ADAP Insider Trading - Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock)

Saham Orang Dalam	786,266,474 shares
Jumlah Orang Dalam	41

Skor Sentimen Orang Dalam

Skor Sentimen Orang Dalam mendapati syarikat dibeli oleh orang dalam korporat.

Ia adalah hasil daripada model kuantitatif berbilang faktor yang canggih yang mengenal pasti syarikat dengan tahap pengumpulan orang dalam yang paling tinggi. Model pemarkahan menggunakan gabungan bilangan bersih orang dalam yang membeli 90 hari sebelumnya, jumlah saham yang dibeli sebagai peratusan saham beredar, dan jumlah saham yang dimiliki oleh orang dalam. Nombor ini berjulat dari 0 hingga 100, dengan nombor yang lebih tinggi menunjukkan tahap pengumpulan yang lebih tinggi kepada rakannya, dan 50 adalah purata.

Kekerapan Kemas Kini: Harian

Lihat Pilihan Teratas Orang Dalam, yang menyediakan senarai syarikat dengan pengumpulan orang dalam tertinggi.

Lihat Saham Kedudukan Tertinggi

Skor Sentimen Pegawai

Skor Sentimen Pegawai mendapati syarikat dibeli oleh Pegawai Korporat.

Mengikut definisi Pegawai Korporat ialah Orang Dalam Korporat, tetapi tidak seperti beberapa Orang Dalam yang lain (10% Pemegang Saham dan Ahli Lembaga), Pegawai bekerja untuk syarikat tersebut setiap hari, dan mereka menggunakan wang mereka sendiri semasa berdagang . (10% Pemegang Saham dan Ahli Lembaga Pengarah selalunya pengurus dana yang menguruskan wang orang lain.) Oleh itu, dagangan orang dalam yang dibuat oleh Pegawai adalah lebih penting dan harus dilayan dengan sewajarnya.

Seperti Skor Sentimen Orang Dalam, Skor Sentimen Pegawai adalah hasil daripada model kuantitatif berbilang faktor yang canggih yang mengenal pasti syarikat yang mempunyai tahap pengumpulan pegawai tertinggi.

Kekerapan Kemas Kini: Harian

Lihat Pilihan Teratas Orang Dalam, yang menyediakan senarai syarikat yang mempunyai sentimen orang dalam tertinggi.

Lihat Saham Kedudukan Tertinggi

Metrik Orang Dalam Utama

Kad ini menunjukkan bagaimana kedudukan syarikat mengikut pelbagai metrik orang dalam. Kedudukan persentil menunjukkan cara syarikat ini dibandingkan dengan syarikat lain di pasaran AS. Kedudukan yang lebih tinggi menunjukkan keadaan yang lebih baik.

Sebagai contoh, adalah diterima umum bahawa pembelian orang dalam ialah penunjuk positif, jadi syarikat yang mempunyai lebih banyak pembelian orang dalam akan mendapat kedudukan lebih tinggi daripada syarikat yang kurang pembelian orang dalam (atau malah jualan orang dalam).

Bilangan Bersih Pembelian Orang Dalam (Kedudukan)

-4 ( )

10922 out of 11323

Bilangan Bersih Pembelian Orang Dalam ialah jumlah bilangan orang dalam yang membeli tolak jumlah orang dalam yang menjual dalam tempoh 90 hari terakhir. Kedudukan persentil ditunjukkan di sini (julat dari 0 hingga 100%).

Peratusan Saham Beredar yang Dibeli oleh Orang Dalam (Kedudukan)

N/A

Peratusan Saham Beredar yang Dibeli oleh Orang Dalam ialah jumlah bilangan saham yang dibeli oleh orang dalam tolak jumlah bilangan saham yang dijual oleh orang dalam dalam tempoh 90 hari terakhir, dibahagikan dengan jumlah saham beredar dan didarab dengan 100.

Carta Dagangan Dalaman

Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock) dagangan dalaman ditunjukkan dalam carta berikut. Orang dalam ialah pegawai, pengarah atau pelabur penting dalam syarikat. Secara umumnya adalah menyalahi undang-undang bagi orang dalam untuk membuat perdagangan dalam syarikat mereka berdasarkan maklumat material dan bukan awam. Ini tidak bermakna haram untuk mereka membuat sebarang perdagangan dalam syarikat mereka sendiri. Walau bagaimanapun, mereka mesti melaporkan semua dagangan kepada SEC melalui Borang 4.

Senarai Orang Dalam dan Metrik Keberuntungan

Jadual ini menunjukkan senarai orang dalam yang diketahui dan dijana secara automatik daripada pemfailan yang didedahkan kepada SEC. Sebagai tambahan kepada nama, gelaran terkini dan pengarah, pegawai, atau 10% jawatan pemilik, kami menyediakan pegangan yang didedahkan terkini. Selain itu, apabila boleh, kami menyediakan sejarah prestasi perdagangan untuk orang dalam. Sejarah prestasi perdagangan ialah purata wajaran prestasi transaksi pembelian pasaran terbuka sebenar yang dibuat oleh orang dalam. Untuk mendapatkan maklumat lanjut tentang cara ini dikira, tonton webinar YouTube ini.

See our leaderboard of most profitable insider traders.

Orang dalam	Saham Dimiliki	Berpecah Dilaraskan
Lawrence M Alleva Director - [D]	12,600	12,600
Rafael Amado President, R&D - [O]	17,237	17,237
M James Barrett 10% Owner - [10%]	82,978,668	82,978,668
Peter J Barris 10% Owner - [10%]	12,000,000	12,000,000
Forest Baskett 10% Owner - [10%]	19,500,000	19,500,000
Ali Behbahani Director - [D]	0	0
William C JR Bertrand Chief Operating Officer - [O]	986,352	986,352
Gwendolyn Knowlton Binder-Scholl Chief Technology Officer - [O]	2,487	2,487
Joanna Elizabeth Brewer	223,512
Barbara Gayle Duncan	144,000
EcoR1 Capital, LLC 10% Owner - [10%]	100,371,882	100,371,882
Florence Anthony A. Jr. 10% Owner - [10%]	19,500,000	19,500,000
John Furey	196,186

Orang dalam	Saham Dimiliki	Berpecah Dilaraskan
Michael Garone	0
Samuel D Isaly Director - [D]	6,149,377	6,149,377
Patrick J Kerins 10% Owner - [10%]	82,978,668	82,978,668
Krishna Kittu Kolluri 10% Owner - [10%]	118,538,000	118,538,000
Giles Francis Bertram Kerr	124,000
Jonathan Kenneth Charles Knowles Director - [D]	7,208,768	7,208,768
Ian Michael Laing Director - [D]	58,085,600	58,085,600
John Lunger Chief Patient Supply Officer - [O]	7,510	7,510
David M Mott Director, 10% Owner - [D] [10%]	19,500,000	19,500,000
Garry E Menzel Director - [D]	75,056	75,056
Nea 14 Gp, Ltd 10% Owner - [10%]	82,978,668	82,978,668
NEA Partners 14, L.P. 10% Owner - [10%]	82,978,668	82,978,668
New Enterprise Associates 14, L.P. 10% Owner - [10%]	82,978,668	82,978,668
James Noble Director - [D]	0	0

Orang dalam	Saham Dimiliki	Berpecah Dilaraskan
Elliot Norry Chief Medical Officer - [O]	7,510	7,510
Orbimed Advisors Llc Director - [D]	4,901,310	4,901,310
OrbiMed Capital GP V LLC Director - [D]	4,901,310	4,901,310
Cintia Piccina Chief Commercial Officer - [O]	18,421	18,421
Adrian Rawcliffe Chief Executive Officer, Director - [D] [O]	44,327	44,327
Scott D Sandell 10% Owner - [10%]	19,500,000	19,500,000
Charles Elliott Sigal Director - [D]	314,100	314,100
Sonsini Peter W. 10% Owner - [10%]	19,500,000	19,500,000
Helen Katrina Tayton-martin Chief Business Officer - [O]	1,800,000	1,800,000
Thompson Peter A. Director - [D]	4,901,310	4,901,310
Ravi Viswanathan 10% Owner - [10%]	12,000,000	12,000,000
Harry R Weller 10% Owner - [10%]	118,538,000	118,538,000
Gavin Wood Chief Financial Officer - [O]	0	0
Tal Zvi Zaks	144,000

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Rekod Jejak Pembelian Orang Dalam - Analisis Keuntungan Jangka Pendek

Dalam bahagian ini, kami menganalisis keuntungan setiap pembelian orang dalam pasaran terbuka yang tidak dirancang yang dibuat dalam ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). Analisis ini membantu untuk memahami sama ada orang dalam secara konsisten menjana pulangan tidak normal dan patut diikuti. Analisis ini adalah untuk satu tahun selepas setiap perdagangan, dan hasilnya adalah bersifat teori .

Jadual berikut menunjukkan pembelian pasaran terbuka terkini yang bukan sebahagian daripada pelan dagangan automatik.

Tarikh Dagangan	Orang dalam	Dilaporkan Saham	Dilaporkan harga	Dilaraskan Saham	Dilaraskan harga	Asas Kos	Hari ke Maks	Harga pada Maks	Maks Keuntungan ($)	Pulangan Maks (%)
2022-05-20	Wood Gavin	39,000	0.2904	39,000	0.2904	11,326	185	2.5300	87,345	771.26
2021-06-01	Alleva Lawrence M	12,600	0.7900	12,600	0.7900	9,954
2020-12-14	Bertrand William C JR	207,000	0.6948	207,000	0.6948	143,824
2020-12-14	Wood Gavin	24,000	0.6896	24,000	0.6896	16,550
2020-06-29	Wood Gavin	33,000	1.6200	33,000	1.6200	53,460
2020-06-09	Alleva Lawrence M	12,900	1.8900	12,900	1.8900	24,381
2020-01-24	Sonsini Peter W.	7,500,000	0.6667	7,500,000	0.6667	5,000,250
2018-12-17	Alleva Lawrence M	47,280	0.8400	47,280	0.8400	39,715
2018-09-07	Viswanathan Ravi	12,000,000	1.6667	12,000,000	1.6667	20,000,400

Harga Larasan ialah harga larasan berpecah. Saham Larasan ialah saham terlaras pecah.

ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock) Insider Trades

Rekod Jejak Jualan Orang Dalam - Analisis Kerugian Jangka Pendek

Dalam bahagian ini, kami menganalisis pengelakan kerugian jangka pendek bagi setiap jualan dalaman pasaran terbuka yang tidak dirancang yang dibuat dalam ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). Corak pengelakan kerugian yang konsisten mungkin mencadangkan bahawa urus niaga jualan masa hadapan mungkin meramalkan penurunan harga. Analisis ini adalah untuk satu tahun selepas setiap perdagangan, dan hasilnya adalah bersifat teori .

Jadual berikut menunjukkan jualan pasaran terbuka terkini yang bukan sebahagian daripada pelan dagangan automatik.

Tarikh Dagangan	Orang dalam	Dilaporkan Saham	Dilaporkan harga	Dilaraskan Saham	Dilaraskan harga	Asas Kos	Hari ke Min	Harga pada Min	Kerugian Maks Dielakkan ($)	Kerugian Maks Dielakkan (%)
2025-09-02	Wood Gavin	96,000	0.0099	96,000	0.0099	950	3	0.0409	2,976	313.31
2025-08-28	Bertrand William C JR	207,000	0.0101	207,000	0.0101	2,091
2025-08-18	Behbahani Ali	14,671,794	0.0120	14,671,794	0.0120	176,062
2025-08-15	Behbahani Ali	4,828,206	0.0110	4,828,206	0.0110	53,110
2025-07-30	EcoR1 Capital, LLC	27,433,338	0.1021	27,433,338	0.1021	2,800,944
2025-07-29	EcoR1 Capital, LLC	2,687,460	0.1012	2,687,460	0.1012	271,971
2025-07-28	EcoR1 Capital, LLC	33,931,740	0.1125	33,931,740	0.1125	3,817,321
2025-01-17	Rawcliffe Adrian	30,601	0.5808	30,601	0.5808	17,773
2025-01-17	Norry Elliot	5,584	0.5808	5,584	0.5808	3,243

Harga Larasan ialah harga larasan berpecah. Saham Larasan ialah saham terlaras pecah.

Sejarah Transaksi

Klik ikon pautan untuk melihat sejarah transaksi penuh. Transaksi yang dilaporkan sebagai sebahagian daripada pelan dagangan automatik 10b5-1 akan mempunyai X dalam lajur bertanda 10b-5.

Fail Tarikh	Dagangan Tarikh	Borang	Orang dalam	Simbol Saham	Nama Sekuriti	Kod	Langsung	Harga Pelaksanaan	Harga Unit	Unit Berubah	Nilai Berubah (1K)	Baki Opsyen	Baki Saham
2025-09-03	2025-09-02	4	Wood Gavin	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	S - Sale	D		0.0099	-96,000	-1		0
2025-08-29	2025-08-28	4	Bertrand William C JR	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	S - Sale	D		0.0101	-207,000	-2		986,352
2025-08-19	2025-08-18	4	Behbahani Ali See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	S - Sale	I		0.0120	-14,671,794	-176		0
2025-08-19	2025-08-15	4	Behbahani Ali See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	S - Sale	I		0.0110	-4,828,206	-53		14,671,794
2025-07-30	2025-07-30	4	EcoR1 Capital, LLC See Note	ADAP	Ordinary Shares	S - Sale	I		0.1021	-27,433,338	-2,801		100,371,882
2025-07-30	2025-07-29	4	EcoR1 Capital, LLC See Note	ADAP	Ordinary Shares	S - Sale	I		0.1012	-2,687,460	-272		127,805,220
2025-07-30	2025-07-28	4	EcoR1 Capital, LLC See Note	ADAP	Ordinary Shares	S - Sale	I		0.1125	-33,931,740	-3,817		130,492,680
2025-01-17	2025-01-17	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5808	-5,584	-3		7,510
2025-01-17	2025-01-17	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5808	-5,584	-3		7,510
2025-01-17	2025-01-17	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5808	-5,584	-3		7,510
2025-01-17	2025-01-17	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5808	-30,601	-18		44,327
2025-01-15	2025-01-15	4	Piccina Cintia	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5748	-12,991	-7		18,421
2025-01-15	2025-01-15	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5748	-29,096	-17		41,582
2025-01-15	2025-01-13	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-17,934	-11		25,711
2025-01-15	2025-01-13	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-12,539	-7		17,801
2025-01-15	2025-01-15	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5748	-9,803	-6		13,756
2025-01-15	2025-01-13	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-8,124	-5		11,516
2025-01-15	2025-01-13	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-4,268	-3		5,845
2025-01-15	2025-01-15	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5748	-9,803	-6		13,756
2025-01-15	2025-01-13	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-5,471	-3		7,623
2025-01-15	2025-01-13	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-4,268	-3		5,845
2025-01-15	2025-01-15	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5748	-9,803	-6		13,756
2025-01-15	2025-01-13	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-5,471	-3		7,623
2025-01-15	2025-01-13	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.5879	-4,268	-3		5,845
2024-06-18	2024-06-18	4	Piccina Cintia	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.9300	-24,531	-23		38,293
2024-03-26		3	EcoR1 Capital, LLC See Note	ADAP	Ordinary Shares		I						164,424,420
2024-01-17	2024-01-17	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.6730	-30,080	-20		44,848
2024-01-17	2024-01-16	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.7900	-9,304	-7		14,104
2024-01-17	2024-01-17	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.6730	-12,967	-9		19,257
2024-01-17	2024-01-17	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.6730	-5,309	-4		7,785
2024-01-17	2024-01-16	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.7900	-2,287	-2		3,363
2024-01-17	2024-01-17	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.6730	-12,805	-9		19,015
2024-01-17	2024-01-17	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.6730	-5,309	-4		7,785
2024-01-17	2024-01-16	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.7900	-4,681	-4		7,023
2024-01-17	2024-01-17	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.6730	-13,599	-9		20,201
2024-01-17	2024-01-17	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.6730	-5,309	-4		7,785
2024-01-17	2024-01-16	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.7900	-4,681	-4		7,023
2024-01-12	2024-01-12	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8541	-5,220	-4		7,874
2024-01-12	2024-01-11	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8367	-4,009	-3		6,104
2024-01-12	2024-01-12	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8541	-17,257	-15		26,388
2024-01-12	2024-01-11	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8367	-11,945	-10		18,395
2024-01-12	2024-01-12	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8541	-5,220	-4		7,874
2024-01-12	2024-01-11	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8367	-4,009	-3		6,104
2024-01-12	2024-01-12	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8541	-7,799	-7		11,841
2024-01-12	2024-01-11	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.8367	-4,009	-3		6,104
2023-09-01	2023-09-01	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.7800	-2,403	-2		3,449
2023-08-01	2023-08-01	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.9056	-3,096	-3		4,718
2023-07-10	2023-07-10	4	Menzel Garry E	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.9108	-47,702	-43		75,056
2023-06-27	2023-06-27	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		0.9200	-2,333	-2		3,519
2023-06-01	2023-06-01	4	Menzel Garry E	ADAP	American Depositary Shares representing Ordinary Shares	A - Award	D			209,931			209,931
2023-06-01	2023-06-01	4	Menzel Garry E	ADAP	American Depositary Shares representing Ordinary Shares	A - Award	I			200,647			200,647
2023-06-01	2023-06-01	4	Menzel Garry E	ADAP	American Depositary Shares representing Ordinary Shares	A - Award	I			200,646			200,646
2023-01-31	2023-01-31	4	Piccina Cintia	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.8696	-11,890	-22		19,535
2023-01-17	2023-01-17	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.8580	-4,440	-8		7,264
2023-01-17	2023-01-17	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.8580	-10,057	-19		13,351
2023-01-17	2023-01-17	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.8580	-4,440	-8		7,264
2023-01-17	2023-01-17	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.8580	-2,159	-4		3,491
2023-01-12	2023-01-12	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7060	-4,973	-8		8,121
2023-01-12	2023-01-11	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7468	-3,843	-7		6,270
2023-01-12	2023-01-12	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7060	-4,973	-8		8,121
2023-01-12	2023-01-11	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7468	-3,843	-7		6,270
2023-01-12	2023-01-12	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7060	-7,449	-13		12,191
2023-01-12	2023-01-11	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7468	-3,843	-7		6,270
2023-01-12	2023-01-12	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7060	-18,763	-32		24,882
2023-01-12	2023-01-11	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7468	-13,042	-23		17,298
2023-01-04	2023-01-04	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.6940	-3,584	-6		5,781
2023-01-04	2023-01-04	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.6940	-5,073	-9		6,631
2023-01-04	2023-01-04	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.6940	-876	-1		1,361
2023-01-04	2023-01-04	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.6940	-1,100	-2		1,725
2022-09-01	2022-09-01	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.9689	-2,536	-5		3,316
2022-08-01	2022-08-01	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7735	-2,983	-5		4,829
2022-08-01	2022-08-01	4	Piccina Cintia	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.7735	-21,040	-37		34,824
2022-07-05	2022-07-05	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.6781	-1,973	-3		3,104
2022-06-27	2022-06-27	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.6300	-2,562	-4		3,290
2022-05-23	2022-05-20	4	Wood Gavin	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	D		0.2904	39,000	11		96,000
2022-05-04	2022-05-04	4	Brewer Joanna Elizabeth	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		223,512		223,512
2022-05-04	2022-05-04	4	Brewer Joanna Elizabeth	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.30		333,792		333,792
2022-01-31	2022-01-31	4	Piccina Cintia	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		335,184		335,184
2022-01-31	2022-01-31	4	Piccina Cintia	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		754,200		754,200
2022-01-31	2022-01-31	4	Piccina Cintia	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.45		3,376,992		3,376,992
2022-01-18	2022-01-18	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.1918	-4,368	-14		7,336
2022-01-18	2022-01-18	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.1918	-4,368	-14		7,336
2022-01-18	2022-01-18	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.1918	-2,121	-7		3,529
2022-01-18	2022-01-18	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.1918	-11,096	-35		12,312
2022-01-13	2022-01-12	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		314,256		314,256
2022-01-13	2022-01-12	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.60		1,407,072		1,407,072
2022-01-13	2022-01-12	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		314,256		314,256
2022-01-13	2022-01-12	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.60		1,407,072		1,407,072
2022-01-13	2022-01-12	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5441	-2,248	-8		3,754
2022-01-13	2022-01-11	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5567	-3,770	-13		6,343
2022-01-13	2022-01-12	4	Wood Gavin	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		314,256		314,256
2022-01-13	2022-01-12	4	Wood Gavin	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.60		1,407,072		1,407,072
2022-01-13	2022-01-12	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5441	-1,076	-4		1,749
2022-01-13	2022-01-11	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5567	-3,770	-13		6,343
2022-01-13	2022-01-12	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5441	-854	-3		1,383
2022-01-13	2022-01-11	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5567	-3,770	-13		6,343
2022-01-13	2022-01-12	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5441	-3,046	-11		3,356
2022-01-13	2022-01-11	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5567	-14,362	-51		15,978
2022-01-13	2022-01-12	4	Norry Elliot	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		471,360		471,360
2022-01-13	2022-01-12	4	Norry Elliot	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.60		2,110,608		2,110,608
2022-01-13	2022-01-12	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		1,047,480		1,047,480
2022-01-13	2022-01-12	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.60		4,690,224		4,690,224
2022-01-13	2022-01-12	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		314,256		314,256
2022-01-13	2022-01-12	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.60		1,407,072		1,407,072
2022-01-05	2022-01-04	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		4.0642	-3,490	-14		5,873
2022-01-05	2022-01-04	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		4.0642	-1,070	-4		1,755
2022-01-05	2022-01-04	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		4.0642	-849	-3		1,388
2022-01-05	2022-01-04	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		4.0642	-5,532	-22		6,172
2021-09-01	2021-09-01	4	Rawcliffe Adrian	ADAP]	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.1950	-2,782	-14		3,070
2021-08-02	2021-08-02	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		3.5848	-2,939	-11		4,873
2021-07-02	2021-07-01	4	Duncan Barbara Gayle	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		379,788		379,788
2021-07-02	2021-07-01	4	Alleva Lawrence M	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		505,918		505,918
2021-07-02	2021-07-01	4	Behbahani Ali	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		474,385		474,385
2021-07-02	2021-07-01	4	Sigal Charles Elliott	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		474,385		474,385
2021-07-02	2021-07-01	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		379,788		379,788
2021-07-02	2021-07-02	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		4.2649	-4,375	-19		7,329
2021-07-02	2021-07-01	4	MOTT DAVID M	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		579,494		579,494
2021-07-02	2021-07-01	4	Zaks Tal Zvi	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		379,788		379,788
2021-07-02	2021-07-01	4	Furey John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.71		379,788		379,788
2021-07-02	2021-07-02	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		4.2649	-1,907	-8		3,170
2021-06-28	2021-06-28	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		4.3700	-2,794	-12		3,058
2021-06-03	2021-06-01	4	Alleva Lawrence M Held by Trust	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		0.7900	12,600	10		12,600
2021-03-03	2021-03-03	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	M - Exercise	D		0.1570	1,785,000	280		1,800,000
2021-01-19	2021-01-19	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.6695	-2,111	-12		3,539
2021-01-19	2021-01-19	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.6695	-4,358	-25		7,346
2021-01-19	2021-01-19	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.6695	-9,879	-56		13,529
2021-01-12	2021-01-12	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		6.1522	-2,234	-14		3,768
2021-01-12	2021-01-12	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		6.1522	-1,058	-7		1,767
2021-01-12	2021-01-12	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		6.1522	-841	-5		1,396
2021-01-12	2021-01-12	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		6.1522	-2,707	-17		3,695
2021-01-11	2021-01-11	4	Wood Gavin	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		242,712		242,712
2021-01-11	2021-01-11	4	Wood Gavin	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.03		1,086,816		1,086,816
2021-01-11	2021-01-11	4	Norry Elliot	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		242,712		242,712
2021-01-11	2021-01-11	4	Norry Elliot	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.03		1,086,816		1,086,816
2021-01-11	2021-01-11	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		728,160		728,160
2021-01-11	2021-01-11	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.03		3,260,400		3,260,400
2021-01-11	2021-01-11	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		242,712		242,712
2021-01-11	2021-01-11	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.03		1,086,816		1,086,816
2021-01-11	2021-01-11	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		242,712		242,712
2021-01-11	2021-01-11	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.03		1,086,816		1,086,816
2021-01-11	2021-01-11	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		242,712		242,712
2021-01-11	2021-01-11	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.03		1,086,816		1,086,816
2021-01-05	2021-01-04	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3279	-1,065	-6		1,760
2021-01-05	2021-01-04	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3279	-845	-5		1,392
2021-01-05	2021-01-04	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3279	-3,499	-19		5,864
2021-01-05	2021-01-04	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3279	-4,967	-26		6,737
2020-12-16	2020-12-14	4	Wood Gavin	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	D		0.6896	24,000	17		57,000
2020-12-15	2020-12-14	4	Bertrand William C JR	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	D		0.6948	207,000	144		284,808
2020-09-02	2020-09-01	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		8.5149	-2,776	-24		3,076
2020-08-04	2020-08-03	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		9.2500	-2,788	-26		3,064
2020-08-04	2020-08-03	4	TAYTON-MARTIN HELEN KATRINA	ADAP	American Depositary Shares	S - Sale	D		8.7409	-200,000	-1,748		0
2020-08-04	2020-08-03	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		9.2500	-4,823	-45		8,066
2020-07-01	2020-07-01	4	Behbahani Ali	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		184,258		184,258
2020-07-01	2020-07-01	4	Furey John	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		196,186		196,186
2020-07-01	2020-07-01	4	Alleva Lawrence M	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		197,678		197,678
2020-07-01	2020-07-01	4	Zaks Tal Zvi	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		144,000		144,000
2020-07-01	2020-07-01	4	Duncan Barbara Gayle	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		144,000		144,000
2020-07-01	2020-07-01	4	MOTT DAVID M	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		226,753		226,753
2020-07-01	2020-07-01	4	Sigal Charles Elliott	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		184,258		184,258
2020-07-01	2020-07-01	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.67		179,785		179,785
2020-06-30	2020-06-29	4	Wood Gavin	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	D		1.6200	33,000	53		33,000
2020-06-11	2020-06-09	4	Alleva Lawrence M Held by Trust	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		1.8900	12,900	24		12,900
2020-06-02	2020-05-29	4	Noble James	ADAP	American Depositary Shares	S - Sale	D		9.3320	-500,000	-4,666		0
2020-04-01	2020-04-01	4	Wood Gavin	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		565,000		565,000
2020-04-01	2020-04-01	4	Wood Gavin	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.45		2,500,000		2,500,000
2020-04-01	2020-04-01	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.45		31,000		31,000
2020-01-28	2020-01-24	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.6667	7,500,000	5,000		19,500,000
2020-01-28	2020-01-24	4	Behbahani Ali See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.6667	7,500,000	5,000		19,500,000
2020-01-28	2020-01-24	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.6667	7,500,000	5,000		19,500,000
2020-01-28	2020-01-24	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.6667	7,500,000	5,000		19,500,000
2020-01-28	2020-01-24	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.6667	7,500,000	5,000		19,500,000
2020-01-28	2020-01-24	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.6667	7,500,000	5,000		19,500,000
2020-01-17	2020-01-16	4	Norry Elliot	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		135,600		135,600
2020-01-17	2020-01-16	4	Norry Elliot	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.74		201,600		201,600
2020-01-17	2020-01-16	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		280,896		280,896
2020-01-17	2020-01-16	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.74		1,257,744		1,257,744
2020-01-17	2020-01-16	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		280,896		280,896
2020-01-17	2020-01-16	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.74		1,257,744		1,257,744
2020-01-17	2020-01-16	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		561,792		561,792
2020-01-17	2020-01-16	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.74		2,515,536		2,515,536
2020-01-17	2020-01-16	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		280,896		280,896
2020-01-17	2020-01-16	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.74		1,257,744		1,257,744
2020-01-15	2020-01-13	4	Noble James	ADAP	American Depositary Shares	S - Sale	D		5.0000	-200,000	-1,000		0
2020-01-15	2020-01-13	4	Noble James	ADAP	American Depositary Shares	S - Sale	D		4.0000	-100,000	-400		0
2020-01-15	2020-01-14	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.1347	-3,236	-17		3,166
2020-01-15	2020-01-14	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.1347	-1,144	-6		1,681
2020-01-15	2020-01-13	4	TAYTON-MARTIN HELEN KATRINA	ADAP	American Depositary Shares	S - Sale	D		5.0000	-50,000	-250		0
2020-01-15	2020-01-13	4	TAYTON-MARTIN HELEN KATRINA	ADAP	American Depositary Shares	S - Sale	D		4.0000	-50,000	-200		0
2020-01-15	2020-01-14	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.1347	-2,397	-12		3,605
2020-01-15	2020-01-14	4	Norry Elliot	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.1347	-911	-5		1,326
2020-01-13		3	Norry Elliot	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						5,358
2020-01-13		3	Norry Elliot	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						5,358
2020-01-13		3	Norry Elliot	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						5,358
2020-01-07	2020-01-06	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.2000	-5,900	-7		5,804
2020-01-07	2020-01-06	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.2000	-3,731	-4		5,632
2020-01-07	2020-01-06	4	Lunger John	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		1.2000	-1,148	-1		1,677
2019-09-03	2019-09-01	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		140,448		140,448
2019-09-03	2019-09-01	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.27		628,872		628,872
2019-08-07	2019-08-06	4	Amado Rafael	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		2.0600	-11,043	-23		17,237
2019-08-05		3	Lunger John	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						57,612
2019-08-05		3	Lunger John	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						57,612
2019-08-05		3	Lunger John	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						57,612
2019-08-05	2019-08-01	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		187,500		187,500
2019-08-05	2019-08-01	4	Lunger John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.55		839,568		839,568
2019-07-03	2019-07-02	4	Behbahani Ali	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		234,407		234,407
2019-07-03	2019-07-02	4	MOTT DAVID M	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		350,947		350,947
2019-07-03	2019-07-02	4	Alleva Lawrence M	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		271,209		271,209
2019-07-03	2019-07-02	4	Duncan Barbara Gayle	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		124,000		124,000
2019-07-03	2019-07-02	4	Sigal Charles Elliott	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		234,407		234,407
2019-07-03	2019-07-02	4	Kerr Giles Francis Bertram	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		124,000		124,000
2019-07-03	2019-07-02	4	Furey John	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		240,541		240,541
2019-07-03	2019-07-02	4	Zaks Tal Zvi	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.61		124,000		124,000
2019-06-27	2019-06-27	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		140,448		140,448
2019-06-27	2019-06-27	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.68		628,872		628,872
2019-05-17	2019-05-16	4	Noble James	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	M - Exercise	D		0.1430	1,773,100	254		1,773,100
2019-01-16	2019-01-14	4	Rawcliffe Adrian	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3694	-3,084	-17		3,318
2019-01-16	2019-01-14	4	Amado Rafael	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3694	-3,028	-16		4,974
2019-01-16	2019-01-14	4	Bertrand William C JR	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3694	-2,271	-12		3,731
2019-01-16	2019-01-14	4	Binder-Scholl Gwendolyn Knowlton	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	D		5.3694	-1,514	-8		2,487
2019-01-08	2019-01-04	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		561,792		561,792
2019-01-08	2019-01-04	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.89		2,515,536		2,515,536
2019-01-08	2019-01-04	4	Amado Rafael	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		224,724		224,724
2019-01-08	2019-01-04	4	Amado Rafael	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.89		1,006,224		1,006,224
2019-01-08	2019-01-04	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		280,896		280,896
2019-01-08	2019-01-04	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.89		1,257,744		1,257,744
2019-01-08	2019-01-04	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		224,724		224,724
2019-01-08	2019-01-04	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.89		1,006,224		1,006,224
2019-01-08	2019-01-04	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		224,724		224,724
2019-01-08	2019-01-04	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.89		1,006,224		1,006,224
2018-12-19	2018-12-17	4	Alleva Lawrence M Held by Trust	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		0.8400	47,280	40		47,280
2018-10-02	2018-10-01	4	Binder-Scholl Gwendolyn Knowlton	ADAP	American Depositary Shares	S - Sale	D		13.7900	-25,000	-345		0
2018-09-10	2018-09-07	4	New Enterprise Associates 14, L.P.	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	D		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	BARRETT M JAMES See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	BARRIS PETER J See Note 5	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	BARRIS PETER J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	BASKETT FOREST See Note 5	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	Behbahani Ali See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	Florence Anthony A. Jr. See Note 5	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	KERINS PATRICK J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	MOTT DAVID M See Note 5	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	SANDELL SCOTT D See Note 5	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	Sonsini Peter W. See Note 5	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-09-10	2018-09-07	4	Viswanathan Ravi See Note 5	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	12,000,000	20,000		12,000,000
2018-09-10	2018-09-07	4	Viswanathan Ravi See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.6667	3,000,000	5,000		82,978,668
2018-08-31	2018-08-29	4	Binder-Scholl Gwendolyn Knowlton	ADAP	American Depositary Shares	S - Sale	D		10.2500	-25,000	-256		0
2018-08-07	2018-08-06	4	Amado Rafael	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		678,720		678,720
2018-06-26	2018-06-22	4	Sigal Charles Elliott	ADAP	Option to purchase Ordinary Shares	A - Award	D	2.18		154,809		154,809
2018-06-26	2018-06-22	4	Duncan Barbara Gayle	ADAP	Option to purchase Ordinary Shares	A - Award	D	2.18		158,233		158,233
2018-06-26	2018-06-22	4	Kerr Giles Francis Bertram	ADAP	Option to purchase Ordinary Shares	A - Award	D	2.18		124,000		124,000
2018-06-26	2018-06-22	4	Alleva Lawrence M	ADAP	Option to purchase Ordinary Shares	A - Award	D	2.18		124,000		124,000
2018-06-26	2018-06-22	4	Zaks Tal Zvi	ADAP	Option to purchase Ordinary Shares	A - Award	D	2.18		124,000		124,000
2018-06-26	2018-06-22	4	Behbahani Ali	ADAP	Option to purchase Ordinary Shares	A - Award	D	2.18		154,809		154,809
2018-06-26	2018-06-22	4	MOTT DAVID M	ADAP	Option to purchase Ordinary Shares	A - Award	D	2.18		187,330		187,330
2018-06-06	2018-06-06	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.4900	-1,600	-22		4,901,310
2018-06-06	2018-06-04	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.5700	-17,100	-232		4,902,910
2018-06-06	2018-06-06	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.4900	-1,600	-22		4,901,310
2018-06-06	2018-06-04	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.5700	-17,100	-232		4,902,910
2018-06-01	2018-06-01	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.4900	-50,000	-674		4,920,010
2018-06-01	2018-05-30	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.5200	-121,000	-1,636		4,970,010
2018-06-01	2018-06-01	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.4900	-50,000	-674		4,920,010
2018-06-01	2018-05-30	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.5200	-121,000	-1,636		4,970,010
2018-05-16	2018-05-14	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.5000	-10,300	-139		5,091,010
2018-05-16	2018-05-14	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		13.5000	-10,300	-139		5,091,010
2018-03-29	2018-03-29	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		11.5300	-31,983	-369		5,101,310
2018-03-29	2018-03-27	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		11.5000	-1,016,084	-11,685		5,133,293
2018-03-29	2018-03-29	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		11.5300	-31,983	-369		5,101,310
2018-03-29	2018-03-27	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	S - Sale	I		11.5000	-1,016,084	-11,685		5,133,293
2018-03-28	2018-03-27	4	KERINS PATRICK J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	KERINS PATRICK J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	Viswanathan Ravi See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	Viswanathan Ravi See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	New Enterprise Associates 14, L.P.	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	D		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	New Enterprise Associates 14, L.P.	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	D		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	BARRETT M JAMES See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	BARRETT M JAMES See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	BARRIS PETER J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	BARRIS PETER J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-28	2018-03-27	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9167	6,000,000	11,500		79,978,672
2018-03-28	2018-03-26	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9041	571,164	1,088		73,978,672
2018-03-23	2018-03-23	4	New Enterprise Associates 14, L.P.	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	D		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	New Enterprise Associates 14, L.P.	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	D		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	New Enterprise Associates 14, L.P.	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	D		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	BARRETT M JAMES See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	BARRETT M JAMES See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	BARRETT M JAMES See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	BARRIS PETER J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	BARRIS PETER J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	BARRIS PETER J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	KERINS PATRICK J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	KERINS PATRICK J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	KERINS PATRICK J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-23	2018-03-23	4	Viswanathan Ravi See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9462	294,090	572		73,407,508
2018-03-23	2018-03-22	4	Viswanathan Ravi See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.9040	869,574	1,656		73,113,418
2018-03-23	2018-03-21	4	Viswanathan Ravi See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		1.8105	104,844	190		72,243,844
2018-03-22	2018-03-20	4	Rawcliffe Adrian	ADAP	Ordinary Shares	S - Sale	D		1.7100	-600,000	-1,026		0
2018-01-17	2018-01-12	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		384,120		384,120
2018-01-17	2018-01-12	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.30		1,719,936		1,719,936
2018-01-17	2018-01-12	4	Amado Rafael	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		192,060		192,060
2018-01-17	2018-01-12	4	Amado Rafael	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.30		859,968		859,968
2018-01-17	2018-01-12	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		144,048		144,048
2018-01-17	2018-01-12	4	Bertrand William C JR	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.30		644,976		644,976
2018-01-17	2018-01-12	4	Binder-Scholl Gwendolyn Knowlton	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		96,036		96,036
2018-01-17	2018-01-12	4	Binder-Scholl Gwendolyn Knowlton	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.30		429,984		429,984
2018-01-17	2018-01-12	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		153,648		153,648
2018-01-17	2018-01-12	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.30		687,984		687,984
2018-01-17	2018-01-12	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.00		153,648		153,648
2018-01-17	2018-01-12	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.30		687,984		687,984
2017-07-03	2017-07-03	4	Zaks Tal Zvi	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		144,000		144,000
2017-07-03	2017-07-03	4	Duncan Barbara Gayle	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		228,765		228,765
2017-07-03	2017-07-03	4	Behbahani Ali	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		220,788		220,788
2017-07-03	2017-07-03	4	MOTT DAVID M	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		302,561		302,561
2017-07-03	2017-07-03	4	Alleva Lawrence M	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		243,724		243,724
2017-07-03	2017-07-03	4	Kerr Giles Francis Bertram	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		144,000		144,000
2017-07-03	2017-07-03	4	Sigal Charles Elliott	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		220,788		220,788
2017-07-03	2017-07-03	4	Thompson Peter A.	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.75		223,779		223,779
2017-03-28	2017-03-27	4	Thompson Peter A. See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	P - Purchase	I		4.2000	1,190,476	5,000		6,149,377
2017-03-28	2017-03-27	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	American Depositary Shares representing Ordinary Shares	P - Purchase	I		4.2000	1,190,476	5,000		6,149,377
2017-03-28	2017-03-27	4	KERINS PATRICK J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	MOTT DAVID M See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	SANDELL SCOTT D See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	Sonsini Peter W. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	Viswanathan Ravi See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	New Enterprise Associates 14, L.P.	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	D		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	BARRETT M JAMES See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	BARRIS PETER J See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	BASKETT FOREST See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-03-28	2017-03-27	4	Florence Anthony A. Jr. See Note 3	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share	P - Purchase	I		0.7000	12,870,000	9,009		72,139,000
2017-01-18	2017-01-13	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.72		2,072,976		2,072,976
2017-01-18	2017-01-13	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.72		2,072,976		2,072,976
2017-01-18	2017-01-13	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.72		2,072,976		2,072,976
2017-01-18	2017-01-13	4	Binder-Scholl Gwendolyn Knowlton	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.72		2,072,976		2,072,976
2017-01-18	2017-01-13	4	Amado Rafael	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.72		2,072,976		2,072,976
2016-12-01	2016-11-29	4	Kerr Giles Francis Bertram	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.81		288,000		288,000
2016-12-01	2016-11-29	4	Zaks Tal Zvi	ADAP	Option to purchase Ordinary Shares	A - Award	D	0.81		288,000		288,000
2016-08-12	2016-08-11	4	Thompson Peter A.	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		186,142		186,142
2016-08-12	2016-08-11	4	Alleva Lawrence M	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		196,678		196,678
2016-08-12	2016-08-11	4	Behbahani Ali	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		184,562		184,562
2016-08-12	2016-08-11	4	MOTT DAVID M	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		191,410		191,410
2016-08-12	2016-08-11	4	Laing Ian Michael	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		144,000		144,000
2016-08-12	2016-08-11	4	Sigal Charles Elliott	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		184,562		184,562
2016-08-12	2016-08-11	4	Knowles Jonathan Kenneth Charles	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		217,222		217,222
2016-05-25	2016-05-24	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		10.4800	518,400	5,433		29,753,404
2016-05-25	2016-05-23	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		10.4000	1,191,600	12,393		29,235,004
2016-05-25	2016-05-20	4	ORBIMED ADVISORS LLC See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		10.0400	2,400	24		28,043,404
2016-05-25	2016-05-24	4	Thompson Peter A. See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		10.4800	518,400	5,433		29,753,404
2016-05-25	2016-05-23	4	Thompson Peter A. See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		10.4000	1,191,600	12,393		29,235,004
2016-05-25	2016-05-20	4	Thompson Peter A. See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		10.0400	2,400	24		28,043,404
2016-05-19	2016-05-19	4	Sigal Charles Elliott Shares held by Sigal Family Investments, LLC	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		1.5600	15,000	23		314,100
2016-05-18	2016-05-18	4	Sigal Charles Elliott Shares held by Sigal Family Investments, LLC	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		1.5500	15,000	23		299,100
2016-05-18	2016-05-17	4	Sigal Charles Elliott Shares held by Sigal Family Investments, LLC	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		1.5300	15,000	23		284,100
2016-05-18	2016-05-16	4	Sigal Charles Elliott Shares held by Sigal Family Investments, LLC	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share	P - Purchase	I		1.5000	15,000	22		269,100
2016-01-20	2016-01-18	4	Rawcliffe Adrian	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		939,948		939,948
2016-01-20	2016-01-18	4	Binder-Scholl Gwendolyn Knowlton	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		704,961		704,961
2016-01-20	2016-01-18	4	TAYTON-MARTIN HELEN KATRINA	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		939,948		939,948
2016-01-20	2016-01-18	4	Noble James	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		1,968,016		1,968,016
2016-01-20	2016-01-18	4	Amado Rafael	ADAP	Option to purchase Ordinary Shares	A - Award	D	1.27		939,948		939,948
2016-01-04		3	Weller Harry R See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	Weller Harry R See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	Sonsini Peter W. See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	Sonsini Peter W. See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	KOLLURI KRISHNA KITTU See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	KOLLURI KRISHNA KITTU See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	Florence Anthony A. Jr. See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	Florence Anthony A. Jr. See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	BARRIS PETER J See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	BARRIS PETER J See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	NEA 14 GP, LTD	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		D						118,538,000
2016-01-04		3	NEA 14 GP, LTD	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		D						118,538,000
2016-01-04		3	NEA 14 GP, LTD	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		D						118,538,000
2016-01-04		3	NEA 14 GP, LTD	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		D						118,538,000
2016-01-04		3	Sigal Charles Elliott Shares held by Sigal Family Investments, LLC	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						561,138
2016-01-04		3	Sigal Charles Elliott Shares held by Sigal Family Investments, LLC	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						561,138
2016-01-04		3	Sigal Charles Elliott	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						359,976
2016-01-04		3	Sigal Charles Elliott	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						359,976
2016-01-04		3	Laing Ian Michael	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						58,085,600
2016-01-04		3	Laing Ian Michael	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						58,085,600
2016-01-04		3	Alleva Lawrence M	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						141,168
2016-01-04		3	Alleva Lawrence M	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						141,168
2016-01-04		3	Knowles Jonathan Kenneth Charles	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						7,208,768
2016-01-04		3	Knowles Jonathan Kenneth Charles	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						14,205,784
2016-01-04		3	Knowles Jonathan Kenneth Charles	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						7,208,768
2016-01-04		3	Knowles Jonathan Kenneth Charles	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						14,205,784
2016-01-04		3	Amado Rafael	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						192,000
2016-01-04		3	Amado Rafael	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						192,000
2016-01-04		3	TAYTON-MARTIN HELEN KATRINA	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						3,630,000
2016-01-04		3	TAYTON-MARTIN HELEN KATRINA	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						3,630,000
2016-01-04		3	Noble James	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						21,145,200
2016-01-04		3	Noble James	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						12,372,600
2016-01-04		3	Noble James	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						21,145,200
2016-01-04		3	Noble James	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		D						12,372,600
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						30,673,708
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						53,449,304
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						30,673,708
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						53,449,304
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						53,449,304
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						30,673,708
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						53,449,304
2016-01-04		3	ISALY SAMUEL D See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						30,673,708
2016-01-04		3	BASKETT FOREST See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	BASKETT FOREST See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	BARRETT M JAMES See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	BARRETT M JAMES See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	MOTT DAVID M See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	MOTT DAVID M See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	KERINS PATRICK J See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	KERINS PATRICK J See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	SANDELL SCOTT D See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	SANDELL SCOTT D See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	Thompson Peter A. See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						53,449,304
2016-01-04		3	Thompson Peter A. See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						30,673,708
2016-01-04		3	Thompson Peter A. See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						53,449,304
2016-01-04		3	Thompson Peter A. See Footnotes	ADAP	Ordinary Shares with a nominal value of GBP0.001 per share		I						30,673,708
2016-01-04		3	Viswanathan Ravi See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000
2016-01-04		3	Viswanathan Ravi See Note 1	ADAP	Ordinary Shares with a nominal value of 0.001 GBP per share		I						118,538,000

Pasaran terbuka atau pembelian persendirian sekuriti bukan derivatif atau derivatif

Pasaran terbuka atau jualan persendirian sekuriti bukan derivatif atau derivatif

Pemberian, penganugerahan atau pemerolehan lain sekuriti daripada syarikat (seperti opsyen)

Penukaran derivatif

Penjualan atau pemindahan sekuriti kembali kepada syarikat

Pembayaran harga pelaksanaan atau liabiliti cukai menggunakan sebahagian daripada sekuriti yang diterima daripada syarikat

Hadiah sekuriti oleh atau kepada orang dalam

Swap ekuiti dan urus niaga lindung nilai yang serupa

Pelaksanaan atau penukaran sekuriti derivatif yang diterima daripada syarikat (seperti opsyen)

Transaksi dilaporkan secara sukarela pada Borang 4

Lain-lain (disertai dengan nota kaki yang menerangkan transaksi)

ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock) - Insider Trading and Ownership Report - SEC Form 3, 4, 5