EIGR / Eiger BioPharmaceuticals, Inc. - Pemfailan SEC, Laporan Tahunan, Penyata Proksi

Eiger BioPharmaceuticals, Inc.
SIMBOL INI TIDAK AKTIF LAGI

Statistik Asas
LEI 549300N6TVZB9N2Q9M78
CIK 1305253
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Eiger BioPharmaceuticals, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan senarai kronologi lengkap bagi Pemfailan SEC, tidak termasuk pemfailan pemilikan yang kami sediakan di tempat lain.
October 1, 2024 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

15-12G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-36183 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as

October 1, 2024 EX-99.1

Case 24-80040-sgj11  Doc 685  Filed 09/30/24  Entered 09/30/24 20:53:07  Desc Main Document  Page 1 of 5 SIDLEY AUSTIN LLP SIDLEY AUSTIN LLP William E. Curtin (admitted pro hac vice) Thomas R. Califano (TX Bar No. 24122825) Anne G. Wallice (admitted

EX-99.1 Exhibit 99.1 Case 24-80040-sgj11  Doc 685  Filed 09/30/24  Entered 09/30/24 20:53:07  Desc Main Document  Page 1 of 5 SIDLEY AUSTIN LLP SIDLEY AUSTIN LLP William E. Curtin (admitted pro hac vice) Thomas R. Califano (TX Bar No. 24122825) Anne G. Wallice (admitted pro hac vice) 2021 McKinney Avenue, Suite 2000 787 Seventh Avenue Dallas, Texas 75201 New York, NY 10019 Telephone: (214) 981-330

October 1, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 30, 2024 EIGER BIOPHARM

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 30, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (

September 9, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 5, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

September 9, 2024 EX-2.1

Case 24-80040-sgj11  Doc 635-1  Filed 09/05/24  Entered 09/05/24 17:02:00  Desc SIDLEY AUSTIN LLP SIDLEY AUSTIN LLP Thomas R. Califano (TX Bar No. 24122825) Charles M. Persons (TX Bar No. 24060413) William E. Curtin (admitted pro hac vice) 2021 McKin

Exhibit 2.1 Case 24-80040-sgj11  Doc 635-1  Filed 09/05/24  Entered 09/05/24 17:02:00  Desc Exhibit A  Page 2 of 58 SIDLEY AUSTIN LLP SIDLEY AUSTIN LLP Thomas R. Califano (TX Bar No. 24122825) Charles M. Persons (TX Bar No. 24060413) William E. Curtin (admitted pro hac vice) 2021 McKinney Avenue, Suite 2000 Anne G. Wallice (admitted pro hac vice) Dallas, Texas 75201 787 Seventh Avenue Telephone: (

September 9, 2024 EX-99.1

Case 24-80040-sgj11  Doc 639  Filed 09/05/24  Entered 09/05/24 18:16:14  Desc Main Document  Page 1 of 66

Exhibit 99.1 Case 24-80040-sgj11  Doc 639  Filed 09/05/24  Entered 09/05/24 18:16:14  Desc Main Document  Page 1 of 66 Docket #0639 Date Filed: 09/05/2024   The following constitutes the ruling of the court and has the force and effect therein described. Signed September 5, 2024 IN THE UNITED STATES BANKRUPTCY COURT FOR THE NORTHERN DISTRICT OF TEXAS DALLAS DIVISION In re: EIGER BIOPHARMACEUTICALS

September 4, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 3, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

September 3, 2024 EX-99.1

Case 24-80040-sgj11  Doc 582  Filed 08/30/24  Entered 08/30/24 15:16:15  Desc Main Document  Page 1 of 12 UNITED STATES BANKRUPTCY COURT Northern DISTRICT OF Texas In Re. Eiger BioPharmaceuticals, Inc. § Case No. 24-80040         §                   

Exhibit 99.1 Case 24-80040-sgj11  Doc 582  Filed 08/30/24  Entered 08/30/24 15:16:15  Desc Main Document  Page 1 of 12 UNITED STATES BANKRUPTCY COURT Northern DISTRICT OF Texas Dallas In Re. Eiger BioPharmaceuticals, Inc. § Case No. 24-80040         §                        § Lead Case No. 24-80040       Debtor(s)     §        ☒ Jointly Administered Monthly Operating Report Chapter 11 Reporting Pe

September 3, 2024 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 30, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

August 26, 2024 SC 13G

EIGR / Eiger BioPharmaceuticals, Inc. / Arkin Moshe - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 Par Value (Title of Class of Securities) 28249U105 (CUSIP Number) August 19, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

August 2, 2024 EX-10.1

LONAFARNIB ASSET PURCHASE AGREEMENT by and between EIGER INNOTHERAPEUTICS, INC., as Purchaser, EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of August 1, 2024

Exhibit 10.1 Execution Version LONAFARNIB ASSET PURCHASE AGREEMENT by and between EIGER INNOTHERAPEUTICS, INC., as Purchaser, and EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of August 1, 2024 Table of Contents ARTICLE 1.  DEFINED TERMS 1 1.1 Defined Terms 1 1.2 Other Definitional and Interpretive Matters 15 ARTICLE 2. THE PURCHASE AND SALE; CLOSING 17 2.1 Purchase and Sale 17 2.2 Excluded A

August 2, 2024 EX-10.2

LAMBDA ASSET PURCHASE AGREEMENT by and between EIGER INNOTHERAPEUTICS, INC., as Purchaser, EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of August 1, 2024

Exhibit 10.2 Execution Version LAMBDA ASSET PURCHASE AGREEMENT by and between EIGER INNOTHERAPEUTICS, INC., as Purchaser, and EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of August 1, 2024 TABLE OF CONTENTS ARTICLE 1.  DEFINED TERMS 1 1.1 Defined Terms 1 1.2 Other Definitional and Interpretive Matters 12 ARTICLE 2.  THE PURCHASE AND SALE; CLOSING 15 2.1 Purchase and Sale 15 2.2 Excluded Asse

August 2, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

August 1, 2024 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

August 1, 2024 EX-99.1

Case 24-80040-sgj11  Doc 480  Filed 07/31/24  Entered 07/31/24 18:53:14  Desc Main Document  Page 1 of 13 UNITED STATES BANKRUPTCY COURT Northern DISTRICT OF Texas In Re. Eiger BioPharmaceuticals, Inc. § Case No. 24-80040         §                   

Exhibit 99.1 Case 24-80040-sgj11  Doc 480  Filed 07/31/24  Entered 07/31/24 18:53:14  Desc Main Document  Page 1 of 13 UNITED STATES BANKRUPTCY COURT Northern DISTRICT OF Texas Dallas In Re. Eiger BioPharmaceuticals, Inc. § Case No. 24-80040         §                        § Lead Case No. 24-80040       Debtor(s)     §        ☒ Jointly Administered Monthly Operating Report Chapter 11 Reporting Pe

July 16, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 15, 2024 EIGER BIOPHARMACEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 15, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

July 16, 2024 EX-99.1

Case 24-80040-sgj11  Doc 424  Filed 07/15/24  Entered 07/15/24 21:34:38  Desc Main Document  Page 1 of 52

EX-99.1 Case 24-80040-sgj11  Doc 424  Filed 07/15/24  Entered 07/15/24 21:34:38  Desc Main Document  Page 1 of 52 Exhibit 99.1 SIDLEY AUSTIN LLP SIDLEY AUSTIN LLP Thomas R. Califano (TX Bar No. 24122825) Charles M. Persons (TX Bar No. 24060413) William E. Curtin (admitted pro hac vice) 2021 McKinney Avenue, Suite 2000 Anne G. Wallice (admitted pro hac vice) Dallas, Texas 75201 787 Seventh Avenue T

July 16, 2024 EX-99.2

Case 24-80040-sgj11  Doc 425  Filed 07/15/24  Entered 07/15/24 22:02:18  Desc Main Document   Page 1 of 80 IN THE UNITED STATES BANKRUPTCY COURT FOR THE NORTHERN DISTRICT OF TEXAS DALLAS DIVISION In re: Chapter 11 EIGER BIOPHARMACEUTICALS INC., et al

EX-99.2 Exhibit 99.2 Case 24-80040-sgj11  Doc 425  Filed 07/15/24  Entered 07/15/24 22:02:18  Desc Main Document   Page 1 of 80 IN THE UNITED STATES BANKRUPTCY COURT FOR THE NORTHERN DISTRICT OF TEXAS DALLAS DIVISION In re: Chapter 11 EIGER BIOPHARMACEUTICALS INC., et al.1 Case No. 24-80040 (SGJ) (Jointly Administered) Debtors. DISCLOSURE STATEMENT FOR JOINT PLAN OF LIQUIDATION OF EIGER BIOPHARMAC

July 10, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 9, 2024 EIGER BIOPHARMACEUTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 9, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commis

July 1, 2024 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 28, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

July 1, 2024 EX-99.1

Case 24-80040-Sgj11   Doc 385-7   Filed 06/28/24   Entered 06/28/24 19:12:34   Desc 7   Page 1 of 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exch

Exhibit 99.1 Case 24-80040-sgj11 Doc 385 Filed 06/28/24 Entered 06/28/24 19:12:34 Desc Main Document Page 1 of 12 UNITED STATES BANKRUPTCY COURT Northern DISTRICT OF Texas Dallas In Re. Eiger BioPharmaceuticals, Inc. § Case No. 24-80040 § § Lead Case No. 24-80040 Debtor(s) § Jointly Administered Monthly Operating Report Chapter 11 Reporting Period Ended: 05/31/2024 Petition Date: 04/01/2024 Months

July 1, 2024 SC 13D/A

EIGR / Eiger BioPharmaceuticals, Inc. / Arkin Moshe - SC 13D/A Activist Investment

SC 13D/A 1 zk2431622.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 Par Value (Title of class of securities) 28249U105 (CUSIP number) Moshe Arkin 6 HaChoshlim St., Bldg. C, Herzliya 46724, Israel Telephone: 972-972-9-78

June 21, 2024 EX-10.1

ASSET PURCHASE AGREEMENT by and between Amylyx Pharmaceuticals, Inc., or a wholly owned subsidiary thereof, as Purchaser, EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of June 21, 2024

Exhibit 10.1 Execution Copy ASSET PURCHASE AGREEMENT by and between Amylyx Pharmaceuticals, Inc., or a wholly owned subsidiary thereof, as Purchaser, and EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of June 21, 2024 Table of Contents Page ARTICLE 1. DEFINED TERMS 1 1.1 Defined Terms 1 1.2 Other Definitional and Interpretive Matters 11 ARTICLE 2. THE PURCHASE AND SALE; CLOSING 13 2.1 Purchase

June 21, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

June 14, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

June 14, 2024 EX-10.1

ASSET PURCHASE AGREEMENT by and between SPRUCE BIOSCIENCES, INC., as Purchaser, EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of June 13, 2024

Exhibit 10.1 Execution Version ASSET PURCHASE AGREEMENT by and between SPRUCE BIOSCIENCES, INC., as Purchaser, and EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of June 13, 2024 Table of Contents Page SCHEDULES Schedule 1.1(a) Permitted Liens Schedule 2.1(a) Transferred Inventory Schedule 2.1(b) Assigned Contracts Schedule 2.11 Preliminary Allocation Schedule Schedule 3.3 Seller Conflict; Req

May 28, 2024 EX-99.1

Case 24-80040-sgj11 Doc 288 Filed 05/24/24 Entered 05/24/24 19:17:29 Desc Main Document Page 1 of 12

Exhibit 99.1 Case 24-80040-sgj11 Doc 288 Filed 05/24/24 Entered 05/24/24 19:17:29 Desc Main Document Page 1 of 12 Docket #0288 Date Filed: 05/24/2024 UNITED STATES BANKRUPTCY COURT   Northern DISTRICT OF Texas                Dallas          In Re. Eiger BioPharmaceuticals, Inc. § Case No. 24-80040         §                        § Lead Case No. 24-80040       Debtor(s)     §        ☒ Jointly Admi

May 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 24, 2024 EIGER BIOPHARMACEUTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 24, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commis

May 10, 2024 SC 13G/A

EIGRQ / Eiger BioPharmaceuticals, Inc. / AMERIPRISE FINANCIAL INC - SC 13G/A Passive Investment

SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Amendment #7 Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U204 (CUSIP Number) April 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Sc

May 10, 2024 EX-99.I

to Schedule 13G

EX-99.I 2 d838097dex99i.htm EX-99.I Exhibit I to Schedule 13G Ameriprise Financial, Inc., a Delaware Corporation, is a parent holding company. The classification and identity of the relevant subsidiaries is as follows: Investment Adviser – Columbia Management Investment Advisers, LLC is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.

May 10, 2024 EX-99.II

to Schedule 13G Joint Filing Agreement

EX-99.II 3 d838097dex99ii.htm EX-99.II Exhibit II to Schedule 13G Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13G dated May 10, 2024 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc. Each of Columbia Seligman Technology and Information Fund and Columbia Management Investment Advisers, LLC author

May 8, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 3, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commiss

May 2, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 26, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

April 29, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ T

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from      to     

April 29, 2024 EX-10.30

Amended 2021 Inducement Plan.

Exhibit 10.30 EIGER BIOPHARMACEUTICALS, INC. AMENDED 2021 INDUCEMENT PLAN 1. PURPOSE OF PLAN The purpose of this Eiger BioPharmaceuticals, Inc. 2021 Inducement Plan (this “Plan”) of Eiger BioPharmaceuticals, Inc., a Delaware corporation (the “Company”), is to advance the interests of the Company by providing a material inducement for the best available individuals to join the Company and its Subsi

April 8, 2024 EX-97.1

Eiger BioPharmaceuticals, Inc. Policy on Recoupment of Incentive Compensation (incorporated by reference to Exhibit 97.1 to the Annual Report on Form 10-K (File No. 001-36183) filed with the SEC on April 8, 2024).

Exhibit 97.1 EIGER BIOPHARMACEUTICALS, INC. POLICY ON RECOUPMENT OF INCENTIVE COMPENSATION Introduction The Board of Directors (the “Board”) of Eiger BioPharmaceuticals, Inc. (the “Company”) has adopted this Policy on Recoupment of Incentive Compensation (this “Policy”), which provides for the recoupment of compensation in certain circumstances in the event of a restatement of financial results by

April 8, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-361

April 3, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 EX-10.1

Asset Purchase Agreement, dated March 31, 2024, by and between Sentynl Therapeutics, Inc. and Eiger BioPharmaceuticals, Inc.*

Exhibit 10.1 EXECUTION VERSION ASSET PURCHASE AGREEMENT by and between SENTYNL THERAPEUTICS, INC., as Purchaser, and EIGER BIOPHARMACEUTICALS, INC., as Seller Dated as of March 31, 2024 Table of Contents Page ARTICLE 1.  DEFINED TERMS 2 1.1 Defined Terms 2 1.2 Other Definitional and Interpretive Matters 12 ARTICLE 2.  THE PURCHASE AND SALE; CLOSING 15 2.1 Purchase and Sale 15 2.2 Excluded Assets 1

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one):  ☒ Form 10-K  ☐ Form 20-F  ☐ Form 11-K  ☐ Form 10-Q ☐ Form 10-D  ☐ Form N-CEN  ☐ Form N-CSR For Period Ended: December 31, 20

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one):  ☒ Form 10-K  ☐ Form 20-F  ☐ Form 11-K  ☐ Form 10-Q ☐ Form 10-D  ☐ Form N-CEN  ☐ Form N-CSR For Period Ended: December 31, 2023 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transit

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 EX-99.1

Eiger BioPharmaceuticals Files for Voluntary Chapter 11 Protection Announces “Stalking Horse” Agreement for the Sale of Zokinvy® (lonafarnib) Patient Access to Zokinvy® to Continue Uninterrupted

Exhibit 99.1 Eiger BioPharmaceuticals Files for Voluntary Chapter 11 Protection Announces “Stalking Horse” Agreement for the Sale of Zokinvy® (lonafarnib) Patient Access to Zokinvy® to Continue Uninterrupted Palo Alto, Calif., April 1, 2024 — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR) today announced that it and its direct subsidiaries have filed voluntary petitions for chapter 11 protection und

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 S-8 POS

As filed with the Securities and Exchange Commission on April 1, 2024

As filed with the Securities and Exchange Commission on April 1, 2024 Registration No.

April 1, 2024 8-K

Bankruptcy or Receivership

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

March 11, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 8, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

February 14, 2024 SC 13G/A

EIGR / Eiger BioPharmaceuticals, Inc. / AMERIPRISE FINANCIAL INC - SC 13G/A Passive Investment

SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Amendment #6 Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

February 14, 2024 EX-99.II

to Schedule 13G Joint Filing Agreement

EX-99.II Exhibit II to Schedule 13G Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13G dated February 14, 2024 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc. Each of Columbia Seligman Technology and Information Fund and Columbia Management Investment Advisers, LLC authorizes Ameriprise Financial

February 14, 2024 EX-99.I

to Schedule 13G

EX-99.I Exhibit I to Schedule 13G Ameriprise Financial, Inc., a Delaware Corporation, is a parent holding company. The classification and identity of the relevant subsidiaries is as follows: Investment Adviser – Columbia Management Investment Advisers, LLC is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.

February 14, 2024 SC 13G/A

EIGR / Eiger BioPharmaceuticals, Inc. / 683 Capital Management, LLC - 683 CAPITAL MANAGEMENT, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common stock, $0.001 par value per share (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to design

January 24, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 18, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

January 8, 2024 EX-3.1

Certificate of Amendment to the Amended and Restated Certificate of Incorporation of Eiger BioPharmaceuticals, Inc. (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K, filed with the SEC on January 8, 2024).

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF EIGER BIOPHARMACEUTICALS, INC. Eiger BioPharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware, hereby certifies as follows: FIRST: The original Certificate of Incorporation of the Corporation was filed

January 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2024 EIGER BIOPHARMACE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2024 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

January 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 28, 2023 EIGER BIOPHARMA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 28, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

January 4, 2024 EX-99.1

Eiger BioPharmaceuticals, Inc. Announces

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals, Inc. Announces 1-for-30 Reverse Stock Split Palo Alto, Calif., January 4, 2024 /PRNewswire/ — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR) (the “Company”), a commercial-stage biopharmaceutical company focused on the development of innovative therapies for rare metabolic diseases, today announced that it will conduct a reverse stock split of its outsta

December 11, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as perm

December 4, 2023 SC 13D/A

EIGR / Eiger BioPharmaceuticals Inc / Arkin Moshe - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 Par Value (Title of class of securities) 28249U105 (CUSIP number) Moshe Arkin 6 HaChoshlim St., Bldg. C, Herzliya 46724, Israel Telephone: 972-972-9-7883330 with a copy to: Goldfarb Gro

December 1, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permi

November 24, 2023 SC 13D

EIGR / Eiger BioPharmaceuticals Inc / Arkin Moshe - SC 13D Activist Investment

SC 13D 1 zk2330592.htm SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 Par Value (Title of class of securities) 28249U105 (CUSIP number) Jim Harding 1900 Avenue of the Stars, #1000 Los Angeles, CA 90067 908-507-9629 Mark Morski 1900 Avenue of th

November 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2023 EIGER BIOPHARMA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

November 9, 2023 EX-10.2

Promotion Letter Agreement, dated as of September 21, 2023, by and between Eiger BioPharmaceuticals, Inc. and Ingrid Choong (incorporated by reference to Exhibit 10.2 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on November 9, 2023).

Exhibit 10.2 CONFIDENTIAL September 21, 2023 Ingrid Choong Senior Vice President, Clinical Development Dear Ingrid, Eiger is very pleased to offer you a promotion to Chief Business Officer reporting directly to David Apelian, Chief Executive Officer. Your new responsibilities are outlined in the attached job description. Your remote position will continue to be headquartered at 2155 Park Blvd, Pal

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 9, 2023 EX-99.1

Press release, dated August 14, 2023, titled "Eiger BioPharmaceuticals Reports Second Quarter 2023 Financial Results and Provides Business Update

Exhibit 99.1 Eiger BioPharmaceuticals Reports Second Quarter 2023 Financial Results and Provides Business Update •Resources prioritized to advance avexitide in hyperinsulinemic hypoglycemia indications •Active discussions underway with potential partners to advance late-stage virology programs •Reduction in workforce executed to align with focus on avexitide; extends cash runway to into Q4 2024 •D

November 9, 2023 EX-10.1

Offer Letter Agreement/Employment Agreement, dated as of November 25, 2019, by and between Eiger BioPharmaceuticals, Inc. and Ingrid Choong (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on November 9, 2023).

Exhibit 10.1 25 November 2019 Eiger BioPharmaceuticals, Inc. 2155 Park Boulevard Palo Alto, CA 94306 Ingrid Choong, Ph.D. Re: Employment Terms Dear Dr. Choong, Eiger BioPharmaceuticals, Inc. (“Eiger” or the “Company”) is pleased to offer the following terms to govern your continued employment in this Letter Agreement (“Agreement”). Duties, Compensation and Benefits You will continue to serve as th

November 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2023 EIGER BIOPHARMAC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

November 9, 2023 EX-99.1

Eiger BioPharmaceuticals Reports Third Quarter 2023 Financial Results and Provides Business Update

Eiger BioPharmaceuticals Reports Third Quarter 2023 Financial Results and Provides Business Update •Resources prioritized to advance avexitide in hyperinsulinemic hypoglycemia indications •Phase 3 LIMT-2 study of peginterferon lambda in chronic hepatitis delta discontinued due to safety findings •Company’s cash runway expected to extend into the third quarter of 2024 Palo Alto, Calif.

November 3, 2023 SC 13D/A

EIGR / Eiger BioPharmaceuticals Inc / Propel Bio Management, LLC - SC 13D/A Activist Investment

SC 13D/A 1 ef20013959sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Eiger Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 282 49U 105 (CUSIP Number) Jim Harding 1900 Avenue of the Stars, #1000 Los Angeles, CA 90067 908-507-96

October 20, 2023 EX-99.1

Exhibit 99.1

EX-99.1 2 ef20012872ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 JOINT FILING AGREEMENT This will confirm the agreement by and among the undersigned that the Schedule 13D filed with the Securities and Exchange Commission on or about the date hereof with respect to the beneficial ownership by the undersigned of the common stock, par value $0.001 per share, of Eiger BioPharmaceuticals, Inc., a Delaware corp

October 20, 2023 SC 13D

EIGR / Eiger BioPharmaceuticals Inc / Propel Bio Management, LLC - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.)* Eiger Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 282 49U 105 (CUSIP Number) Jim Harding 1900 Avenue of the Stars, #1000 Los Angeles, CA 90067 908-507-9629 Mark Morski 1900 Avenue of the Stars, #1

September 28, 2023 SC 13G/A

EIGR / Eiger BioPharmaceuticals Inc / Propel Bio Management, LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* EIGER BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) 9/14/2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

September 12, 2023 EX-99.1

Eiger to Discontinue Phase 3 LIMT-2 Trial of Peginterferon Lambda in Patients with Chronic Hepatitis Delta

EX-99.1 Exhibit 99.1 Eiger to Discontinue Phase 3 LIMT-2 Trial of Peginterferon Lambda in Patients with Chronic Hepatitis Delta Palo Alto, Calif., September 12, 2023 /PRNewswire/ — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), a commercial-stage biopharmaceutical company focused on the development of innovative therapies for rare metabolic diseases, today announced its decision to discontinue the

September 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2023 EIGER BIOPHARM

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (

August 15, 2023 SC 13G

EIGR / Eiger BioPharmaceuticals Inc / Propel Bio Management, LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* EIGER BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) 8/02/2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this S

August 14, 2023 EX-99.1

Eiger BioPharmaceuticals Reports Second Quarter 2023 Financial Results and Provides Business Update

Eiger BioPharmaceuticals Reports Second Quarter 2023 Financial Results and Provides Business Update •Resources prioritized to advance avexitide in hyperinsulinemic hypoglycemia indications •Active discussions underway with potential partners to advance late-stage virology programs •Reduction in workforce executed to align with focus on avexitide; extends cash runway to into Q4 2024 •David Apelian, MD, PhD, MBA, appointed CEO Palo Alto, Calif.

August 14, 2023 EX-10.2

Offer Letter Agreement, dated as of March 31, 2023, by and between Eiger BioPharmaceuticals, Inc. and James Vollins (incorporated by reference to Exhibit 10.2 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on August 14, 2023).

Exhibit 10.2 March 31, 2023 Jim Vollins Dear Jim, On behalf of Eiger BioPharmaceuticals, Inc. (the “Company”), I am pleased to confirm the terms and conditions of your offer of at-will employment, with an anticipated start date, Monday April 10, 2023 (“Start Date”), pursuant to this letter (this “Letter”). Assuming you satisfy the contingencies below, this Letter sets forth the terms and condition

August 14, 2023 EX-10.3

Consulting Agreement, dated as of March 10, 2023, by and between Eiger BioPharmaceuticals, Inc. and Danforth Advisors, LLC (incorporated by reference to Exhibit 10.3 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on August 14, 2023).

Exhibit 10.3 CONSULTING AGREEMENT This Consulting Agreement (the “Agreement”) is made effective as of March 10, 2023 (the “Effective Date”), by and between Eiger BioPharmaceuticals, Inc., a Delaware corporation, with a business address at 2155 Park Boulevard, Palo Alto, CA 94306 (the “Company”) and Danforth Advisors, LLC, a Massachusetts limited liability company, with its principal place of busin

August 14, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

August 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

July 28, 2023 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

June 30, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 28, 2023 EIGER BIOPHARMACEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 28, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

June 30, 2023 EX-10.1

Amended and Restated Employment Terms, by and between Eiger BioPharmaceuticals, Inc. and David Apelian, dated as of June 28, 2023 (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K (File No. 001-36183) filed with the SEC on June 30, 2023).

EX-10.1 Exhibit 10.1 June 28, 2023 VIA ELECTRONIC MAIL David Apelian, MD, PhD, MBA Re: Amended and Restated Employment Terms Dear Dr. Apelian, You and Eiger BioPharmaceuticals, Inc. (“Eiger” or the “Company”) wish to enter into this Amended and Restated Employment Terms (“Agreement”), embodying the terms of your new role with the Company, and to replace in its entirety and supersede the terms of t

June 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2023 EIGER BIOPHARMACEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

May 11, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

May 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2023 EIGER BIOPHARMACEUTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commis

May 11, 2023 EX-99.1

Eiger BioPharmaceuticals Reports First Quarter 2023 Financial Results and Provides Business Update

Eiger BioPharmaceuticals Reports First Quarter 2023 Financial Results and Provides Business Update •Phase 3 HDV D-LIVR (lonafarnib/ritonavir) Study: Pre-NDA Meeting with FDA in Q2 2023 •Phase 3 HDV LIMT-2 (peginterferon lambda) Study: Complete Randomization in Q2 2023 •Phase 3 HI AVANT (avexitide) Program: Startup Activities Initiated •Cash Position: $75.

April 26, 2023 DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 26, 2023 DEF 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 18, 2023 SC 13G/A

EIGR / Eiger BioPharmaceuticals Inc / Arkin Moshe - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 Par Value (Title of Class of Securities) 28249U105 (CUSIP Number) April 10, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rul

April 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 12, 2023 EIGER BIOPHARMACEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 12, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

April 10, 2023 EX-99.II

to Schedule 13G Joint Filing Agreement

EX-99.II Exhibit II to Schedule 13G Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13G dated April 10, 2023 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc. Each of Columbia Seligman Technology and Information Fund, Seligman Tech Spectrum (Master) Fund and Columbia Management Investment Advisers,

April 10, 2023 EX-99.I

to Schedule 13G

EX-99.I Exhibit I to Schedule 13G Ameriprise Financial, Inc., a Delaware Corporation, is a parent holding company. The classification and identity of the relevant subsidiaries is as follows: Investment Adviser – Columbia Management Investment Advisers, LLC is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.

April 10, 2023 SC 13G/A

EIGR / Eiger BioPharmaceuticals Inc / AMERIPRISE FINANCIAL INC - SC 13G/A Passive Investment

SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Amendment #5 Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) February 28, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

March 17, 2023 10-K

Form 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-361

March 17, 2023 S-8

As filed with the Securities and Exchange Commission on March 17, 2023

S-8 As filed with the Securities and Exchange Commission on March 17, 2023 Registration No.

March 17, 2023 EX-10.41

ase, dated as of February 6, 2023, by and between Eiger BioPharmaceuticals, Inc. and David A. Cory (incorporated by reference to Exhibit 10.41 to the Annual Report on Form 10-K (File No. 001-36183) filed with the SEC on March 17, 2023).

Exhibit 10.41 SEPARATION AGREEMENT AND GENERAL RELEASE This Separation Agreement and General Release (“Agreement”) is being entered into on the date listed on the signature page hereof by and between David Cory (“Executive”) and Eiger BioPharmaceuticals, Inc. (“Company”). Executive and the Company are referred to jointly as the “Parties” or individually as a “Party.” WHEREAS, Executive was employe

March 17, 2023 EX-10.42

Offer Letter Agreement, dated as January 9, 2023, by and between Eiger BioPharmaceuticals, Inc. and David Apelian (incorporated by reference to Exhibit 10.42 to the Annual Report on Form 10-K (File No. 001-36183) filed with the SEC on March 17, 2023).

Exhibit 10.42 January 9, 2023 VIA ELECTRONIC MAIL ([email protected]) David Apelian, MD, PhD, MBA 3 Old Beach Glen Road Boonton, New Jersey 07005 Re: Interim CEO Employment Terms Dear Dr. Apelian, Eiger BioPharmaceuticals, Inc. (“Eiger” or the “Company”) is pleased to offer employment to you on the following terms of this Offer Letter Agreement (“Agreement”): Duties You will be employed as th

March 17, 2023 EX-10.43

2023, by and between Eiger BioPharmaceuticals, Inc. and the McDonald Family Co. LLC.

Exhibit 10.43 Second Amendment to Lease This Second Amendment to Lease (“Amendment”) is made and entered January 23, 2023 (the “Amendment Effective Date”) by and between McDonald Family Co. LLC (“Lessor”) and Eiger Pharmaceuticals, Inc. (“Lessee”). WHEREAS, Lessor and Lessee are parties to that certain Standard Multi-Tenant Office Lease – Net dated October 17, 2017, as amended with Addendum to Lea

March 17, 2023 EX-FILING FEES

Calculation of Filing Fee Table

EX-FILING FEES EXHIBIT 107 Calculation of Filing Fee Table FORM S-8 (Form Type) Eiger BioPharmaceuticals, Inc.

March 17, 2023 EX-99.3

Eiger BioPharmaceuticals, Inc. Amended and Restated 2021 Inducement Plan.

EX-99.3 Exhibit 99.3 EIGER BIOPHARMACEUTICALS, INC. AMENDED AND RESTATED 2021 INDUCEMENT PLAN Approved by the Board of Directors: June 15, 2021 Amended by the Board of Directors: February 24, 2023 1. PURPOSE OF PLAN The purpose of this Eiger BioPharmaceuticals, Inc. 2021 Inducement Plan (this “Plan”) of Eiger BioPharmaceuticals, Inc., a Delaware corporation (the “Company”), is to advance the inter

March 16, 2023 EX-99.1

Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Business Update

Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Business Update •Phase 3 HDV D-LIVR (lonafarnib/ritonavir) Study: Pre-NDA Meeting Planned by End of Q2 •Phase 3 HDV LIMT-2 (peginterferon lambda) Study: On Track to Complete Randomization by End of Q2 •Phase 3 HI AVANT (avexitide) Program: Startup Activities Initiated •Cash Position: $98.

March 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 EIGER BIOPHARMACEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

March 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 EIGER BIOPHARMACEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

February 14, 2023 SC 13G/A

EIGR / Eiger Biopharmaceuticals Inc / 683 Capital Management, LLC - AMENDMENT NO. 5 TO THE SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (RULE 13d - 102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(b) (Amendment No. 5)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common stock, $0.001 par value per share (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2022

February 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2023 EIGER BIOPHARMAC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

February 9, 2023 SC 13G/A

EIGR / Eiger Biopharmaceuticals Inc / ADAGE CAPITAL PARTNERS GP, L.L.C. - EIGER BIOPHARMACEUTICALS, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule

February 2, 2023 SC 13G/A

EIGR / Eiger Biopharmaceuticals Inc / Arkin Moshe - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 Par Value (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

January 10, 2023 EX-99.I

to Schedule 13G

EX-99.I 2 d407273dex99i.htm EX-99.I Exhibit I to Schedule 13G Ameriprise Financial, Inc., a Delaware Corporation, is a parent holding company. The classification and identity of the relevant subsidiaries is as follows: Investment Adviser – Columbia Management Investment Advisers, LLC is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.

January 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 EIGER BIOPHARMACE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

January 10, 2023 SC 13G/A

EIGR / Eiger Biopharmaceuticals Inc / AMERIPRISE FINANCIAL INC - SC 13G/A Passive Investment

SC 13G/A 1 d407273dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Amendment #4 Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) December 31,2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate th

January 10, 2023 EX-99.II

to Schedule 13G Joint Filing Agreement

EX-99.II 3 d407273dex99ii.htm EX-99.II Exhibit II to Schedule 13G Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13G dated January 10,2023 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc.. Each of Columbia Seligman Technology and Information Fund and Columbia Management Investment Advisers, LLC au

January 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 3, 2023 EIGER BIOPHARMACE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 3, 2023 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

December 20, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 14, 2022 EIGER BIOPHARMA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 14, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

December 8, 2022 EX-99.1

Eiger Announces Both Lonafarnib-based Treatments in Pivotal Phase 3 D-LIVR Trial in Hepatitis Delta Virus (HDV) Achieved Statistical Significance Against Placebo in Composite Primary Endpoint

EX-99.1 Exhibit 99.1 Eiger Announces Both Lonafarnib-based Treatments in Pivotal Phase 3 D-LIVR Trial in Hepatitis Delta Virus (HDV) Achieved Statistical Significance Against Placebo in Composite Primary Endpoint • Lonafarnib/ritonavir response rate of 10.1% (p=0.0044) • Lonafarnib/ritonavir in combination with peginterferon alfa response rate of 19.2% (p<0.0001) • Peginterferon alfa comparator ar

December 8, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 8, 2022 EIGER BIOPHARMAC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 8, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

November 3, 2022 EX-99.1

Eiger BioPharmaceuticals Reports Third Quarter 2022 Financial Results and Provides Business Update

Exhibit 99.1 Eiger BioPharmaceuticals Reports Third Quarter 2022 Financial Results and Provides Business Update ? Phase 3 HDV D-LIVR (lonafarnib-based regimens) Study Topline Data in December ? Phase 3 HDV LIMT-2 (peginterferon lambda) Study Activating Sites and Enrolling Patients ? Phase 3 Congenital Hyperinsulinism Avant (avexitide) Program Initiated ? Strong Cash Position: $121.0 Million in Cas

November 3, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 3, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2022 EIGER BIOPHARMAC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

August 4, 2022 EX-99.1

Eiger BioPharmaceuticals Reports Second Quarter 2022 Financial Results and Provides Business Update

Exhibit 99.1 Eiger BioPharmaceuticals Reports Second Quarter 2022 Financial Results and Provides Business Update ? Active Dialogue with FDA on Potential Peginterferon Lambda COVID-19 EUA Application ? Phase 3 HDV D-LIVR (lonafarnib) Study Topline Data Planned by Year End ? Phase 3 Congenital Hyperinsulinism AVANT (avexitide) Program Initiated ? Approval of Zokinvy in Europe; Partnership with AnGes

August 4, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

August 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

July 18, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 14, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

June 21, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

June 7, 2022 EX-10.1

Loan and Security Agreement, dated June 1, 2022, among Eiger BioPharmaceuticals, Inc., its domestic subsidiaries and Innovatus Life Sciences Lending Fund I, LP, as collateral agent and lender (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed with the SEC on June 7, 2022).

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (as the same may be amended, restated, modified, or supplemented from time to time, this ?Agreement?) dated as of June

June 7, 2022 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commis

June 7, 2022 EX-10.2

Common Stock Purchase Agreement, dated June 1, 2022, among Eiger BioPharmaceuticals, Inc., Innovatus Life Sciences Lending Fund I, LP, Innovatus Life Sciences Offshore Fund I-A, LP, Innovatus Flagship Fund I, LP, and Innovatus Flagship Offshore Fund I, LP (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed with the SEC on June 7, 2022).

Exhibit 10.2 EIGER BIOPHARMACEUTICALS, INC. COMMON STOCK PURCHASE AGREEMENT THIS COMMON STOCK PURCHASE AGREEMENT (the ?Agreement?) is made as of June 1, 2022 (the ?Execution Date?) by and among Eiger BioPharmaceuticals, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each an ?Investor,? and collectively the ?Investors?). RECITALS WHEREAS,

May 11, 2022 SC 13G/A

EIGR / Eiger Biopharmaceuticals Inc / AMERIPRISE FINANCIAL INC - SC 13G/A Passive Investment

SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Amendment #3 Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) (Date of Event Which Requires Filing of this Statement) May 6, 2022 Check the appropriate box to designate the rule pursuant to which this Sched

May 11, 2022 EX-99.I

to Schedule 13G

Exhibit I to Schedule 13G Ameriprise Financial, Inc., a Delaware Corporation, is a parent holding company. The classification and identity of the relevant subsidiaries is as follows: Investment Adviser ? Columbia Management Investment Advisers, LLC is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.

May 11, 2022 EX-99.II

to Schedule 13G Joint Filing Agreement

Exhibit II to Schedule 13G Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13G dated May 11, 2022 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc.

May 5, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commiss

May 5, 2022 EX-99.1

Eiger BioPharmaceuticals Reports First Quarter 2022 Financial Results and Provides Business Update

Exhibit 99.1 Eiger BioPharmaceuticals Reports First Quarter 2022 Financial Results and Provides Business Update • Peginterferon lambda COVID-19 EUA Application to be Submitted in Q2 2022 • Phase 3 HDV D-LIVR (lonafarnib) Study Topline Data Anticipated by Year End • Zokinvy® (lonafarnib) CHMP Opinion Expected in Q2 2022 • Phase 3 Avexitide Congenital Hyperinsulinism Program Initiation Planned by Ye

May 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36183 Eiger Bio

May 2, 2022 SC 13G

EIGR / Eiger Biopharmaceuticals Inc / ADAGE CAPITAL PARTNERS GP, L.L.C. - EIGER BIOPHARMACEUTICALS, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 28249U105 (CUSIP Number) April 21, 2022 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursu

April 28, 2022 DEF 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 28, 2022 DEFA14A

United States Securities and Exchange Commission Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

United States Securities and Exchange Commission Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (a

March 25, 2022 EX-1.1

Open Market Sale AgreementSM, dated March 25, 2022, by and between Eiger BioPharmaceuticals, Inc. and Jefferies LLC

EX-1.1 2 d315548dex11.htm EX-1.1 Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM March 25, 2022 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Eiger BioPharmaceuticals, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “A

March 25, 2022 424B5

$50,000,000 Common Stock

424B5 1 d319148d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-251497 Prospectus Supplement (To Prospectus dated December 31, 2020) $50,000,000 Common Stock We have entered into an Open Market Sale AgreementSM, or the sales agreement, with Jefferies LLC, or Jefferies, relating to the sale of shares of our common stock offered by this prospectus supplement a

March 25, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 25, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

March 17, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 17, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

March 17, 2022 EX-99.1

Eiger’s Single-dose Peginterferon Lambda for COVID-19 Reduced Risk of Hospitalization or ER Visits by 50% in a Predominantly Vaccinated Population in Phase 3 TOGETHER Study

Exhibit 99.1 Eiger?s Single-dose Peginterferon Lambda for COVID-19 Reduced Risk of Hospitalization or ER Visits by 50% in a Predominantly Vaccinated Population in Phase 3 TOGETHER Study ? Second largest study to date in COVID-19 outpatients (N=1,936) ? Highly superior compared to placebo, with a probability of superiority of 99.91% on the primary endpoint ? 60% reduced risk of COVID-19-related dea

March 10, 2022 S-8

As filed with the Securities and Exchange Commission on March 10, 2022

As filed with the Securities and Exchange Commission on March 10, 2022 Registration No.

March 10, 2022 EX-10.38

Amendment No. 4 to Loan and Security Agreement, dated March 10, 2020, by and between Eiger BioPharmaceuticals, Inc. and Oxford Finance LLC.

Exhibit 10.38 DEFAULT WAIVER AND FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS DEFAULT WAIVER AND FOURTH AMENDMENT to Loan and Security Agreement (this ?Amendment?) is entered into as of March 10, 2020, by and between OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria, Virginia 22314 (?Oxford?), as collateral agent (in suc

March 10, 2022 EX-99.1

Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2021 Financial Results and Provides Business Update

Exhibit 99.1 Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2021 Financial Results and Provides Business Update ? Phase 3 COVID-19 TOGETHER (Lambda) Study Data in March 2022 ? Phase 3 HDV D-LIVR (Lonafarnib) Study Topline Data Planned by End of 2022 ? Phase 3 HDV LIMT-2 (Lambda) Study Enrolling ? Strong Cash Position of Approximately $106 Million as of 12/31/21 ? Company to Host Con

March 10, 2022 EX-21.1

List of Subsidiaries.

Exhibit 21.1 Subsidiaries of Registrant Name of Subsidiary Jurisdiction of Incorporation EBPI Merger, Inc. Delaware EB Pharma LLC Delaware Eiger BioPharmaceuticals Europe Limited England and Wales EigerBio Europe Limited Ireland

March 10, 2022 EX-FILING FEES

Calculation of Filing Fee Table

EXHIBIT 107 Calculation of Filing Fee Table FORM S-8 (Form Type) Eiger BioPharmaceuticals, Inc.

March 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

March 10, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-36183 Eiger BioPharma

March 8, 2022 SC 13G

EIGR / Eiger Biopharmaceuticals Inc / Arkin Moshe - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 Par Value (Title of Class of Securities) 28249U105 (CUSIP Number) March 1, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pu

February 14, 2022 SC 13G/A

EIGR / Eiger Biopharmaceuticals Inc / 683 Capital Management, LLC - AMENDMENT NO. 4 TO THE SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (RULE 13d - 102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(b) (Amendment No. 4)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common stock, $0.001 par value per share (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2021

February 11, 2022 SC 13D/A

EIGR / Eiger Biopharmaceuticals Inc / Vivo Ventures VI, LLC - AMENDMENT NO. 5 TO SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 28249U105 (CUSIP Number) Frank Kung Vivo Capital LLC 192 Lytton Avenue Palo Alto, CA 94301 Telephone: (650) 688-0818 (Name, Address

January 21, 2022 EX-99.I

to Schedule 13D Joint Filing Agreement

Exhibit I to Schedule 13D Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13D dated January 21, 2022 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc.

January 21, 2022 SC 13D

EIGR / Eiger Biopharmaceuticals Inc / AMERIPRISE FINANCIAL INC - SC 13D Activist Investment

SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) Columbia Management Investment Advisers Attn: Matthew Rich 290 Congress Street Boston, MA 02210 Tel: (617) 385-9572 (Name, Address and Telephone Numb

January 6, 2022 EX-99.1

Eiger BioPharmaceuticals Announces Outlook and Planned 2022 Catalysts and Milestones

Exhibit 99.1 Eiger BioPharmaceuticals Announces Outlook and Planned 2022 Catalysts and Milestones ? Phase 3 HDV D-LIVR (Lonafarnib) Study Topline Data Planned by End of 2022 ? Phase 3 HDV LIMT-2 (Peginterferon Lambda) Study Enrolling and Dosing ? Phase 3 COVID-19 TOGETHER (Peginterferon Lambda) Study Topline Data 1H22 ? Zokinvy MAA CHMP Opinion Expected 1H22 ? Strong Cash Position of Approximately

January 6, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 6, 2022 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

December 21, 2021 EX-99.1

Eiger BioPharmaceuticals Announces First Patient Enrolled in LIMT-2: A Phase 3 Study of Peginterferon Lambda in Patients with Chronic Hepatitis Delta Virus (HDV) Infection

Exhibit 99.1 Eiger BioPharmaceuticals Announces First Patient Enrolled in LIMT-2: A Phase 3 Study of Peginterferon Lambda in Patients with Chronic Hepatitis Delta Virus (HDV) Infection Palo Alto, Calif., December 21, 2021 / PRNewswire / ? Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), a commercial-stage biopharmaceutical company focused on the development of innovative therapies to treat and cure H

December 21, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 21, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

November 4, 2021 EX-10.2

Amendment No. 6 to Loan and Security Agreement, dated October 6, 2021, by and between Eiger BioPharmaceuticals, Inc. and Oxford Finance LLC (incorporated by reference to Exhibit 10.2 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on November 4, 2021).

Exhibit 10.2 SIXTH AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS SIXTH AMENDMENT to Loan and Security Agreement (this ?Amendment?) is entered into as of October 6, 2021, by and between OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, Virginia 22314 (?Oxford?), as collateral agent (in such capacity, ?Collateral Agent?)

November 4, 2021 EX-99.1

Eiger BioPharmaceuticals Reports Third Quarter 2021 Financial Results and Provides Business Update - Phase 3 HDV D-LIVR (Lonafarnib) Enrolled; Topline Data Planned by End of 2022 - Phase 3 HDV LIMT-2 (Peginterferon Lambda) Enrolling - Company to Host

Exhibit 99.1 Eiger BioPharmaceuticals Reports Third Quarter 2021 Financial Results and Provides Business Update - Phase 3 HDV D-LIVR (Lonafarnib) Enrolled; Topline Data Planned by End of 2022 - Phase 3 HDV LIMT-2 (Peginterferon Lambda) Enrolling - Company to Host Conference Call Today at 4:30 PM ET Palo Alto, Calif., November 4, 2021 /PRNewswire/ ? Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), a c

November 4, 2021 EX-10.1

Offer Letter Agreement, by and between Eiger BioPharmaceuticals, Inc. and Erik Atkisson, dated as of August 26, 2021 (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on November 4, 2021).

Exhibit 10.1 August 26, 2021 Erik Atkisson 1648 Versailles Avenue Alameda, California 94501 Re:Employment Terms Dear Mr. Atkisson, Eiger BioPharmaceuticals, Inc. (?Eiger? or the ?Company?) is pleased to offer you employment on the following terms of this Offer Letter Agreement (?Agreement?). Duties, Compensation and Benefits You will serve as the General Counsel, Corporate Secretary, and Chief Com

November 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36183 Eiger

November 4, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

September 10, 2021 EX-99.II

to Schedule 13G Joint Filing Agreement

Exhibit II to Schedule 13G Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13G dated September 10, 2021 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc.

September 10, 2021 EX-99.I

to Schedule 13G

Exhibit I to Schedule 13G Ameriprise Financial, Inc., a Delaware Corporation, is a parent holding company. The classification and identity of the relevant subsidiaries is as follows: Investment Adviser ? Columbia Management Investment Advisers, LLC is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.

September 10, 2021 SC 13G/A

EIGR / Eiger Biopharmaceuticals Inc / AMERIPRISE FINANCIAL INC - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Amendment #2 Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) August 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule i

August 6, 2021 SC 13D/A

EIGR / Eiger Biopharmaceuticals Inc / Vivo Ventures VI, LLC - AMENDMENT NO. 5 TO SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 28249U105 (CUSIP Number) Frank Kung Vivo Capital LLC 192 Lytton Avenue Palo Alto, CA 94301 Telephone: (650) 688-0818 (Name, Address

August 5, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36183 Eiger BioP

August 5, 2021 EX-10.1

2021 Inducement Plan (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on August 5, 2021).

Exhibit 10.1 EIGER BIOPHARMACEUTICALS, INC. 2021 INDUCEMENT PLAN 1. PURPOSE OF PLAN The purpose of this Eiger BioPharmaceuticals, Inc. 2021 Inducement Plan (this ?Plan?) of Eiger BioPharmaceuticals, Inc., a Delaware corporation (the ?Company?), is to advance the interests of the Company by providing a material inducement for the best available individuals to join the Company and its Subsidiaries a

August 5, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 5, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

August 5, 2021 EX-99.1

Eiger BioPharmaceuticals Inc. Condensed Consolidated Balance Sheets (in thousands) June 30, December 31, 2021 2020(1) (unaudited) ASSETS Cash and cash equivalents $ 65,056 $ 28,864 Short-term debt securities 42,311 99,976 Accounts receivable 1,438 —

EX-99.1 2 d209255dex991.htm EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Reports Second Quarter 2021 Financial Results and Provides Business Update • HDV Platform Strategy Rapidly Advancing • Phase 3 HDV D-LIVR (Lonafarnib) >90% Enrolled; On-Track for Full Enrollment in 2021 • Phase 3 HDV LIMT-2 (Lambda) On-Track for First Patient to Enroll in 2021 • All Five Rare Disease Programs Now Have Breakt

August 5, 2021 S-8

As filed with the Securities and Exchange Commission on August 5, 2021.

As filed with the Securities and Exchange Commission on August 5, 2021. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 EIGER BIOPHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) Delaware 33-0971591 (State or other jurisdiction of incorporation or organization)

June 15, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

May 6, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commiss

May 6, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36183 Eiger Bio

May 6, 2021 EX-10.2

Form of Restricted Stock Unit Award Grant Notice and Award Agreement under 2013 Equity Incentive Plan (incorporated by reference to Exhibit 10.2 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on May 6, 2021).

Exhibit 10.2 Eiger BioPharmaceuticals, Inc. Restricted Stock Unit Award Grant Notice 2013 Equity Incentive Plan Eiger BioPharmaceuticals, Inc. (the ?Company?) hereby awards to Participant the number of Restricted Stock Units specified and on the terms set forth below (the ?Award?). The Award is subject to all of the terms and conditions as set forth in this Restricted Stock Unit Award Grant Notice

May 6, 2021 EX-99.1

Eiger BioPharmaceuticals Inc. Condensed Consolidated Balance Sheets (in thousands) Three Months Ended March 31 Year Ended December 31, 2021 2020(1) (unaudited) ASSETS Cash and cash equivalents $ 108,410 $ 28,864 Debt securities, available-for-sale 52

Exhibit 99.1 Eiger BioPharmaceuticals Reports First Quarter 2021 Financial Results and Provides Business Update ? Phase 3 HDV D-LIVR (Lonafarnib) 75% Enrolled; Full Enrollment Planned in 2021 ? Phase 3 HDV LIMT-2 (Lambda) to Initiate in 2021 ? Phase 3 COVID-19 TOGETHER Platform Study to Include Lambda Arm ? $3.6M U.S. Zokinvy? Net Sales in Q1 2021 Palo Alto, Calif., May 6, 2021 /PRNewswire/ ? Eige

April 29, 2021 DEFA14A

- DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 28, 2021 DEF 14A

Schedule 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 22, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 21, 2021 Eiger BioPharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Comm

April 9, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

March 9, 2021 EX-21.1

List of subsidiaries.

Exhibit 21.1 Subsidiaries of Registrant Name of Subsidiary Jurisdiction of Incorporation EBPI Merger, Inc. Delaware EB Pharma LLC Delaware Eiger BioPharmaceuticals Europe Limited England and Wales EigerBio Europe Limited Ireland

March 9, 2021 EX-10.31

Asset Purchase Agreement, by and between Eiger BioPharmaceuticals, Inc. and AbbVie Inc., dated as of November 20, 2020 (incorporated by reference to Exhibit 10.31 to the Annual Report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

Exhibit 10.31 Execution Version ASSET PURCHASE AGREEMENT BY AND BETWEEN ABBVIE INC. AND EIGER BIOPHARMACEUTICALS, INC. NOVEMBER 20, 2020 Table of Contents Page Table ARTICLE 1 DEFINITIONS 1 1.1 Certain Definitions 1 ARTICLE 2 PURCHASE AND SALE; CLOSING 5 2.1 Purchase and Sale of Purchased Assets. 5 2.2 Purchase Price 6 2.3 Closing 6 2.4 Title Passage; Delivery of Purchased Assets. 6 2.5 Closing De

March 9, 2021 EX-10.32

Amendment No. 7 to License Agreement, dated November 3, 2020, by and between Eiger BioPharmaceuticals, Inc. and Merck Sharp & Dohme Corp (incorporated by reference to Exhibit 10.32 to the Annual Report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

Exhibit 10.32 AMENDMENT #7 TO LICENSE AGREEMENT This Amendment #7 to License Agreement (?Amendment #7?) is entered into as of the date of last signature below (?Amendment #7 Effective Date?) by and between Merck Sharp & Dohme Corp. (formerly known as Schering Corporation), a New Jersey corporation having a place of business at 2000 Galloping Hill Road, Kenilworth, NJ 07033 (?Merck?) and Eiger BioP

March 9, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 9, 2021. Registration No. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 EIGER BIOPHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) Delaware 2834 33-0971591 (State or other jurisdiction of incorporation or organization) (

March 9, 2021 EX-10.10

License Agreement, dated September 3, 2010, by and between Eiger BioPharmaceuticals, Inc. and Merck Corporation (incorporated by reference to Exhibit 10.10 to the Annual report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

March 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

March 9, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-36183 Eiger BioPharma

March 9, 2021 EX-10.18

Collaboration and Supply Agreement, dated May 15, 2018, by and between Eiger BioPharmaceuticals, Inc. and The Progeria Research Foundation (incorporated by reference to Exhibit 10.18 to the Annual report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

March 9, 2021 EX-10.12

License Agreement, dated as of April 20, 2016, by and between Eiger BioPharmaceuticals, Inc. and Bristol-Myers Squibb Company (incorporated by reference to Exhibit 10.12 to the Annual report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

March 9, 2021 EX-10.17

Amendment No. 6 to License Agreement, dated September 3, 2010, by and between Eiger BioPharmaceuticals, Inc. and Merck Sharp & Dohme Corp (incorporated by reference to Exhibit 10.17 to the Annual report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

March 9, 2021 EX-10.9

Asset Purchase Agreement, dated September 25, 2015, by and between Eiger BioPharmaceuticals, Inc. and Tracey McLaughlin and Colleen Craig (incorporated by reference to Exhibit 10.9 to the Annual report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

March 9, 2021 EX-99.1

Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2020 Financial Results and Provides Business Update

Exhibit 99.1 Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2020 Financial Results and Provides Business Update ? Phase 3 HDV D-LIVR (Lonafarnib) to Complete Enrollment in 2021 ? Phase 3 HDV LIMT-2 (Lambda) to Initiate in 2021 ? Strong Cash Position with $176 Million Pro-Forma Cash to Begin 2021 Palo Alto, Calif., March 9, 2021 /PRNewswire/ ? Eiger BioPharmaceuticals, Inc. (Nasdaq:E

March 9, 2021 EX-10.33

Amendment No. 5 to Loan and Security Agreement, dated February 23, 2021, by and between Eiger BioPharmaceuticals, Inc. and Oxford Finance LLC (incorporated by reference to Exhibit 10.33 to the Annual Report on Form 10-K (File No. 001-36183) filed with the SEC on March 9, 2021).

Exhibit 10.33 FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS FIFTH AMENDMENT to Loan and Security Agreement (this ?Amendment?) is entered into as of February [], 2021, by and between OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, Virginia 22314 (?Oxford?), as collateral agent (in such capacity, ?Collateral Agen

February 16, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (RULE 13d - 102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(b) (Amendment No. 3)* Eiger BioPha

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (RULE 13d - 102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(b) (Amendment No. 3)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common stock, $0.001 par value (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2020 (Date of

February 12, 2021 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Cla

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 28249U105 (CUSIP Number) Frank Kung Vivo Capital LLC 192 Lytton Avenue Palo Alto, CA 94301 Telephone: (650) 688-0818 (Name, Address

February 11, 2021 SC 13G/A

Eiger Biopharmaceuticals, Inc.

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Eiger Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule

January 11, 2021 EX-99.II

Joint Filing Agreement

EX-99.II Exhibit II to Schedule 13G Joint Filing Agreement The undersigned persons agree and consent to the joint filing on their behalf of this Schedule 13G dated January 11, 2021 in connection with their beneficial ownership of Eiger BioPharmaceuticals, Inc. Columbia Management Investment Advisers, LLC authorizes Ameriprise Financial, Inc. to execute the Schedule 13G to which this Exhibit is att

January 11, 2021 SC 13G

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December 31, 2020 (Date of

SC 13G SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities and Exchange Act of 1934 Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is fi

January 11, 2021 EX-99.I

Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company.

EX-99.I Exhibit I to Schedule 13G Ameriprise Financial, Inc., a Delaware Corporation, is a parent holding company. The classification and identity of the relevant subsidiaries is as follows: Investment Adviser – Columbia Management Investment Advisers, LLC is an investment adviser registered under section 203 of the Investment Advisers Act of 1940.

January 7, 2021 8-K

Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 7, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

January 7, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 7, 2021 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

January 7, 2021 EX-99.1

Eiger BioPharmaceuticals Updates on 2020 Progress and 2021 Plans

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Updates on 2020 Progress and 2021 Plans • Phase 3 HDV D-LIVR (Lonafarnib) Planned to Complete Enrollment in 2021 • Phase 3 HDV LIMT-2 (Lambda) Planned to Initiate in 2H21 • Zokinvy™ EMA Approval Expected in 2H21 • Strong Cash Position with ~$176M Pro Forma Cash to Begin 2021 Palo Alto, Calif., January 7, 2021 /PRNewswire/ — Eiger BioPharmaceuticals, In

January 4, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

December 28, 2020 CORRESP

-

CORRESP EIGER BIOPHARMACEUTICALS, INC. 2155 Park Boulevard Palo Alto, CA 94306 (877) 899-2051 December 28, 2020 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Deanna Virginio Re: Eiger BioPharmaceuticals, Inc. Registration Statement on Form S-3 Filed December 18, 2020 File No. 333-25

December 18, 2020 EX-4.5

Form of Common Stock Warrant Agreement and Warrant Certificate.

EX-4.5 4 d73885dex45.htm EX-4.5 Exhibit 4.5 EIGER BIOPHARMACEUTICALS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF EIGER BIOPHARMACEUTICALS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between EIGER BIOPHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [na

December 18, 2020 EX-4.3

Form of Debt Indenture.

EX-4.3 3 d73885dex43.htm EX-4.3 Exhibit 4.3 EIGER BIOPHARMACEUTICALS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20 Debt Securities TABLE OF CONTENTS PAGE ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Sec

December 18, 2020 EX-4.7

Form of Debt Securities Warrant Agreement and Warrant Certificate.

Exhibit 4.7 EIGER BIOPHARMACEUTICALS, INC. AND , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF EIGER BIOPHARMACEUTICALS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [•], between EIGER BIOPHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking associat

December 18, 2020 EX-4.6

Form of Preferred Stock Warrant Agreement and Warrant Certificate.

EX-4.6 5 d73885dex46.htm EX-4.6 Exhibit 4.6 EIGER BIOPHARMACEUTICALS, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF EIGER BIOPHARMACEUTICALS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between EIGER BIOPHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and [•], a [corpora

December 18, 2020 EX-1.2

Open Market Sale AgreementSM, dated December 18, 2020, between the Company and Jefferies LLC.

Exhibit 1.2 OPEN MARKET SALE AGREEMENTSM December 18, 2020 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Eiger BioPharmaceuticals, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’

December 18, 2020 S-3

- S-3

S-3 Table of Contents As filed with the Securities and Exchange Commission on December 18, 2020 Registration No.

November 23, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Other Events - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 20, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

November 23, 2020 EX-99.1

Eiger BioPharmaceuticals Sells Priority Review Voucher for $95 Million

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Sells Priority Review Voucher for $95 Million • Eiger and The Progeria Research Foundation will share proceeds 50/50 • Non-dilutive capital further strengthens Eiger’s balance sheet PALO ALTO, Calif., November 23, 2020 / PRNewswire / — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), focused on the development and commercialization of targeted therapies f

November 5, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36183 Eiger

November 5, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

November 5, 2020 EX-99.1

Eiger BioPharmaceuticals Inc. Condensed Consolidated Balance Sheets (in thousands) Nine Months Ended Year Ended September 30, December 31, 2020 2019(1) (unaudited) ASSETS Cash and cash equivalents $ 51,993 $ 39,373 Debt securities, available-for-sale

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Reports Third Quarter 2020 Financial Results and Provides Business Update Palo Alto, Calif., November 5, 2020 /PRNewswire/ — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), focused on the development and commercialization of targeted therapies for serious rare and ultra-rare diseases, today reported financial results for third quarter 2020 and provided a

October 15, 2020 8-K

Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 15, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

August 6, 2020 424B5

Common Stock

Prospectus Supplement Filed Pursuant to Rule 424(b)(5) Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No.

August 6, 2020 EX-99.1

Eiger BioPharmaceuticals Inc. Condensed Consolidated Balance Sheets (in thousands) Six Months Ended June 30, Year Ended December 31, 2020 2019(1) (unaudited) ASSETS Cash and cash equivalents $ 62,813 $ 39,373 Debt securities, available-for-sale 27,96

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Reports Second Quarter 2020 Financial Results and Provides Business Update PALO ALTO, Calif., August 6, 2020 /PRNewswire/ — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), focused on the development and commercialization of targeted therapies for serious rare and ultra-rare diseases, today reported financial results for second quarter 2020 and provided a

August 6, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporati

August 6, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36183 Eiger BioP

August 6, 2020 EX-1.1

Open Market Sale AgreementSM, dated August 6, 2020, between Eiger BioPharmaceuticals, Inc. and Jefferies LLC.

Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM August 6, 2020 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Eiger BioPharmaceuticals, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s c

August 6, 2020 EX-10.1

Amendment No. 1, dated June 15, 2020, to the Collaboration and Supply Agreement, dated May 15, 2018, by and between Eiger BioPharmaceuticals, Inc. and the Progeria Research Foundation (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on August 6, 2020).

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM IF PUBLICLY DISCLOSED.

June 17, 2020 8-K

Submission of Matters to a Vote of Security Holders

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (C

May 29, 2020 DEFA14A

- DEFA14A

DEFA14A United States Securities and Exchange Commission Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

May 19, 2020 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 19, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Co

May 19, 2020 EX-99.1

Eiger BioPharmaceuticals Announces FDA Acceptance of NDA for Filing with Priority Review of Zokinvy

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Announces FDA Acceptance of NDA for Filing with Priority Review of Zokinvy™ (lonafarnib) for Treatment of Progeria and Progeroid Laminopathies PALO ALTO, Calif. May 19, 2020 — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), focused on the development and commercialization of targeted therapies for serious rare and ultra-rare diseases, today announced tha

May 7, 2020 EX-99.1

Eiger BioPharmaceuticals Inc. Condensed Consolidated Balance Sheets (in thousands) Three Months Ended March 31, Year Ended December 31, 2020 2019(1) (unaudited) ASSETS Cash and cash equivalents $ 22,629 $ 39,373 Debt securities, available-for-sale 54

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Reports First Quarter 2020 Financial Results and Provides Business Update PALO ALTO, Calif., May 7, 2020 — Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), focused on the development and commercialization of targeted therapies for serious rare and ultra-rare diseases, today reported financial results for first quarter 2020 and provided a business update.

May 7, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Com

May 7, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-36183 Eiger Bio

May 7, 2020 EX-10.2

Eiger BioPharmaceuticals, Inc. Non-Employee Director Compensation Policy, as amended (incorporated by reference to Exhibit 10.2 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on May 7, 2020).

Exhibit 10.2 Eiger Biopharmaceuticals, Inc. Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) who is not also serving as an employee of Eiger BioPharmaceuticals, Inc. (“Eiger”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compensation Policy for his or her Boar

May 7, 2020 EX-10.1

Offer Letter Agreement, by and between Eiger BioPharmaceuticals, Inc. and Eldon Mayer, dated as of December 3, 2019 (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-36183) filed with the SEC on May 7, 2020).

Exhibit 10.1 December 3, 2019 Eiger BioPharmaceuticals, Inc. 2155 Park Boulevard Palo Alto, CA 94306 Mr. Eldon Mayer 15657 Shady Lane Los Gatos, California 95032 Re:Employment Terms Dear Mr. Mayer, Eiger BioPharmaceuticals, Inc. (“Eiger” or the “Company”) is pleased to offer you employment on the following terms of this Offer Letter Agreement (“Agreement”). Duties, Compensation and Benefits You wi

April 28, 2020 DEF 14A

Schedule 14A

DEF 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 28, 2020 DEFA14A

- DEFA14A

DEFA14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 1, 2020 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (Commi

April 1, 2020 EX-99.1

Eiger BioPharmaceuticals Provides Update on Clinical Development Activities and Business Operations During COVID-19 Pandemic

Exhibit 99.1 Eiger BioPharmaceuticals Provides Update on Clinical Development Activities and Business Operations During COVID-19 Pandemic - HDV Phase 3 D-LIVR Study Progressing; Impact to Timeline - Peginterferon Lambda Investigator-Sponsored Studies in COVID-19 Initiating PALO ALTO, Calif. April 1, 2020 - Eiger BioPharmaceuticals, Inc. (Nasdaq:EIGR), focused on the development and commercializati

March 23, 2020 8-K

Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 23, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (

March 13, 2020 EX-99.1

Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2019 Financial Results and Provides Business Update

EX-99.1 Exhibit 99.1 Eiger BioPharmaceuticals Reports Fourth Quarter and Full Year 2019 Financial Results and Provides Business Update - Progeria MAA Submission Completed and Accelerated Assessment Granted by EMA - Progeria NDA Submission Complete by End of March 2020 - Phase 3 HDV Global D-LIVR Study Enrolling and Dosing PALO ALTO, Calif., March 13, 2020 — Eiger BioPharmaceuticals, Inc. (Nasdaq:E

March 13, 2020 EX-21.1

List of subsidiaries.

Exhibit 21.1 Subsidiaries of Registrant Name of Subsidiary Jurisdiction of Incorporation EBPI Merger, Inc. Delaware EB Pharma LLC Delaware Eiger BioPharmaceuticals Europe Limited England and Wales EigerBio Europe Limited Ireland

March 13, 2020 10-K

EIGR / Eiger BioPharmaceuticals, Inc. 10-K - Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-36183 Eiger BioPharma

March 13, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2020 EIGER BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36183 33-0971591 (State or other jurisdiction of incorporation) (

March 13, 2020 EX-4.3

Description of Registrant’s Securities (incorporated by reference to Exhibit 4.3 to the Annual Report on Form 10-K (File No. 001-36183), filed with the SEC on March 13, 2020).

Exhibit 4.3 DESCRIPTION OF CAPITAL STOCK DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 Eiger BioPharmaceuticals, Inc. (“we,” “our,” or “us,”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): our common stock, $0.001 par value per share (the “common s

March 13, 2020 S-8

EIGR / Eiger BioPharmaceuticals, Inc. S-8 - - FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on March 13, 2020. Registration No. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 EIGER BIOPHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) Delaware 2834 33-0971591 (State or other jurisdiction of incorporation or organ

February 14, 2020 SC 13G/A

EIGR / Eiger BioPharmaceuticals, Inc. / EcoR1 Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2) Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designa

February 14, 2020 SC 13G/A

EIGR / Eiger BioPharmaceuticals, Inc. / RA Capital Management, LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Eiger BioPharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 28249U105 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to design

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