDs to be filed for TYRA-300 and TYRA-200 in 2022- -Well-capitalized with cash and cash equivalents of $292.5 million as of Q1 2022- CARLSBAD, Calif., May 5, 2022 – Tyra Biosciences, Inc. (Nasdaq: TYRA), a precision oncology company focused on developing purpose-built therapies to overcom

May 5, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 5, 2022 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation or organization)

May 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

April 28, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 d283123ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as

April 28, 2022 DEF 14A

Definitive Proxy Statement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

March 24, 2022 EX-99.1

Joint Filing Agreement

EX-99.1 2 ex991to13g07422tyra03242022.htm JOINT FILING AGREEMENT Exhibit 99.1 Joint Filing Agreement The undersigned hereby agree that the Statement on Schedule 13G dated March 24, 2022 with respect to the Common Stock, $0.0001 par value per share of Tyra Biosciences, Inc., a Delaware corporation, and any further amendments thereto executed by each and any of the undersigned shall be filed on beha

March 24, 2022 SC 13G

TYRA / Tyra Tech Inc / BIOTECHNOLOGY VALUE FUND L P - THE SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )1 Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106 (CUSIP Number) M

March 3, 2022 EX-10.14

First Amendment to Lease, between the Registrant and Fabric 2656 State, LLC, a California limited liability company, dated March 2, 2022

Exhibit 10.14 FIRST AMENDMENT TO LEASE This First Amendment to Lease (this ?Amendment?) is made and entered into as of March 2, 2022, by and between Fabric 2656 State, LLC, a California limited liability company (?Lessor?), and TYRA Biosciences, Inc., a Delaware corporation (?Lessee?). RECITALS A. Lessor and Lessee are parties to that certain AIR Standard Industrial/Commercial Multi-Lessee Lease -

March 3, 2022 EX-4.3

Description of Registered Securities

Exhibit 4.3 DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of December 31, 2021, Tyra Biosciences, Inc. (?we,? ?us? and ?our?) had one class of securities registered pursuant to Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?): our common stock. Description of Common Stock General The followin

March 3, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40800 TYRA BIOSCIENCE

March 3, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 3, 2022 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation or organization

March 3, 2022 EX-10.15

Office Lease, between the Registrant and Fabric 2676 State Street, LLC, a California limited liability company, dated March 2, 2022

Exhibit 10.15 STANDARD INDUSTRIAL/COMMERCIAL MULTI-TENANT LEASE - NET 1. Basic Provisions (?Basic Provisions?). 1.1 Parties. This Lease (?Lease?), dated for reference purposes only March 2, 2022, is made by and between Fabric 2676 State Street, LLC, a California limited liability company (?Lessor?) and TYRA Biosciences, Inc., a Delaware corporation (?Lessee?), (collectively the ?Parties?, or indiv

March 3, 2022 EX-10.12

Employment Letter Agreement, dated August 19, 2021, by and between John Healy and the Registrant

Exhibit 10.12 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into as of August 19, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and John Healy (“Executive” and, together with the Company, the “Parties”). This Agreement will be effective upon the consummation of the Company’s initial public offering (the “IPO

March 3, 2022 EX-99.1

Tyra Biosciences Reports Fourth Quarter and Full Year 2021 Financial Results and Highlights -Pipeline on-track; INDs expected to be filed for TYRA-300 and TYRA-200 in 2022- -Strengthened organization with key appointment to clinical team- -Well-capit

Exhibit 99.1 Tyra Biosciences Reports Fourth Quarter and Full Year 2021 Financial Results and Highlights -Pipeline on-track; INDs expected to be filed for TYRA-300 and TYRA-200 in 2022- -Strengthened organization with key appointment to clinical team- -Well-capitalized with cash and cash equivalents of $302.2 million as of YE 2021- CARLSBAD, Calif., March 3, 2022 ? Tyra Biosciences, Inc. (Nasdaq:

February 8, 2022 EX-99.24

2018 POWER OF ATTORNEY

EX-99.24 2 d304292dex9924.htm EXHIBIT 24 Exhibit 24 2018 POWER OF ATTORNEY 1. Appointment, Powers and Revocation. KNOW ALL MEN BY THESE PRESENTS, that each undersigned, and if such undersigned is not a natural person, acting by and through one of its authorized representatives (each such undersigned person or entity, a “Grantor”), effective from the date set forth opposite the name of such Grantor

February 8, 2022 EX-99.1

Joint Filing Agreement

EXHIBIT 99.1 Joint Filing Agreement The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be

February 8, 2022 SC 13G

TYRA / Tyra Tech Inc / Canaan XI L.P. - SC 13G Passive Investment

SC 13G 1 d304292dsc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Tyra Biosciences, Inc. (Name of Issuer) COMMON STOCK, $0.0001 PAR VALUE PER SHARE (Title of Class of Securities) 90240B 106 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check th

November 3, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

November 3, 2021 EX-99.1

Tyra Biosciences Reports Third Quarter 2021 Financial Results and Highlights -Successful completion of upsized $198.7 million initial public offering; cash and cash equivalents of $312.8 million as of September 30, 2021- -Nominated 2nd product candid

Exhibit 99.1 Tyra Biosciences Reports Third Quarter 2021 Financial Results and Highlights -Successful completion of upsized $198.7 million initial public offering; cash and cash equivalents of $312.8 million as of September 30, 2021- -Nominated 2nd product candidate for clinical development, TYRA-200 (FGFR2 inhibitor), from its SN?P platform- -Strengthened team with appointments of Esther van den

November 3, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 3, 2021 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of incorporation or organizat

September 29, 2021 SC 13G/A

TCG Crossover Management, LLC - AMENDMENT NO. 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 90240B106 (CUSIP Number) September 15, 2021 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pur

September 27, 2021 EX-99.A

JOINT FILING STATEMENT

Exhibit 99.A EXHIBIT A JOINT FILING STATEMENT We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the Common Stock of Tyra Biosciences, Inc. is filed on behalf of each of us. Dated: September 27, 2021 Nextech VI Oncology SCSp By: Nextech VI GP S.? r.l. its General Partner By: /s/ Dalia Bleyer Dalia Bleyer, Managing Member By: /s/

September 27, 2021 SC 13D

RA CAPITAL MANAGEMENT, L.P. - SCHEDULE 13D

SC 13D 1 tm2128529d1sc13d.htm SCHEDULE 13D SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment )* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 90240B106 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kol

September 27, 2021 SC 13D

Alta Partners NextGen Fund II Management, LLC - SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 90240B106 (CUSIP Number) Larry Randall Alta Partners NextGen Fund II Management, LLC 115 W Snow King Ave, Suite 101B Jackson, WY 83001 (415) 3

September 27, 2021 SC 13G

NEXTECH VI ONCOLOGY SCSP - SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 90240B106 (CUSIP Number) September 17, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

September 24, 2021 SC 13D

Boxer Capital, LLC - SC 13D

SC 13D 1 d237021dsc13d.htm SC 13D SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D (Rule 13d-101) Under the Securities Exchange Act of 1934 (Amendment No. )* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 90240B106 (CUSIP Number) David A. Brown Alston & Bird LLP 950 F Street, N.W. Washington, DC 20004-1404 202-23

September 24, 2021 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 d237021dex991.htm EX-99.1 EXHIBIT 1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13D and any amendments to it with respect to Common Stock, $0.0001 par value per share, of Tyra Biosciences, Inc. and further agree that

September 21, 2021 SC 13G

TCG Crossover Management, LLC

SC 13G 1 p921210sc13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Tyra Biosciences, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 90240B106 (CUSIP Number) September 15, 2021 (Date of Event Which Requires Filing of This Statement) Check the appropriate box

September 17, 2021 EX-3.1

Amended and Restated Certificate of Incorporation

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. Tyra Biosciences, Inc. (the “Corporation”), a corporation organized and existing under the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify as follows: 1. The name of the Corporation is Tyra Biosciences, Inc. The Corporation was incorporated under the name Tyra Biosciences, Inc

September 17, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Other Events

8-K 1 d220261d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): September 17, 2021 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-40800 83-1476348 (State or other jurisdiction of

September 17, 2021 EX-3.2

Amended and Restated Bylaws

Exhibit 3.2 Amended and Restated Bylaws of Tyra Biosciences, Inc. (a Delaware corporation) Table of Contents Page Article I—Corporate Offices 1 1.1 Registered Office 1 1.2 Other Offices 1 Article II—Meetings of Stockholders 1 2.1 Place of Meetings 1 2.2 Annual Meeting 1 2.3 Special Meeting 1 2.4 Notice of Business to be Brought before a Meeting 2 2.5 Notice of Nominations for Election to the Board

September 15, 2021 424B4

10,800,000 Shares Common Stock

424B4 1 d189651d424b4.htm 424B4 Table of Contents Filed Pursuant to Rule 424(b)(4) Registration Nos. 333-258970 and 333-259531 PROSPECTUS 10,800,000 Shares Common Stock This is Tyra Biosciences, Inc.’s initial public offering. We are selling 10,800,000 shares of our common stock. Prior to this offering, there has been no public market for our common stock. The initial public offering price per sha

September 15, 2021 S-8

As filed with the Securities and Exchange Commission on September 15, 2021

As filed with the Securities and Exchange Commission on September 15, 2021 Registration No.

September 14, 2021 S-1/A

Form S-1

Table of Contents As filed with the Securities and Exchange Commission on September 14, 2021 Registration No.

September 14, 2021 S-1MEF

As filed with the Securities and Exchange Commission on September 14, 2021

As filed with the Securities and Exchange Commission on September 14, 2021 Registration No.

September 10, 2021 CORRESP

[Signature Page Follows]

September 10, 2021 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

September 10, 2021 CORRESP

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008

Tyra Biosciences, Inc. 2656 State Street Carlsbad, CA 92008 September 10, 2021 VIA EDGAR Mr. Dillon Hagius Office of Life Sciences Division of Corporation Finance U.S. Securities and Exchange Commission 100 F Street N.E. Washington, D.C. 20549 Re: Tyra Biosciences, Inc. Registration Statement on Form S-1 File No. 333-258970 Dear Mr. Hagius: Pursuant to Rule 461 of Regulation C of the General Rules

September 10, 2021 8-A12B

Form 8-A

8-A12B 1 d213200d8a12b.htm 8-A12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 83-1476348 (State of incorporation or organization) (I.R.S. Employer Identif

September 9, 2021 EX-10.3

Tyra Biosciences, Inc. 2021 Employee Stock Purchase Plan

EX-10.3 7 d189651dex103.htm EX-10.3 Exhibit 10.3 TYRA BIOSCIENCES, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE The purpose of this Plan is to assist Eligible Employees of the Company and its Designated Subsidiaries in acquiring a stock ownership interest in the Company. The Plan consists of two components: (i) the Section 423 Component and (ii) the Non-Section 423 Component. The Sect

September 9, 2021 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 Tyra Biosciences, Inc. (a Delaware corporation) [?] Shares of Common Stock UNDERWRITING AGREEMENT Dated: [?], 2021 Tyra Biosciences, Inc. (a Delaware corporation) [?] Shares of Common Stock UNDERWRITING AGREEMENT [?], 2021 BofA Securities, Inc. Jefferies LLC Cowen and Company, LLC as Representatives of the several Underwriters c/o BofA Securities, Inc. One Bryant Park New York, New Yor

September 9, 2021 S-1/A

As filed with the Securities and Exchange Commission on September 9, 2021

S-1/A Table of Contents As filed with the Securities and Exchange Commission on September 9, 2021 Registration No.

September 9, 2021 EX-3.1

Amended and Restated Certificate of Incorporation, as amended (currently in effect)

EX-3.1 3 d189651dex31.htm EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Tyra Biosciences, Inc., a corporation organized and existing under and by virtue of the provisions of the Genera

September 9, 2021 EX-4.2

Amended and Restated Investors’ Rights Agreement, dated March 5, 2021, by and among the Registrant and certain of its stockholders

Exhibit 4.2 Execution Version AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT CONTENTS Page 1.???Definitions 1 2.???Registration Rights 4 2.1??Demand Registration 4 2.2??Company Registration 6 2.3??Underwriting Requirements 6 2.4??Obligations of the Company 8 2.5??Furnish Information 9 2.6??Expenses of Registration 9 2.7??Delay of Registration 10 2.8??Indemnification 10 2.9??Reports Under Exchang

September 9, 2021 EX-10.4

Non-Employee Director Compensation Program

EX-10.4 8 d189651dex104.htm EX-10.4 Exhibit 10.4 TYRA BIOSCIENCES, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM Non-employee members of the board of directors (the “Board”) of Tyra Biosciences, Inc. (the “Company”) shall receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”). The cash and equity compensation described in this Progra

September 9, 2021 EX-10.2

Tyra Biosciences, Inc. 2021 Incentive Award Plan and form of stock option grant notice and stock option agreement thereunder

EX-10.2 6 d189651dex102.htm EX-10.2 Exhibit 10.2 TYRA BIOSCIENCES, INC. 2021 INCENTIVE AWARD PLAN ARTICLE I. PURPOSE The Plan’s purpose is to enhance the Company’s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by providing these individuals with equity ownership opportunities and/or equity-linked compensatory opportunities

August 20, 2021 EX-3.1

Amended and Restated Certificate of Incorporation (currently in effect)

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Tyra Biosciences, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of

August 20, 2021 EX-10.6

Amended and Restated Employment Agreement, dated January 6, 2020, by and between Daniel Bensen and the Registrant

Exhibit 10.6 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into this 6th day of January, 2020 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Dan Bensen (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and

August 20, 2021 CORRESP

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12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh Düsseldorf San Diego August 20, 2021 Frankfurt San Francisco Hamburg Seoul Hong Kong Shanghai VIA EDGAR Houston Silicon Valley London Singapore Mr. Dillon Hagius Los Ange

August 20, 2021 EX-10.19

Office Lease, between the Registrant and Fabric 2656 State, LLC, a California limited liability company, as amended by Addendum dated August 5, 2020

Exhibit 10.19 STANDARD INDUSTRIAL/COMMERCIAL MULTI-TENANT LEASE - NET 1. Basic Provisions (?Basic Provisions?). 1.1 Parties. This Lease (?Lease?), dated for reference purposes only August 5, 2020, is made by and between Fabric 2656 State, LLC, a California limited liability company (?Lessor?) and TYRA Biosciences, Inc., a Delaware corporation (?Lessee?), (collectively the ?Parties?, or individuall

August 20, 2021 EX-10.16

Amended and Restated Employment Letter Agreement, dated August 18, 2021, by and between Hiroomi Tada and the Registrant

EX-10.16 20 d189651dex1016.htm EX-10.16 Exhibit 10.16 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into as of August 18, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Hiroomi Tada (“Executive” and, together with the Company, the “Parties”). This Agreement will b

August 20, 2021 CORRESP

12670 High Bluff Drive

12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh Düsseldorf San Diego Frankfurt San Francisco Hamburg Seoul Hong Kong Shanghai Houston Silicon Valley London Singapore Los Angeles Tokyo Madrid Washington, D.C. Milan FOIA

August 20, 2021 EX-3.3

Form of Amended and Restated Certificate of Incorporation (to be effective immediately prior to the completion of this offering)

EX-3.3 4 d189651dex33.htm EX-3.3 Exhibit 3.3 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. Tyra Biosciences, Inc. (the “Corporation”), a corporation organized and existing under the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify as follows: 1. The name of the Corporation is Tyra Biosciences, Inc. The Corporation was incorporated und

August 20, 2021 EX-4.1

Specimen stock certificate evidencing the shares of common stock

EX-4.1 6 d189651dex41.htm EX-4.1 Exhibit 4.1 TYRA PO BOX 505006, Louisville, KY 40233-5006 MR A SAMPLE DESIGNATION (IF ANY) ADD 1 ADD 2 ADD 3 ADD 4 CUSIP/IDENTIFIER XXXXXX XX X Holder ID XXXXXXXXXX Insurance Value 1,000,000.00 Number of Shares 123456 DTC 12345678 123456789012345 Certificate Numbers 1234567890/1234567890 1234567890/1234567890 1234567890/1234567890 1234567890/1234567890 1234567890/1

August 20, 2021 EX-3.2

Bylaws (currently in effect)

Exhibit 3.2 BYLAWS OF TYRA BIOSCIENCES, INC. (A DELAWARE CORPORATION) Dated as of August 2, 2018 TABLE OF CONTENTS Page ARTICLE I STOCKHOLDERS’ ACTIONS 1 Section 1.1 Place of Meetings 1 Section 1.2 Annual Meeting 1 Section 1.3 Special Meetings 2 Section 1.4 Notice of Meetings 2 Section 1.5 Adjournment and Notice of Adjourned Meetings 2 Section 1.6 Record Date 2 Section 1.7 Quorum 3 Section 1.8 Vot

August 20, 2021 EX-10.9

Employment Agreement, dated November 9, 2020, by and between Hiroomi Tada and the Registrant

Exhibit 10.9 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is entered into this 9th day of November, 2020 (the ?Effective Date?), by and between Tyra Biosciences, Inc., a Delaware corporation (the ?Company?) and Hiroomi Tada (?Executive? and, together with the Company, the ?Parties?). Capitalized terms used herein and not otherwise defined shall have those

August 20, 2021 EX-10.8

Employment Agreement, dated January 16, 2020, by and between Ronald Swanson and the Registrant

Exhibit 10.8 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into this 16th day of January, 2020 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Ronald Swanson (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwise defined shall have tho

August 20, 2021 EX-10.17

Amended and Restated Employment Agreement, dated August 18, 2021, by and between Robert Hudkins and the Registrant

Exhibit 10.17 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the ?Agreement?) is entered into as of August 18, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the ?Company?) and Robert Hudkins (?Executive? and, together with the Company, the ?Parties?). This Agreement will be effective upon the consummation of t

August 20, 2021 EX-10.7

Employment Agreement, dated April 16, 2021, by and between Esther van den Boom and the Registrant

Exhibit 10.7 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into this 16th day of April, 2021 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Esther van den Boom (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwise defined shall have

August 20, 2021 EX-3.4

Form of Amended and Restated Bylaws (to be effective immediately prior to the completion of this offering)

Exhibit 3.4 Amended and Restated Bylaws of Tyra Biosciences, Inc. (a Delaware corporation) Table of Contents Page Article I - Corporate Offices 1 1.1 Registered Office 1 1.2 Other Offices 1 Article II - Meetings of Stockholders 1 2.1 Place of Meetings 1 2.2 Annual Meeting 1 2.3 Special Meeting 1 2.4 Notice of Business to be Brought before a Meeting 2 2.5 Notice of Nominations for Election to the B

August 20, 2021 EX-10.10

Employment Agreement, dated January 1, 2021, by and between Robert Hudkins and the Registrant

Exhibit 10.10 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is entered into this 1st day of January, 2021 (the ?Effective Date?), by and between Tyra Biosciences, Inc., a Delaware corporation (the ?Company?) and Robert Hudkins (?Executive? and, together with the Company, the ?Parties?). Capitalized terms used herein and not otherwise defined shall have tho

August 20, 2021 EX-10.12

Second Amended and Restated Employment Letter Agreement, dated August 18, 2021, by and between Todd Harris and the Registrant

Exhibit 10.12 TYRA BIOSCIENCES, INC. SECOND AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Second Amended and Restated Employment Agreement (the “Agreement”) is entered into as of August 18, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Todd Harris (“Executive” and, together with the Company, the “Parties”). This Agreement will be effective upon the consum

August 20, 2021 EX-10.15

Amended and Restated Employment Letter Agreement, dated August 18, 2021, by and between Ronald Swanson and the Registrant

Exhibit 10.15 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the ?Agreement?) is entered into as of August 18, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the ?Company?) and Ronald Swanson (?Executive? and, together with the Company, the ?Parties?). This Agreement will be effective upon the consummation of t

August 20, 2021 EX-4.2

Amended and Restated Investors’ Rights Agreement, dated March 5, 2021, by and among the Registrant and certain of its stockholders

Exhibit 4.2 Execution Version AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT CONTENTS Page 1.   Definitions 1 2.   Registration Rights 4 2.1  Demand Registration 4 2.2  Company Registration 6 2.3  Underwriting Requirements 6 2.4  Obligations of the Company 8 2.5  Furnish Information 9 2.6  Expenses of Registration 9 2.7  Delay of Registration 10 2.8  Indemnification 10 2.9  Reports Under Exchang

August 20, 2021 EX-10.11

Employment Agreement, dated January 18, 2021, by and between Piyush Patel and the Registrant

EX-10.11 15 d189651dex1011.htm EX-10.11 Exhibit 10.11 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into this 18th day of January, 2021 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Piyush Patel (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein a

August 20, 2021 EX-10.20

Form of Indemnification Agreement for Directors and Officers

EX-10.20 24 d189651dex1020.htm EX-10.20 Exhibit 10.20 INDEMNIFICATION AGREEMENT This Indemnification Agreement (“Agreement”) is made as of , 20 by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”), and , [a member of the Board of Directors/ an officer] of the Company (“Indemnitee”). This Agreement supersedes and replaces any and all previous Agreements between the Company

August 20, 2021 EX-10.13

Second Amended and Restated Employment Letter Agreement, dated August 18, 2021, by and between Daniel Bensen and the Registrant

Exhibit 10.13 TYRA BIOSCIENCES, INC. SECOND AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Second Amended and Restated Employment Agreement (the ?Agreement?) is entered into as of August 18, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the ?Company?) and Daniel Bensen (?Executive? and, together with the Company, the ?Parties?). This Agreement will be effective upon the cons

August 20, 2021 S-1

Power of Attorney (included on signature page)

S-1 Table of Contents As filed with the Securities and Exchange Commission on August 20, 2021 Registration No.

August 20, 2021 EX-10.18

Amended and Restated Employment Letter Agreement, dated August 18, 2021, by and between Piyush Patel and the Registrant

EX-10.18 22 d189651dex1018.htm EX-10.18 Exhibit 10.18 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into as of August 18, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Piyush Patel (“Executive” and, together with the Company, the “Parties”). This Agreement will b

August 20, 2021 EX-10.14

Amended and Restated Employment Letter Agreement, dated August 18, 2021, by and between Esther van den Boom and the Registrant

EX-10.14 18 d189651dex1014.htm EX-10.14 Exhibit 10.14 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into as of August 18, 2021, by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Esther van den Boom (“Executive” and, together with the Company, the “Parties”). This Agreement

August 20, 2021 EX-10.1

Tyra Biosciences, Inc. 2020 Equity Incentive Plan and form of stock option agreement thereunder

EX-10.1 8 d189651dex101.htm EX-10.1 Exhibit 10.1 TYRA BIOSCIENCES, INC. 2020 Equity Incentive Plan Adopted by the Board of Directors: January 6, 2020 Approved by the Stockholders: January 6, 2020 Termination Date: January 6, 2030 1. General. (a) Purpose. Tyra Biosciences, Inc. (the “Company”) hereby establishes this 2019 Equity Incentive Plan (the “Plan”). This Plan is intended: (i) to attract and

August 20, 2021 EX-10.5

Amended and Restated Employment Agreement, dated January 6, 2020, by and between Todd Harris and the Registrant

Exhibit 10.5 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into this 6th day of January, 2020 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Todd Harris (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein an

July 2, 2021 EX-10.7

TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT

EX-10.7 5 filename5.htm Exhibit 10.7 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into this 16th day of April, 2021 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Esther van den Boom (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not other

July 2, 2021 EX-10.6

TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT

EX-10.6 4 filename4.htm Exhibit 10.6 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into this 6th day of January, 2020 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Dan Bensen (“Executive” and, together with the Company, the “Parties”). Capitaliz

July 2, 2021 EX-10.5

TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT

EX-10.5 3 filename3.htm Exhibit 10.5 TYRA BIOSCIENCES, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into this 6th day of January, 2020 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Todd Harris (“Executive” and, together with the Company, the “Parties”). Capitali

July 2, 2021 EX-10.11

TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT

Exhibit 10.11 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is entered into this 18th day of January, 2021 (the ?Effective Date?), by and between Tyra Biosciences, Inc., a Delaware corporation (the ?Company?) and Piyush Patel (?Executive? and, together with the Company, the ?Parties?). Capitalized terms used herein and not otherwise defined shall have thos

July 2, 2021 DRS/A

As confidentially submitted to the Securities and Exchange Commission on July 2, 2021 as Amendment No. 1 to the draft Registration Statement.

DRS/A 1 filename1.htm Table of Contents As confidentially submitted to the Securities and Exchange Commission on July 2, 2021 as Amendment No. 1 to the draft Registration Statement. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 TYRA BIOSCIENCES, INC. (Exact name of registrant as specifi

July 2, 2021 EX-10.1

TYRA BIOSCIENCES, INC. 2020 Equity Incentive Plan Adopted by the Board of Directors: January 6, 2020 Approved by the Stockholders: January 6, 2020 Termination Date: January 6, 2030

EX-10.1 2 filename2.htm Exhibit 10.1 TYRA BIOSCIENCES, INC. 2020 Equity Incentive Plan Adopted by the Board of Directors: January 6, 2020 Approved by the Stockholders: January 6, 2020 Termination Date: January 6, 2030 1. General. (a) Purpose. Tyra Biosciences, Inc. (the “Company”) hereby establishes this 2019 Equity Incentive Plan (the “Plan”). This Plan is intended: (i) to attract and retain the

July 2, 2021 DRSLTR

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12670 High Bluff Drive San Diego, California 92130 Tel: +1.858.523.5400 Fax: +1.858.523.5450 www.lw.com FIRM / AFFILIATE OFFICES Beijing Moscow Boston Munich Brussels New York Century City Orange County Chicago Paris Dubai Riyadh D?sseldorf San Diego Frankfurt San Francisco Hamburg Seoul Hong Kong Shanghai Houston Silicon Valley London Singapore Los Angeles Tokyo Madrid Washington, D.C. Milan July

July 2, 2021 EX-10.9

TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT

EX-10.9 7 filename7.htm Exhibit 10.9 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into this 9th day of November, 2020 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Hiroomi Tada (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwise

July 2, 2021 EX-10.10

TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT

EX-10.10 8 filename8.htm Exhibit 10.10 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into this 1st day of January, 2021 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Robert Hudkins (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwi

July 2, 2021 EX-10.8

TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT

EX-10.8 6 filename6.htm Exhibit 10.8 TYRA BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into this 16th day of January, 2020 (the “Effective Date”), by and between Tyra Biosciences, Inc., a Delaware corporation (the “Company”) and Ronald Swanson (“Executive” and, together with the Company, the “Parties”). Capitalized terms used herein and not otherwis

May 28, 2021 DRS

As confidentially submitted to the Securities and Exchange Commission on May 28, 2021.

DRS 1 filename1.htm Table of Contents As confidentially submitted to the Securities and Exchange Commission on May 28, 2021. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 TYRA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 2834 83-1476348 (State or oth

May 28, 2021 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION TYRA BIOSCIENCES, INC.

EX-3.1 2 filename2.htm Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF TYRA BIOSCIENCES, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Tyra Biosciences, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporat

May 28, 2021 EX-3.2

BYLAWS TYRA BIOSCIENCES, INC. (A DELAWARE CORPORATION) Dated as of August 2, 2018

EX-3.2 3 filename3.htm Exhibit 3.2 BYLAWS OF TYRA BIOSCIENCES, INC. (A DELAWARE CORPORATION) Dated as of August 2, 2018 TABLE OF CONTENTS Page ARTICLE I STOCKHOLDERS’ ACTIONS 1 Section 1.1 Place of Meetings 1 Section 1.2 Annual Meeting 1 Section 1.3 Special Meetings 2 Section 1.4 Notice of Meetings 2 Section 1.5 Adjournment and Notice of Adjourned Meetings 2 Section 1.6 Record Date 2 Section 1.7 Q

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